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Double-network hydrogel film with single-side hydrophobicity and preparation method thereof

A hydrogel, hydrophobic technology, applied in the direction of human tubular structure devices, prostheses, tissue regeneration, etc., can solve the problem of restricting cell growth in the exchange of nutrients and cell waste, controlling porosity, microstructure and pore connection difficulties and other problems, to achieve the effect of preventing bacterial infection, good toughness, and promoting tissue repair.

Active Publication Date: 2022-01-21
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] In urology, the problem of urethral repair has always been one of the thorniest problems for clinical surgeons. Congenital deformities, inflammation, trauma or tumors and other diseases cause urethral damage, stenosis or defect, which needs to be repaired and reconstructed accordingly. With the development of medical level, alternative materials such as autologous skin, mucous membrane and tissue engineering scaffolds have been widely used, which can provide the necessary support structure and pores for cells, but traditional tissue engineering technology has problems in controlling porosity, microstructure and pore junction Difficulty, which limits cell ingrowth and exchange of nutrients with cellular waste

Method used

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  • Double-network hydrogel film with single-side hydrophobicity and preparation method thereof
  • Double-network hydrogel film with single-side hydrophobicity and preparation method thereof
  • Double-network hydrogel film with single-side hydrophobicity and preparation method thereof

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preparation example Construction

[0033] A method for preparing a double-network hydrogel film with one-sided hydrophobicity according to the present invention comprises the following steps:

[0034] Step 1. Prepare polymer material polyvinyl alcohol (PVA) and natural hydrogel material chitosan (CS) respectively into solutions, including dissolving PVA particles in deionized water, and heating in a water bath at 90°C for 1 hour to fully stir In solution state, CS powder is dissolved in 0.2% acetic acid solution to form 5% chitosan acetic acid solution, and the PVA solution and CS acetic acid solution are fully mixed according to the ratio of 4:1, 6:1, or 8:1.

[0035]Step 2. Stir and mix 70% phytic acid solution and magnesium chloride hexahydrate in a ratio of 6:1, add the configured magnesium phytate solution to the mixed sol in step 1 at room temperature, after mixing and stirring, adjust the pH with NaOH aqueous solution After 6-8 days, the solution was statically dripped onto the center of the petri dish, ...

Embodiment 1

[0041] (1) Dissolve 14g of PVA particles in 40ml of deionized water, and heat it in a water bath at 90°C for 1.5h to fully magnetically stir it into a solution state, dissolve 3.5g of CS powder in 10ml of 0.2% acetic acid solution, and add 40ml of deionized water in After magnetically stirring at room temperature for 30 minutes to dissolve into a solution, PVA and CS were fully mixed and left to magnetically stir for 1 hour at 40°C.

[0042] (2) Stir and mix 58mg of phytic acid solution and 75mg of magnesium chloride hexahydrate, add the configured magnesium phytate solution to the mixed sol in step 1 at room temperature, and add 3ml of 0.1mol / ml NaOH aqueous solution to adjust the pH to 6 After mixing well, drop the solution statically onto the center of the petri dish, and spin coat it at a speed of 800r / min for 1min with a spin coater until the solution evenly spreads the petri dish.

[0043] (3) Add 10ml of 30mg / ml dopamine monomer aqueous solution into the mixed solution,...

Embodiment 2

[0047] (1) Dissolve 12g of PVA particles in 50ml of deionized water, and heat it in a water bath at 90°C for 1 hour to fully magnetically stir it into a solution state, dissolve 2g of CS powder in 10ml of 0.2% acetic acid solution, and add 30ml of deionized water at room temperature Magnetically stirred for 30 minutes to dissolve into a solution, and then PVA and CS were fully mixed and left to magnetically stir for 1 hour at 40°C.

[0048] (2) Stir and mix 116mg of phytic acid solution and 150mg of magnesium chloride hexahydrate, add the configured magnesium phytate solution to the mixed sol in step 1 at room temperature, and add 5ml of 0.1mol / ml NaOH aqueous solution to adjust the pH to 6 After mixing well, drop the solution statically onto the center of the petri dish, and spin coat it at a rate of 700r / min for 1min with a spin coater until the solution evenly spreads the petri dish.

[0049] (3) Add 10ml of 50mg / ml dopamine monomer aqueous solution into the mixed solution,...

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Abstract

The invention discloses a double-network hydrogel film with single-side hydrophobicity and a preparation method thereof. The film comprises a hydrogel inner layer A, a fatty acid monoglyceride middle layer B and a single-side hydrophobic outer layer C. The preparation method comprises the following steps: physically cross-linking polyvinyl alcohol and a chitosan solution, adding magnesium phytate as a stimulation reactant into the polyvinyl alcohol and the chitosan solution, paving hydrogel on a culture dish by using a spin coating method, adding a dopamine solution before solidification, standing, and performing freezing and unfreezing circulation to form a dual-network hydrogel system; soaking the hydrogel in the prepared glycerol monolaurate film forming liquid to form a middle antibacterial transition layer; spin-coating a polyurethane / organic silicon modified polymer on a single surface of the middle antibacterial transition layer to form a hydrophobic outer layer, and then drying at room temperature to form a hydrogel film integrating antibacterial property, proper mechanical property, good biocompatibility and proper degradation rate.

Description

technical field [0001] The invention relates to chemical materials and a preparation method, in particular to a double-network hydrogel film with one-sided hydrophobicity and a preparation method thereof. Background technique [0002] In urology, the problem of urethral repair has always been one of the thorniest problems for clinical surgeons. Congenital deformities, inflammation, trauma or tumors and other diseases cause urethral damage, stenosis or defect, which needs to be repaired and reconstructed accordingly. With the development of medical level, alternative materials such as autologous skin, mucous membrane and tissue engineering scaffolds have been widely used, which can provide the necessary support structure and pores for cells, but traditional tissue engineering technology has problems in controlling porosity, microstructure and pore junction Difficulty, which limits cell ingrowth and the exchange of nutrients and cellular waste. [0003] At present, biodegrada...

Claims

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Application Information

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IPC IPC(8): A61L27/20A61L27/16A61L27/18A61L27/52A61L27/54A61L27/56A61L27/58A61F2/04
CPCA61L27/20A61L27/16A61L27/18A61L27/56A61L27/54A61L27/58A61L27/52A61F2/04A61L2300/216A61L2300/404A61L2430/22A61F2002/047C08L5/08C08L29/04C08L79/04C08L83/04C08L75/04
Inventor 白晶叶昕王先丽程兆俊薛烽
Owner SOUTHEAST UNIV
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