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Hydrogen sulphide compounds capable of stimulating h2s production in a pregnant subject

A pre-eclampsia, growth-restricted technology, applied in the field of H2S-generating compounds, which can solve problems such as unclear effects

Pending Publication Date: 2022-02-08
MIRZYME THERAPEUTICS LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

9 Obviously, H 2 S has multiple roles in health and disease, 10,11 However, its role in pregnancy-induced hypertension is unclear

Method used

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  • Hydrogen sulphide compounds capable of stimulating h2s production in a pregnant subject
  • Hydrogen sulphide compounds capable of stimulating h2s production in a pregnant subject
  • Hydrogen sulphide compounds capable of stimulating h2s production in a pregnant subject

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0034] Materials and methods

[0035] Placental Tissue Collection and Preparation

[0036] Institutional ethics committees approved blood and tissue collection and written informed consent was obtained. We analyzed blood samples from women with singleton pregnancies collected from low-risk and high-risk outpatient and labor and delivery departments. All women were followed as expected from registration until delivery. Human placental tissue was collected from preeclampsia and uncomplicated pregnancies delivered by elective cesarean section. Placental tissue samples were processed for RNA extraction and maternal plasma from the same patients was collected for analysis (n=14 PE and n=14 controls). Placenta were harvested from another group of patients for immunohistochemical studies (n=5 PE and n=5 controls). Preeclampsia was defined as at least 2 consecutive measurements of blood pressure greater than 140 / 90 mmHg and maternal proteinuria of at least 300 mg / 24 hours. First ...

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PUM

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Abstract

The present application relates to the use of a H2S-producing compound for the treatment of preeclampsia or fetal growth limitation, wherein the H2S-producing compound is ACS 14, ACS 83, ACS 84, ACS 85, ACS 86, diallyl trisulfide, S-diclofenac, GSH hydropersulfate, SG1002, ADT-OH, TBZ, thioglycine, 1-thiolysine, 1-thiovaline or a salt thereof, H2S-latanoprost, H2S-sildenafil or H2S-L-dopa.

Description

[0001] The application date is March 3, 2014 and the title of the invention is "capable of stimulating H in pregnant individuals 2 Hydrogen sulfide compound produced by S” is a divisional application of Chinese invention patent application 201480024804.3. technical field [0002] The present invention relates to the generation of H 2 Use of a compound of S for the treatment of pre-eclampsia or fetal growth restriction in a pregnant individual. Background technique [0003] The gas signal molecule hydrogen sulfide (H 2 S) promote vasodilation 1 and stimulate angiogenesis in the vasculature 2 . h 2 S has anti-inflammatory properties 3 , and has a cytoprotective effect on cell damage caused by lethal hypoxia or reperfusion injury. 4,5 Cystathionine γ-lyase (CSE) is responsible for H 2 The main enzyme for the endogenous production of S. 6 Long-term administration of the CSE inhibitor DL-propargylglycine (PAG) leads to increased blood pressure and vascular remodeling in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/616A61K31/10A61K31/196A61K31/105A61K31/385A61K31/198A61K33/04A61K31/5575A61K31/519A61P9/12A61P15/00A61P43/00
CPCA61K31/095A61K31/675A61P15/00A61P15/06A61P19/00A61P21/00A61P43/00A61P9/12
Inventor A·艾哈迈德K·王
Owner MIRZYME THERAPEUTICS LTD
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