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Preparation method and application of porous alginate membrane

A technology of alginate and sodium alginate, which is applied in the field of preparation of porous alginate membranes, can solve the problems of unsuitable large-scale processing, low efficiency of porous membrane-forming technology, poor mechanical properties of membranes, etc., and achieves good porous frame structure, The effect of improving hole forming efficiency and improving mechanical properties

Active Publication Date: 2022-01-25
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the porous film-forming techniques of these methods are often inefficient, the mechanical properties of the film are poor, and they are not suitable for large-scale processing.

Method used

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  • Preparation method and application of porous alginate membrane
  • Preparation method and application of porous alginate membrane
  • Preparation method and application of porous alginate membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Dissolve 0.3g of sodium alginate in 10mL of pure water and let it stand for 12h for defoaming. Take 0.5mL of sodium alginate solution and pour it into a flat-bottomed sample dish, and spread it flat with a thickness of 0.5mm. Then put the sample dish into a freezer and freeze it at -80°C for 2 hours. In addition, to prepare a thawing coagulant, mix 94g of absolute ethanol, 5g of anhydrous calcium chloride, 0.5g of glycerin, and 0.5g of water, and stir to dissolve at room temperature. Then, 2.5 mL of thawing coagulant was injected into the frozen sodium alginate solution, and it was thawed and cross-linked and solidified at -20°C for 6 hours. Thereafter, the porous alginate membrane is taken out, rinsed with pure water, and air-dried at 20°C. The resulting porous alginate membrane has a thickness of about 0.5 mm, is soft and porous (see figure 1 with figure 2 ). from figure 1 It can be seen that the alginate membrane has high porosity and uniform distribution. mag...

Embodiment 2

[0029] Dissolve 0.5g of sodium alginate in 10mL of pure water, and vacuum defoam for 6h. Take 1mL of sodium alginate solution and pour it into a flat-bottomed sample dish, and spread it flat with a thickness of 1mm. Then put the sample dish into a freezer and freeze it at -20°C for 5h. In addition, to prepare a thawing coagulant, mix 75g of absolute ethanol, 20g of anhydrous calcium chloride, 2g of glycerin, and 3g of water, and stir to dissolve at room temperature. Then, 3 mL of thawing coagulant was injected into the frozen sodium alginate solution, and it was thawed and cross-linked and solidified at -20°C for 8 hours. Afterwards, the porous alginate membrane is taken out, rinsed with pure water, and vacuum-dried at 50°C. The obtained porous alginate membrane has a thickness of about 1mm, is soft and porous. The pore structure characteristics of the porous alginate membrane obtained in this example are similar to those in Example 1 (see image 3 with Figure 4 ). The w...

Embodiment 3

[0031] Dissolve 0.7g of sodium alginate in 10mL of pure water, and vacuum defoam for 12h. Take 2mL of sodium alginate solution and pour it into a flat-bottomed sample dish, make it flow-cast flat, with a thickness of 2mm, and then put the sample dish into a freezer and freeze it at -80°C for 3h. In addition, to prepare a thawing coagulant, mix 85g of absolute ethanol, 10g of anhydrous calcium chloride, 2g of glycerin, and 3g of water, and stir to dissolve at room temperature. Then, 20 mL of thawing coagulant was injected into the frozen sodium alginate solution, and it was thawed and cross-linked and solidified at -80°C for 12 hours. Afterwards, the porous alginate membrane is taken out, rinsed with pure water, and vacuum-dried at 25°C. The obtained porous alginate membrane has a thickness of about 2mm, is soft and porous, has good liquid absorption and moisturizing effect, and can be used for wound dressings, hemostatic sponges or cell scaffolds.

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Abstract

The invention discloses a preparation method and application of a porous alginate membrane, wherein the method comprises the following steps: freezing and solidifying a sodium alginate solution at low temperature, and injecting a low-melting-point unfreezing coagulator into the sodium alginate solution, the unfreezing coagulator comprises the following components in percentage by mass: 50-94% of absolute ethyl alcohol, 5-25% of anhydrous calcium chloride, 0.5-2% of glycerol and water; and the ice crystal structure of the sodium alginate macromolecules is gradually dissolved through ethanol permeation, meanwhile, the sodium alginate macromolecules during unfrozen are rapidly cross-linked and solidified through liquefied calcium ions, and the space structure of the frozen state of the sodium alginate macromolecules is reserved, so that a porous alginate film is formed. According to the preparation method, equipment and process conditions are simple, the pore-forming efficiency is greatly improved, the mechanical property of the porous alginate film is improved, and the preparation method is suitable for large-scale processing. In addition, the porous alginate film prepared by the invention can be used for facial masks, wound dressings, hemostatic sponges or cell scaffolds.

Description

technical field [0001] The invention belongs to the field of natural polymer materials, and in particular relates to a preparation method and application of a porous alginate membrane. Background technique [0002] Sodium alginate is a natural polysaccharide polymer compound, which is similar to the proteoglycan structure in human extracellular matrix, and has good biocompatibility, biodegradability, safety and non-toxicity. These excellent properties make sodium alginate widely used in beauty care products, medical and sanitary products, and tissue engineering scaffolds. [0003] In the prior art, the preparation methods of alginate membrane mainly include hydrogel method, freeze-drying method and electrospinning method, wherein the freeze-drying method and electrospinning method make porous alginate membrane. Patent CN109675089A discloses that after blending alginate, gelatin and nanocellulose, it is cast and dried to form a film, then cross-linked with calcium chloride s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/28C08J5/18C08L5/04C08B37/04A61K8/73A61K8/02A61Q19/00A61L15/42A61L15/28A61L24/08A61L24/00A61L27/56A61L27/60
CPCC08J9/28C08J5/18C08B37/0084A61K8/733A61K8/0212A61Q19/00A61L15/425A61L15/28A61L24/08A61L24/0036A61L27/56A61L27/60A61L27/20C08J2201/0484C08J2207/10C08J2207/12C08J2305/04A61L2400/04C08L5/04
Inventor 汪涛肖晓蝶刘子逸
Owner SOUTHWEST UNIV
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