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Porous rhodium nano-material as well as preparation method and anti-tumor application thereof

A nanomaterial and porous structure technology, applied in the field of nanobiomaterials, can solve the problem of anti-tumor application of porous rhodium nanomaterials, and achieve excellent photothermal treatment effect, enhancement effect, and the effect of reducing tissue damage.

Active Publication Date: 2022-02-08
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, although porous rhodium nanomaterials have been reported, they are only used as nanocatalysts, and there are no applications of porous rhodium nanomaterials in anti-tumor aspects such as photothermal therapy and glutathione depletion.

Method used

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  • Porous rhodium nano-material as well as preparation method and anti-tumor application thereof
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  • Porous rhodium nano-material as well as preparation method and anti-tumor application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Step 1. Weigh 100mg sodium hexachlororhodium and add it to 10mL deionized water, fully dissolve to obtain solution I; weigh 120mg sodium ascorbate and add it to 10mL deionized water, fully dissolve to obtain solution II; weigh 30mg ethylene oxide -b-Add polymethyl methacrylate to 6mL N,N-dimethylformamide, fully dissolve it, then gradually add it dropwise to 4mL deionized water, and stir at 500rpm to obtain solution III.

[0032] Step 2. Add solution I dropwise to solution III gradually, while stirring at 500rpm; stop stirring after dropping, and let it stand at room temperature for 20 minutes, quickly add solution II to the mixed solution, shake it evenly, and place it at 60°C After reacting for 10 hours in a water bath, take it out to cool and centrifuge to obtain a solid precipitate.

[0033] Step 3. Wash and centrifuge the solid precipitate obtained in step 2 (after washing and centrifuging three times with N,N-dimethylformamide, and then washing and centrifuging th...

Embodiment 2

[0036] Step 1. Weigh 150mg sodium hexachlororhodium and add it to 10mL deionized water, fully dissolve to obtain solution I; weigh 180mg sodium ascorbate and add it to 10mL deionized water, fully dissolve to obtain solution II; weigh 50mg ethylene oxide -b-Add polymethyl methacrylate to 6mL N,N-dimethylformamide, fully dissolve it, then gradually add it dropwise to 4mL deionized water, and stir at 600rpm to obtain solution III.

[0037] Step 2. Add solution Ⅰ dropwise to solution Ⅲ gradually, while maintaining stirring at 800rpm; stop stirring after dropping, and let it stand at room temperature for 20 minutes, quickly add solution Ⅱ to the mixed solution, shake it evenly and place it at 60°C After reacting for 12 hours in a water bath, take it out for cooling and centrifugation to obtain a solid precipitate.

[0038] Step 3. Wash and centrifuge the solid precipitate obtained in step 2 (after washing and centrifuging three times with N,N-dimethylformamide, and then washing and...

Embodiment 3

[0041] Step 1. Weigh 200mg sodium hexachlororhodium and add it to 10mL deionized water, fully dissolve to obtain solution I; weigh 240mg sodium ascorbate and add it to 10mL deionized water, fully dissolve to obtain solution II; weigh 70mg ethylene oxide -b-Add polymethyl methacrylate to 6mL N,N-dimethylformamide, fully dissolve it, then gradually add it dropwise to 4mL deionized water, and stir at 600rpm to obtain solution III.

[0042] Step 2. Add solution Ⅰ to solution Ⅲ step by step, while stirring at 1000rpm; stop stirring after dropping, and let it stand at room temperature for 20 minutes, quickly add solution Ⅱ to the mixed solution, shake it evenly and place it at 60°C After reacting for 14 hours in a water bath, take it out for cooling and centrifugation to obtain a solid precipitate.

[0043] Step 3. Wash and centrifuge the solid precipitate obtained in step 2 (after washing and centrifuging three times with N,N-dimethylformamide, and then washing and centrifuging thr...

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Abstract

The invention discloses a porous rhodium nano-material as well as a preparation method and anti-tumor application thereof. The particle size of the porous rhodium nano-material is 20-200nm, and the pore diameter is 5-20nm. The porous rhodium nano material has excellent photo-thermal conversion performance, can improve the photo-thermal treatment targeting tumor effect, reduce the damage of illumination to tissues, enhance the photo-thermal tumor cell killing effect and improve the photo-thermal treatment effect, and breaks the oxidation-reduction balance in tumor cells by depleting glutathione, so that the tumor cells are killed; the preparation method disclosed by the invention is simple and feasible, is easy to amplify and is used for commercial production, and opens up a new way for popularizing the application of the biological nano material.

Description

technical field [0001] The invention relates to a porous rhodium nanomaterial, a preparation method thereof and an anti-tumor application, belonging to the technical field of nanobiological materials. Background technique [0002] Cancer has been a difficult problem that has plagued mankind for many years. Due to the lack of effective treatment methods, the number of deaths from cancer is increasing year by year. Traditional treatment often adopts surgery, radiotherapy, chemotherapy or their combination, but there are certain limitations. Therefore, new treatments are needed to improve the efficacy of cancer treatment and prolong the survival of patients. Photothermal therapy uses the photothermal conversion effect of photothermal reagents to convert absorbed light energy into thermal energy, thereby generating local hyperthermia to destroy tumor cells. Since the near-infrared light used in the treatment has strong tissue penetration ability and does not cause body damage,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61P35/00B22F1/054B22F1/07B22F9/24B82Y5/00B82Y20/00B82Y40/00
CPCA61K41/0052A61P35/00B82Y5/00B82Y20/00B82Y40/00B22F9/24
Inventor 余跃王海香缪昭华
Owner UNIV OF SCI & TECH OF CHINA
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