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Composition capable of regulating immunity and improving intestinal flora and preparation method thereof

A technology for intestinal flora and immune regulation, applied in the field of biomedicine, can solve problems such as unclear drug efficacy, unclear mechanism of action, toxic side effects or potential safety hazards, etc., to improve immunity, improve body immunity, improve The effect of gut microbiota structure

Inactive Publication Date: 2022-02-15
WEST ANHUI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many types of traditional Chinese medicine immunostimulants reported at present, most of them are rarely used in practical applications due to unclear efficacy, unclear mechanism of action, toxic side effects or potential safety hazards, which are far from meeting the needs of the current situation. The need for immune boosters

Method used

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  • Composition capable of regulating immunity and improving intestinal flora and preparation method thereof
  • Composition capable of regulating immunity and improving intestinal flora and preparation method thereof
  • Composition capable of regulating immunity and improving intestinal flora and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] This embodiment provides a kind of composition prepared by Polygonatum, the preparation method of said composition is as follows:

[0035] Accurately weigh 1.0 kg of freshly dried Rhizoma Polygonatum, crush it to 40-100 mesh, put it in a round-bottomed flask, add 75% ethanol according to the ratio of solid to liquid 1:8, heat and reflux for extraction twice, each time for 2 hours, and extract Filtrate, combine the filtrates, concentrate under reduced pressure at 45°C until there is no alcohol smell, and obtain the extract of Rhizoma Polygonatum. In this example, 1200 mL of Polygonatum extract was obtained. After measurement, its thermal density was 1.14 g / mL, and the crude drug concentration was approximately 0.83 g / mL.

[0036]Separation and purification of Rhizoma Polygonatum: after pretreatment with AB-8 weakly polar macroporous adsorption resin, the column was packed, and 650mL of the above-mentioned Rhizoma Rhizoma Polygonatum extract was taken on the column at a f...

Embodiment 2

[0046] This embodiment provides a kind of Polygonatum mixed tablet prepared by Rhizoma Polygonatum, which comprises Polygonatum mixed component, carrageenan, ascorbic acid, resistant starch, magnesium stearate, and talcum powder. The preparation method is as follows:

[0047] Accurately weigh 1.0 kg of freshly dried Rhizoma Polygonatum medicinal material, crush it to 40-100 mesh and place it in a round-bottomed flask, add 75% ethanol according to the ratio of solid to liquid at 1:12, heat and reflux for extraction for 4 hours to obtain the extract and filter it, at 40 Under the condition of ℃, it was concentrated under reduced pressure until there was no alcohol smell, and the extract of Rhizoma Polygonatum was obtained. After pretreatment with D101 weakly polar macroporous adsorption resin, load the column, take 650mL of Rhizoma Rhizoma Polygonatum extract and put it on the column at a flow rate of 3BV / h, first elute with 7 to 8 times the column volume of water, discard solut...

Embodiment 3

[0050] This embodiment provides a kind of Polygonatum mixed tablet prepared by Polygonatum, the Polygonatum mixed tablet comprises Polygonatum PSE30, carrageenan, ascorbic acid, resistant starch, magnesium stearate, talcum powder The preparation method is as follows:

[0051] Accurately weigh 1.0kg of freshly dried Polygonatum medicinal material, crush it to 40-100 mesh and place it in a round-bottomed flask, add 75% ethanol according to the ratio of solid to liquid at 1:10, heat and reflux for extraction for 4 hours to obtain the extract and filter it at 40 Under the condition of ℃, it was concentrated under reduced pressure until there was no alcohol smell, and the extract of Rhizoma Polygonatum was obtained. After pretreatment with ADS21 weak polarity macroporous adsorption resin, the column was packed, and 650mL of Polygonatum extract was taken on the column at a flow rate of 5BV / h, followed by water, 30%, 75% and 95% ethanol for elution, and collected The 30% ethanol elua...

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Abstract

The invention discloses a composition with immune regulation and intestinal flora improvement effects and a preparation method thereof, and belongs to the technical field of biomedicines. The composition comprises rhizoma polygonati PSE30 and rhizoma polygonati PSE75, and the rhizoma polygonati PSE30 and the rhizoma polygonati PSE75 are obtained by sequentially purifying an alcohol extract of rhizoma polygonati through macroporous resin and then adding water for suspension. Experiments show that the polygonatum sibiricum PSE30 and the polygonatum sibiricum PSE75 provided by the invention have a remarkable effect of improving the immunity of the organism, can regulate the intestinal flora structure and can be used for preparing immunoregulation medicines and health-care products, and compared with the prior art, the components of the polygonatum sibiricum for effectively improving the intestinal flora structure and the components of the polygonatum sibiricum for improving the immunity are separated for the first time, and is of great significance to research and development of rhizoma polygonati medicinal preparations with clinical application value.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to a composition capable of regulating immunity and improving intestinal flora and a preparation method thereof. Background technique [0002] Polygonatum, as a widely used medicinal and edible homologous plant, was first recorded in "Shen Nong's Materia Medica". The effect of nourishing the kidney". It has shown potential medicinal value in anti-aging, regulating body immunity, regulating blood fat, blood sugar, improving memory, anti-tumor, and antibacterial. In recent years, sealwort has been used more and more in aspects such as nutrition and health care, and prevention of senile diseases, which has greatly promoted the development of sealwort industry. Since Rhizoma Polygonatum is a plant of the same origin as medicine and food, the industry entry threshold is low, resulting in products with low technical content, small scale, and scattered to thousands of hous...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61P37/04A61P1/00A23L33/105
CPCA61K36/8969A61P37/04A61P1/00A23L33/105A61K2236/333A61K2236/39A61K2236/53A61K2236/51A61K2236/55A23V2002/00A23V2200/324A23V2200/32A23V2250/21
Inventor 何燕飞孙传伯陈存武蒋平徐光沛
Owner WEST ANHUI UNIV
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