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Biomarker for predicting tumor drug sensitivity and related product thereof

A biomarker and sensitivity technology, applied in the field of biomedicine, can solve difficult-to-predict problems and achieve high accuracy and good clinical application prospects

Inactive Publication Date: 2022-01-28
QINGDAO MEDINTELL BIOMEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the immune drug MAGE-A3 therapy is widely used in the adjuvant treatment of clinical melanoma, but it is still difficult to predict which melanoma patients will be sensitive and / or responsive to the immune drug MAGE-A3 therapy. The sensitivity or responsiveness of patients to the immune drug MAGE-A3 remains a great challenge, therefore, the discovery of biologics that can be used to accurately predict the sensitivity and / or responsiveness of melanoma patients to the immune drug MAGE-A3 treatment regimen Biomarkers and their application in pre-treatment screening of melanoma patients is critical to the field and can help individualize treatment

Method used

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  • Biomarker for predicting tumor drug sensitivity and related product thereof
  • Biomarker for predicting tumor drug sensitivity and related product thereof
  • Biomarker for predicting tumor drug sensitivity and related product thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Example 1 Screening of genes related to the sensitivity of metastatic melanoma to immune drug MAGE-A3

[0068] 1. Data sources and screening methods

[0069] Patients with clinically diagnosed metastatic melanoma were collected, and none of these patients had received immunotherapy with MAGE-A3 before immunotherapy with MAGE-A3. Before the patients with metastatic melanoma collected above received the immune drug MAGE-A3 immunotherapy, the tumor biopsy tissues of the patients were collected, and the response group (R, responder) or non-response group ( Differentially expressed genes in tumor tissues of NR, non-responder) patients. The MAGE-A3 immunotherapy refers to administering the immune drug MAGE-A3 to patients with metastatic melanoma, and the immune drug MAGE-A3 refers to a substance obtained by dissolving recombinant MAGE-A3 protein in an immunostimulator (AS02B or AS15) . Among them, according to whether the metastatic melanoma is responsive / sensitive to the ...

Embodiment 2

[0073] Application of Differentially Expressed Genes Screened in Example 2 in Predicting Sensitivity of Melanoma to Immunotherapy Drug MAGE-A3

[0074] 1. Experimental method

[0075] For the genes differentially expressed between the responder group and the non-response group screened in Example 1, receiver operating characteristic (ROC) analysis was performed using the R package "pROC" (version 1.15.0), and the receiver operating characteristic (ROC) was calculated. The area under the characteristic curve (AUC) is used to evaluate the accuracy of a single differentially expressed gene, any combination of two differentially expressed genes, and the combination of three differentially expressed genes for predicting the sensitivity of melanoma to the immune drug MAGE-A3 treatment, wherein the The range of AUC value is 0-1;

[0076] Among them, when judging the diagnostic efficacy of a single differentially expressed gene for predicting the sensitivity of melanoma to the immuno...

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Abstract

The invention discloses a biomarker for predicting tumor drug sensitivity and a related product thereof, wherein the biomarker is HLA-F, CLHC1 and / or ELFN1, and the product comprises a reagent for detecting the expression level of the biomarker. The biomarker and the related product thereof are used for predicting the sensitivity of metastatic melanoma patients to an immunotherapy drug MAGE-A3, clinical medication is guided by using the biomarker and the related product thereof provided by the technical scheme of the invention, not only can the blindness of drug selection be avoided, but also the treatment effect of the drug can be monitored in the treatment process, and the purposes of medication reasonability and individualized treatment are achieved.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, in particular, the invention relates to a biomarker for predicting tumor drug sensitivity and related products. Background technique [0002] Melanoma (Melanoma) is a highly malignant tumor derived from melanocytes in the basal layer of the epidermis. skin cancer. In recent years, the morbidity and mortality of melanoma in the world have shown a significant increase trend, accounting for 1%-3% of all malignant tumors, but the growth rate is 6%-7% year by year, and the age of onset is younger It is one of the fastest growing malignant tumors. There are obvious racial differences in the incidence of melanoma, with the highest incidence in whites and lower incidence in yellows and blacks. The main cause of death in melanoma patients is the tumor's susceptibility to rapid metastasis. Melanoma has the characteristics of high malignancy, rapid progression, and early metastasis. Moreover, in rec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886G01N33/574G16C20/30
CPCC12Q1/6886G01N33/5743G01N33/57484G01N33/57488G16C20/30C12Q2600/106C12Q2600/158G01N2800/52G01N2800/60
Inventor 杨承刚郭静范冰燕王丹李雨晨
Owner QINGDAO MEDINTELL BIOMEDICAL CO LTD
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