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Viscous nanofiber hydrogel dressing capable of being peeled on demand and preparation method thereof

A nanofiber and nanofiber membrane technology, applied in the field of auxiliary materials and their preparation, can solve the problems of insufficient tissue viscosity, wound damage, and inability to peel off painlessly on demand, and achieve the effect of accelerating the healing process.

Inactive Publication Date: 2021-12-28
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide a viscous nanofiber hydrogel dressing that can be peeled off on demand and its preparation method, so as to overcome the lack of tissue viscosity of the prior art nanofiber hydrogel dressing, which usually requires secondary fixation, and cannot meet the requirements. During the movement of the human body, the dressing is firmly adhered to the skin
And the existing sticky dressing usually causes secondary damage to the wound when it is peeled off, and it cannot be painlessly peeled off on demand when changing the dressing, and it cannot be repeatedly adhered and reused.

Method used

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  • Viscous nanofiber hydrogel dressing capable of being peeled on demand and preparation method thereof
  • Viscous nanofiber hydrogel dressing capable of being peeled on demand and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The preparation method of the viscous nanofiber hydrogel dressing that can be peeled off on demand, the specific steps are as follows:

[0041] (1) Dissolve gelatin in a mixed solution of deionized water and acetic acid (mass ratio: 5:2), the mass fraction of gelatin is 30wt%, then stir the mixed solution in a water bath at 30°C for 30min, and heat up to 50°C to continue Stir until completely dissolved.

[0042] (2) Add dopamine (DA) to the above solution, stir for 1 hour in a dark environment until the solution is uniform, then add cystamine dihydrochloride and continue stirring for 1 hour until the solution is uniform, and finally add the coupling agent EDC (1-(3- Dimethylaminopropyl)-3-ethylcarbodiimide) / NHS (N-hydroxysuccinimide), stirred at room temperature for 2h until the solution was uniform, and a stable precursor spinning solution was obtained. The mass fractions of dopamine and cystamine dihydrochloride are 1wt%, 2wt%, respectively, EDC (1-(3-dimethylaminopr...

Embodiment 2

[0047] The preparation method of the viscous nanofiber hydrogel dressing that can be peeled off on demand, the specific steps are as follows:

[0048](1) Dissolve chitosan in a mixed solution of deionized water and oxalic acid (mass ratio is 5:2.5), the mass fraction of chitosan is 25wt%, and then the mixed solution is stirred in a water bath at 30°C for 1h , heated to 50°C and continued to stir until completely dissolved.

[0049] (2) Add tannic acid to the above solution, stir for 1.5h in a dark environment until the solution is uniform, then add cystamine dihydrochloride and continue stirring for 1.5h until the solution is uniform, and finally add the coupling agent EDC (1-(3 -Dimethylaminopropyl)-3-ethylcarbodiimide) / NHS (N-hydroxysuccinimide), stirred at room temperature for 3h until the solution was uniform, and a stable precursor spinning solution was obtained. The mass fractions of tannic acid and cystamine dihydrochloride were 0.5wt%, 1wt%, respectively, EDC (1-(3-di...

Embodiment 3

[0054] The preparation method of the viscous nanofiber hydrogel dressing that can be peeled off on demand, the specific steps are as follows:

[0055] (1) Dissolve methacrylic anhydride gelatin in a mixed solution of deionized water and glacial acetic acid (mass ratio is 5:3), the mass fraction of methacrylic anhydride gelatin is 20wt%, then mix the solution at 30 Stir in a water bath at ℃ for 2h, raise the temperature to 50℃ and continue stirring until completely dissolved.

[0056] (2) Add tea polyphenols to the above solution, stir for 1 hour in a dark environment until the solution is uniform, then add cystamine dihydrochloride and continue stirring for 2 hours until the solution is uniform, and finally add the coupling agent EDC (1-(3-di Methylaminopropyl)-3-ethylcarbodiimide) / NHS (N-hydroxysuccinimide), stirred at room temperature for 4h until the solution was uniform, and a stable precursor spinning solution was obtained. The mass fractions of tea polyphenols and cysta...

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Abstract

The invention relates to a viscous nanofiber hydrogel dressing capable of being peeled on demand and a preparation method thereof. An auxiliary material is prepared from raw materials containing a natural polymer material, a catechol compound, cystamine dihydrochloride and a coupling agent through electrostatic spinning and post-treatment. According to the method disclosed by the invention, nanofiber hydrogel is endowed with excellent mechanical strength and adhesion performance, and when the dressing is replaced or removed, the dressing can be easily stripped without pain by dropwise adding water on the adhesive dressing tightly attached to the skin, and secondary injury to a wound is avoided. The removed dressing is placed in the air to evaporate certain moisture, and when the moisture content of the dressing is about 150%, the dressing still has viscidity, so that repeated adhesion is achieved, and the service life of the dressing is prolonged.

Description

technical field [0001] The invention belongs to the field of auxiliary materials and preparation thereof, in particular to a viscous nanofiber hydrogel dressing that can be peeled off on demand and a preparation method thereof. Background technique [0002] According to statistics, about hundreds of millions of people around the world suffer from skin trauma every year due to natural disasters, accidents or operations. Ineffective treatment of skin injuries can lead to disability or even death. As one of the most common medical consumables in clinical practice, skin dressing has the functions of protecting wound surface, anti-inflammatory and hemostasis. In order to achieve effective wound care, skin dressings also need to have good biocompatibility, certain mechanical properties, adhesion to the skin, and biodegradability. Nanofibers prepared by electrospinning technology have excellent properties such as large specific surface area and porosity. Therefore, they have attra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00D06M13/322D06M13/418D01F4/00D01F1/10D04H1/728D06M101/14
CPCA61L26/008A61L26/0061A61L26/0066A61L26/0038A61L26/0023A61L26/0033D06M13/322D06M13/418D01F4/00D01F1/10D04H1/728D06M2101/14A61L2400/12A61L2300/412A61L2400/04C08L5/08C08L5/04
Inventor 李晓然耿影俞建勇丁彬
Owner DONGHUA UNIV
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