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Anti-malassezia traditional Chinese medicine composition and application thereof

A Malassezia and composition technology, which is applied in the field of anti-Malassezia traditional Chinese medicine compositions, can solve the problems of hair fading, dry hair, drug resistance and the like, and achieves low drug resistance, few side effects and low cost Effect

Active Publication Date: 2022-01-04
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ketoconazole has a very high efficiency, but can develop drug resistance
The third category is scalp cell growth inhibitors. By inhibiting the replication of cells, the cells can return to the normal length of the regeneration cycle, thereby improving dandruff problems. The common drug is selenium disulfide, which is widely used clinically, but the hair is easy to change after use. dryness, and may cause hair to fade

Method used

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  • Anti-malassezia traditional Chinese medicine composition and application thereof
  • Anti-malassezia traditional Chinese medicine composition and application thereof
  • Anti-malassezia traditional Chinese medicine composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 The drug susceptibility test of some Chinese herbal decoction pieces to Malassezia restricted and Malassezia furfur

[0034] 1. Materials and Instruments

[0035] 1.1 Strains

[0036]The standard strain of Malassezia restricta in this experiment is Malassezia restricta (Malassezia restricta) CICC31847, purchased from China Industrial Microorganism Culture Collection and Management Center; the standard strain of Malassezia furfur is Malassezia furfur (Malassezia furfur ) GDMCC 2.181, purchased from Guangdong Microbial Culture Collection Center.

[0037] 1.2 Drugs

[0038] Table 1 medicinal material information

[0039]

[0040]

[0041] 1.3 Reagents

[0042] Malt extract (Guangdong Huankai Biotechnology Co., Ltd.), yeast extract (Guangdong Huankai Biological Technology Co., Ltd.), Tween 40 (McLean), glyceryl monostearate (McLean), glucose (Tianjin Zhiyuan Chemical Reagent Co., Ltd.), peptone (Guangdong Huankai Biotechnology Co., Ltd.), olive oil (McL...

Embodiment 2

[0086] The bacteriostasis drug effect of the Sanhua medicine liquid of embodiment 2 different king drug ratio and concentration to Malassezia

[0087] 1. Materials and Instruments

[0088] 1.1 Strains

[0089] The standard strain of Malassezia restricta in this experiment is Malassezia restricta (Malassezia restricta) CICC31847, purchased from China Industrial Microorganism Culture Collection and Management Center; the standard strain of Malassezia furfur is Malassezia furfur (Malassezia furfur ) GDMCC 2.181, purchased from Guangdong Microbial Culture Collection Center.

[0090] 1.2 Drugs

[0091] With embodiment 1 (table 1).

[0092] 1.3 Reagents

[0093] Malt extract (Guangdong Huankai Biotechnology Co., Ltd.), yeast extract (Guangdong Huankai Biological Technology Co., Ltd.), Tween 40 (McLean), glyceryl monostearate (McLean), glucose (Tianjin Zhiyuan Chemical Reagent Co., Ltd.), peptone (Guangdong Huankai Biotechnology Co., Ltd.), olive oil (McLean), agar (Tianjin Zhiy...

Embodiment 3 3

[0158] Example 3 Antibacterial effect of Sanhua lotion on guinea pig skin Malassezia infection model

[0159] 1. Experimental materials and methods

[0160] 1.1 Experimental animals and strains:

[0161] 40 white SPF guinea pigs, 320g-350g, male, were raised by the animal room of Guangzhou University of Traditional Chinese Medicine, and raised under the condition of room temperature 25±2°C.

[0162] The standard strain of Malassezia furfur was Malassezia furfur (Malassezia furfur) GDMCC 2.181, which was purchased from Guangdong Microbial Culture Collection Center.

[0163] 1.2 Main reagents and equipment

[0164] 1.2.1 Main reagents

[0165] Sanhua lotion Chinese medicine stock solution: 0.2g crude drug / ml, 0.4g crude drug / ml (the preparation method is the same as 2.1.2 in Example 2), sterilized in an autoclave, and stored at 4°C for later use.

[0166] Ketoconazole stock solution: Ketoconazole powder is produced by Xi'an Janssen Pharmaceutical Co., Ltd., with a content of...

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Abstract

The invention discloses an anti-malassezia traditional Chinese medicine composition and application thereof. The anti-malassezia traditional Chinese medicine composition comprises the following components in parts by mass: 36-80 parts of rose, 36-80 parts of China rose, 36-80 parts of campsis grandiflora, 20 parts of radix sophorae flavescentis, 15 parts of rhizoma atractylodis, 30 parts of dandelion, 8 parts of angelica sinensis, 12 parts of radix paeoniae rubra, 30 parts of cacumen platycladi, 30 parts of cortex lycii radicis, 15 parts of white mulberry root-bark and 6 parts of green tea. According to the invention, in-vitro experiments show that a traditional Chinese medicine preparation prepared from the traditional Chinese medicine composition can remarkably inhibit malassezia, such as malassezia furfur and malassezia restricta, so that the traditional Chinese medicine preparation can be used for preventing and treating malassezia infection, has the characteristics of few side effects, small drug resistance, low cost, safety, stability and reliability, and has good clinical application prospect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, in particular to an anti-Malassezia traditional Chinese medicine composition and its application. Background technique [0002] Dandruff is a large amount of desquamation caused by the excessive proliferation of scalp keratinocytes. It is a chronic, recurring and relatively common scalp problem. It is medically called "seborrheic dermatitis". The clinical manifestations are excessive small off-white dry or slightly greasy chaff-like flakes on the scalp or hair, which may be accompanied by itching, and the incidence rate is high in the crowd. The generation of dandruff is mainly caused by Malassezia restrictica and Malassezia globosa, and Malassezia restrictica is the main dominant species, which can destroy the microenvironment of the scalp and lead to the metabolic disorder of epidermal cells on the head , producing a lot of dandruff. Dandruff generally begins in adolescen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61K9/08A61P31/10A61P17/00A61P17/08A61P17/04A61K8/9789A61Q5/02A61Q5/00A61Q17/00
CPCA61K36/738A61K36/185A61K36/489A61K36/284A61K36/288A61K36/232A61K36/71A61K36/65A61K36/14A61K36/815A61K36/605A61K36/82A61K9/08A61K9/0014A61P31/10A61P17/00A61P17/08A61P17/04A61K8/9789A61Q5/02A61Q5/006A61Q17/00A61K2236/333A61K2800/805A61K2300/00Y02A50/30
Inventor 张军曹梦飞钟廉杨馥桢陈观凤黄丰科陈泽伟肖妮
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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