Pharmaceutical composition for preventing and treating anaplasma disease of sheep in pasturing area and preparation method thereof

A technology for aplasmosis and a composition is applied in the field of pharmaceutical compositions for preventing and treating sheep aplasmosis in pastoral areas and the field of preparation thereof, which can solve the problems of unsatisfactory effect of supplementary feeding of sick sheep, and achieve the improvement of immune function of the body and the improvement of palatability. and improve the effect of bone marrow microcirculation

Active Publication Date: 2022-01-28
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Most of the existing nutritional and mineral licking brick products increase the content of nutrients in the licking brick, supplement and increase animal nutrition intake by adding conventional feed materials, trace elements and minerals, but for blood infection without plasma, The effect of supplementary feeding on sick sheep with elevated body temperature, decreased physical fitness, and low stress response is not ideal

Method used

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  • Pharmaceutical composition for preventing and treating anaplasma disease of sheep in pasturing area and preparation method thereof
  • Pharmaceutical composition for preventing and treating anaplasma disease of sheep in pasturing area and preparation method thereof
  • Pharmaceutical composition for preventing and treating anaplasma disease of sheep in pasturing area and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: Preparation of licking bricks for preventing and treating sheep anaerobic disease in pastoral areas

[0034] Materials: Whole ration compound feed for cattle and sheep (Baofa Agriculture and Animal Husbandry, net content 40kg / bag, purchased from Guyuan Baofa Agriculture and Animal Husbandry Co., Ltd.). Radix Changshan extract (with a 5% ketone content), Caoguo extract (a 10:1 purity specification) and Polygonum multiflorum extract (a 10:1 purity specification), were purchased from Shaanxi Xintianyu Biotechnology Co., Ltd.; Artemisia extract (purity 98%) was purchased from Hunan Oasis Plant Resources Development Co., Ltd.; Angelica sinensis extract (food grade, 10:1 extract) was purchased from Shaanxi Panier Biotechnology Co., Ltd. Oxytetracycline (≧98%, CAS79-57-2), purchased from Shanghai Macklin Biochemical Technology Co., Ltd. Mannan oligosaccharides (food grade, purity 99%, product number 15516382283) were purchased from Zhengzhou Best Food Additive Co.,...

Embodiment 2

[0104] Embodiment 2: This embodiment also evaluates the efficacy of brick licking in vivo

[0105] In order to further illustrate the essence of the present invention, the applicant has carried out following test to the licking brick of the present application.

[0106] The licking bricks used in the experiment are made by the Lanzhou Institute of Animal Husbandry and Veterinary Medicine, Chinese Academy of Agricultural Sciences. They contain Chinese medicine extracts, trace elements and minerals, basic feed and drug additives. The specification of licking bricks is a cube of 16cm in length x 16cm in width x 16cm in height, with a middle hole diameter of 3.0cm and a weight of about 6.0kg / block.

[0107] Experimental location and sheep flock: select grazing sheep from Huangcheng Sheep Farm, Sunan Yugur Autonomous County, Zhangye City, Gansu Province.

[0108] Inclusion criteria for infection-positive sheep:

[0109] Before the test, the epidemiological investigation of the sh...

Embodiment 3

[0139] Example 3: In vitro efficacy evaluation of traditional Chinese medicine composition contained in brick licking

[0140] In view of the Chinese medicine extract Changshan extract and Artemisia annua extract added in the present invention, it is the traditional medicine for antimalarial and deworming, heat-clearing and antipyretic and cooling blood to stop bleeding in my country, and Changshan extract wherein also has anti-amoeba and leptin The role of spirochetes. Therefore, in this in vitro pharmacological test, the optimal number of extracts of Changshan extract, Artemisia annua extract and the combination of the two were selected to conduct in vitro plasma-free killing test research.

[0141] 1. Collection of plasma-free blood: Use a sterile syringe to collect 10 mL of fresh blood (from the jugular vein) of a sheep suspected of being infected. There is aplasma in red blood cells, the size is about 0.3 ~ 1 μm, mostly located at the edge of the cell, it is a dense, roun...

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Abstract

The invention discloses a lick brick for preventing and treating an anaplasma disease of sheep in a pasturing area. The lick brick is characterized by comprising the following raw materials: full-ration compound feed for cattle and sheep, a traditional Chinese medicine extract composition, oxytetracycline, mannan oligosaccharide, a trace element and mineral composition, a phagostimulant composition, vinasse residue powder and molasses, wherein the traditional Chinese medicine extract composition comprises antifebrile dichroa root extract, sweet wormwood herb extract, amomum tsao-ko extract, angelica sinensis extract and polygonum multiflorum extract, the trace element and mineral composition comprises sodium selenite, shell powder, sea salt, medical stone powder and calcium bentonite, and the phagostimulant composition comprises kelp powder, chilli powder and black sesame powder. The lick brick has the effects of replenishing and nourishing blood and recovering the blood circulation system function of sick animals on the basis of the drug effects of expelling parasites, resisting diseases and treating the anaplasma disease of sheep; and energy can be supplemented for sick sheep, the appetite and digestion and absorption functions of the sheep are effectively enhanced, growth is promoted, immunity and anti-stress capacity are improved, sick animals are guaranteed to recover as early as possible and keep a healthy physiological state, and the lick brick has the advantages of being easy and convenient to use and the like.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a pharmaceutical composition for preventing and treating sheep anplasma disease in pastoral areas and a preparation method thereof. Background technique [0002] Anplasmosis is a chronic and acute infectious disease of ruminants caused by anplasma, characterized by high fever, anemia, emaciation, jaundice, and gallbladder enlargement. The clinical features of the disease are fever, anemia, jaundice and emaciation. Worldwide distribution. The mortality rate of sheep and goats reaches 17%. There are three kinds of aplasma that are pathogenic to cattle and sheep: anaplasma marginalis subspecies marginal, aplasma marginalis central subspecies and ovine anplasmaeum. Aplasma has almost no cytoplasm, its size is about 0.3-1 micron, mostly located at the edge of the cell, it is a dense, round or oval inclusion body, Gram staining is negative, Giemsa staining is purple, mai...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K50/10
CPCA23K50/10A23K10/30A23K20/30A23K10/26A23K20/28A23K20/105A23K20/163A23K10/38A23K10/33A23K20/20A23K40/20A61K36/185A61K36/282A61K36/9064A61K36/232A61K36/704A61P1/14A61P1/16A61P29/00A61P7/06A61K2300/00Y02P60/87
Inventor 王玲郭文柱郭志廷崔东安柏建明蔡应生沙赫巴兹杨峰魏小娟王春梅张小甫郝宝成杨珍吕嘉文程峰
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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