Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for evaluating palatability of coated enrofloxacin by measuring encapsulation efficiency

A technology of encapsulation rate and palatability, which is applied in the field of medicine and chemical industry, can solve the problems affecting pig feed intake and achieve good reproducibility, maintain temperature and stirring speed, high stability and repeatability

Pending Publication Date: 2022-01-21
XINCHANG HEBAO BIOTECH
View PDF15 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the coating effect of enrofloxacin will directly affect the feed intake of pigs

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for evaluating palatability of coated enrofloxacin by measuring encapsulation efficiency
  • Method for evaluating palatability of coated enrofloxacin by measuring encapsulation efficiency
  • Method for evaluating palatability of coated enrofloxacin by measuring encapsulation efficiency

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Use reagents:

[0025] Acetonitrile;

[0026] 2. Triethylamine;

[0027] 3. Phosphoric acid;

[0028] 4. Purification water;

[0029] 5. Sodium hydroxide;

[0030] 6. Sodium phosphate.

[0031] Pre-tuning reagent:

[0032] 1. Phosphate solution: Take 6.805 g of sodium phosphate and 0.88 g of sodium hydroxide, add water to 1000 mL, and adjust the pH to 6.86 with 2 mol / L of sodium hydroxide solution or dilute phosphoric acid solution.

[0033] 2. Mobile phase: The phosphoric acid solution of 0.025 mol / L was adjusted by triethylamine to a pH of 3.0, and then the acetonitrile and the phosphoric acid solution were mixed in volume ratio of 17:83.

[0034] Use the instrument:

[0035] 1. Generally used glassware commonly used in the laboratory;

[0036] 2. Dissolution meter;

[0037] 3. High performance liquid chromatography.

[0038] Experimental steps:

[0039] a) Preparation of sample solution:

[0040] A 500.0 ml of a phosphate solution was quantified and placed in a disso...

Embodiment 2

[0058] Add 1.016 g of the coated Ennovia (Xinchang and Baosheng Technology Co., Ltd.) and stirring. Others in the same embodiment.

[0059] The calculation results are shown in Table 2 below:

[0060]

[0061] Table 2 Embodiment of the encapsulation rate test results

Embodiment 3

[0063] Takenno Sand 0.5mg, 1.0 mg and 1.5 mg of 6 copies, and added to the dissolution cup, and the recovery measurement was carried out according to the establishment method, and the results were as follows:

[0064] Add amount Recovery rate(%) Variation coefficient (n = 6) 0.5mg 85.3、78.9、80.4、83.2、84.1、86.5 3.5％ 1.0mg 88.7、89.9、91.3、86.2、87.9、92.1 2.5％ 1.5mg 97.3、95.2、96.4、93.8、98.7、94.8 1.9％

[0065] Table 3 method of recovery rate test results

[0066] Referring to Table 3, the average recovery rate is between 78.9-98.7%, between 1.9-3.5%, indicating that this method has better recovery, stability and repetition, fully meet the packaged Enno Sand Daily inspection requirements for star package levels.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
recovery rateaaaaaaaaaa
coefficient of variationaaaaaaaaaa
Login to View More

Abstract

The invention discloses a method for evaluating palatability of coated enrofloxacin by measuring the encapsulation efficiency. The method comprises the following steps: a) preparing a sample solution, namely dissolving to-be-tested coated enrofloxacin by adopting a phosphate solution, performing stirring and filtering filtrate to obtain the sample solution, and recording the concentration as C sample; b) preparing a reference substance solution, namely dissolving standard enrofloxacin by adopting a phosphate solution, performing stirring to obtain the reference substance solution, and recording the concentration as C reference; c) carrying out high performance liquid chromatography detection: respectively injecting the sample solution prepared in the step a) and the reference substance solution prepared in the step b) into a high performance liquid chromatograph, recording a chromatogram, respectively recording the peak area A sample of the sample solution and the peak area A reference of the reference substance solution according to an external standard method, and d) carrying out calculating. According to the method, the palatability of the coated enrofloxacin is evaluated by measuring the encapsulation efficiency, and the recovery rate, stability and repeatability of the test method are relatively high, so that the quality control of the coated enrofloxacin product can be realized.

Description

[Technical field] [0001] The present invention relates to the technical field of pharmaceutical chemical technology, in particular, a technical field of evaluating a method of assessing the preparation of Enovoroxacin by determination of the encapsulation rate. 【Background technique】 [0002] Enno Shaxing, also known as ethylcyclopropoxicle or Ethifier star, system named 1-cyclopropyl -7- (4-ethyl-1-piperazinyl) -6-fluoro-1, 4 - Dihydro-4-oxo-3-quinoline carboxylic acid is a special antibacterial drug specified by the designated third-generation quinolones. Although Enoviaxia is often used in livestock and aquatic products, it is hardly used in pig mouth due to taste. In order to solve this phenomenon, people will be treated by Enoviarddra. However, the package of the package of Ennohaxard will directly affect the food's feeding effect. Therefore, the method of coating the effect of Ennohaxard is very urgent. [Summary] [0003] It is an object of the present invention to solve t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/14G01N30/34
CPCG01N30/02G01N30/06G01N30/14G01N30/34G01N2030/047
Inventor 李达焱刘辉刘文超王卫萍
Owner XINCHANG HEBAO BIOTECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com