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Antibacterial coating with pH response function, functional material with antibacterial coating and preparation method of functional material

A technology of antibacterial coating and functional material, which is applied in the field of functional material of antibacterial coating and its preparation, can solve the problems of high biological toxicity, reduced bactericidal effect, inflammation and immune response, etc., achieve good biocompatibility, reduce cell Toxicity, firm coating effect

Active Publication Date: 2021-12-17
WEIGAO HLDG +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Actively attacking surfaces often suffers from problems related to the accumulation of dead bacteria and debris, which not only shields functional groups, thereby reducing the bactericidal effect, but also acts as a conditioning film to provide nutrients for subsequent bacterial adhesion, resulting in an immune response or inflammation
At the same time, the biological toxicity is high, and it is easy to cause inflammation and immune response in the body

Method used

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  • Antibacterial coating with pH response function, functional material with antibacterial coating and preparation method of functional material
  • Antibacterial coating with pH response function, functional material with antibacterial coating and preparation method of functional material
  • Antibacterial coating with pH response function, functional material with antibacterial coating and preparation method of functional material

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preparation example Construction

[0133] The present invention provides a method for preparing a functional material with an antibacterial coating described in any one of the above technical solutions, characterized in that it comprises the following steps:

[0134] 1) The monomer with R structure, with R 1 After the monomer of the structure is reacted with the first solvent, the first polymer intermediate is obtained after precipitation;

[0135] 2) the first polymer intermediate obtained in the above steps, having R 2 Monomer haloalkane with X structure, with R 3 After the alkyl halide of X structure reacts with the first solvent again, the second polymer intermediate is obtained after precipitation; wherein, X is selected from Cl, Br or I;

[0136] 3) After deprotecting the second polymer intermediate obtained in the above steps, trifluoroacetic acid and the second solvent, a third polymer intermediate is obtained;

[0137] 4) the third polymer intermediate obtained in the above steps, specifically R 4 Af...

Embodiment 1

[0177] Preparation of Adaptive Medical Antimicrobial Catheter:

[0178] (1) Preparation of zwitterionic polymers:

[0179] Take 0.52g of ethylene glycol glycidyl ether and 0.64g of N-tert-butoxycarbonyl ethylenediamine in dimethyl sulfoxide as a solvent and react at 60°C for 8 hours, then diethyl ether precipitates, and after vacuum drying for 24 hours, take 500mg and 1mL of hexyl bromide and 100mg of 3-bromobenzophenone was reacted in dimethyl sulfoxide solvent at 45°C for 24h. After the reaction, diethyl ether precipitated and dried in vacuo. Finally, 500mg of the product was dissolved in 10mL of dichloromethane, and 3mL of trifluoroacetic acid was added and stirred at 25°C. Remove the protective group for 8 hours, and finally take 500 mg of the polymer that has removed the BOC protection and dissolve it in 20 mL of N,N-dimethylformamide solution, add 100 mg of maleic anhydride, stir magnetically at 50°C for 24 hours, and dialyze in a 3500Da dialysis bag for 24 hours , to o...

Embodiment 2

[0185] (1) Preparation of zwitterionic polymers:

[0186] Take 0.48g of diglycidyl ether and 0.71g of N-tert-butoxycarbonyl-1,3-propanediamine in N,N-dimethylacetamide at 80°C for 6h, then diethyl ether precipitates, after vacuum drying for 24h, take 500mg and 1.2 mL of bromododecane and 85 mg of 4-bromobenzoylbenzene were reacted in N,N-dimethylacetamide at 50°C for 24 hours. After the reaction, n-hexane precipitated and dried in vacuum. Finally, 500 mg of the product was dissolved in 10 mL of di Chloromethane, add 2.2mL trifluoroacetic acid and stir at room temperature for 12h to remove the protective group, finally take 500mg of the polymer removed from BOC protection and dissolve it in 20mL dimethyl sulfoxide solution, add 2,3-dimethylmale 115 mg of acid anhydride, magnetically stirred at 55°C for 24 hours, and dialyzed in a 3500 Da dialysis bag for 24 hours to obtain a zwitterionic polymer. .

[0187] (2) Preparation of coating solution:

[0188] Take 1g of the polymer...

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Abstract

The invention provides an antibacterial coating. The antibacterial coating comprises a zwitterionic polymer with a structure as shown in a formula (I). The polymer designed by the invention has a pH-responsive functional group. In an acidification environment caused by bacteria, the structure of the responsive functional group is changed and a negative electricity group is removed, at the moment, the polymer shows positive electricity, the polymer shows antibacterial property, and effective sterilization aiming at the bacterial micro-environment is realized. In addition, a benzophenone derivative is introduced into the polymer as a photocuring or crosslinking group, and firm coating of the polymer on the surface of medical equipment can be achieved. According to the self-adaptive antibacterial coating provided by the invention, a photocuring group and a zwitterionic group are combined to construct a zwitterionic polymer, and the dual functions of adhesion resistance and responsive antibacterial property are realized through the polymer. The preparation process is simpler, low in equipment requirement, easy to operate and high in feasibility.

Description

technical field [0001] The invention belongs to the field of antibacterial medical devices, and relates to an antibacterial coating, a functional material with an antibacterial coating and a preparation method thereof, in particular to an antibacterial coating with a pH response function and the function of an antibacterial coating with a pH response function Materials and their preparation methods. Background technique [0002] Bacteria are ubiquitous in the environment and in the human body, and pathogenic bacteria that cause human diseases pose a serious threat to public health. The most common bacterial-derived diseases are foodborne diseases, urinary tract infections, sexually transmitted infections, and nosocomial infections. The adhesion, growth and reproduction of bacteria on the surface of materials, and even the formation of biofilms are the main reasons for the failure of implantation of medical materials. Similarly, the adhesion, proliferation and even the forma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09D179/02C09D5/14C08G73/02A61L29/08A61L29/14
CPCC09D179/02C09D5/14C08G73/024A61L29/085A61L29/14A61L2400/18A61L2420/02
Inventor 闫顺杰张桢焱周容涛栾世方万雪孙振龙张帅殷敬华
Owner WEIGAO HLDG
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