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Oxybutynin nanosuspension, composition containing oxybutynin nanosuspension and preparation method of oxybutynin nanosuspension

A kind of nano-suspension, nano-suspension technology, applied in the composition containing oxybutynin nano-suspension, the field of preparation of oxybutynin nano-suspension, to improve solubility and dissolution rate, improve transdermal Good absorption and stability

Active Publication Date: 2021-12-17
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the preparation methods "Bottom-up" and "Top-down" of nanosuspensions have inherent disadvantages. It is another technical problem to choose a suitable preparation method according to the properties of the drug.

Method used

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  • Oxybutynin nanosuspension, composition containing oxybutynin nanosuspension and preparation method of oxybutynin nanosuspension
  • Oxybutynin nanosuspension, composition containing oxybutynin nanosuspension and preparation method of oxybutynin nanosuspension
  • Oxybutynin nanosuspension, composition containing oxybutynin nanosuspension and preparation method of oxybutynin nanosuspension

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Effect test

Embodiment 1

[0031] Weigh oxybutynin, vitamin E succinate and poloxamer 188 (mass ratio is 2:2:1), dissolve in an appropriate amount of absolute ethanol as the organic phase; take 100mL purified water as the water phase; The organic phase was slowly dropped into the water phase under low pressure; then the ethanol was removed by rotary evaporation at 45°C; 800bar high-pressure homogenization was performed 20 times to obtain the oxybutynin nanosuspension. The measured average particle diameter is 179.73±1.28nm, and the PDI is 0.193±0.009.

Embodiment 2

[0033] Weigh oxybutynin, vitamin E succinate and poloxamer 188 (mass ratio is 1:1:1), dissolve in an appropriate amount of absolute ethanol as the organic phase; take 100mL purified water as the water phase; The organic phase was slowly dropped into the water phase under low pressure; then the ethanol was removed by rotary evaporation at 45°C; 800bar high-pressure homogenization was performed 20 times to obtain the oxybutynin nanosuspension. The measured average particle diameter is 190.74±1.59nm, and the PDI is 0.221±0.017.

Embodiment 3

[0035] Weigh oxybutynin, vitamin E succinate and poloxamer 188 (mass ratio 1:1:2), dissolve in an appropriate amount of absolute ethanol as the organic phase; take 100mL purified water as the water phase; The organic phase was slowly dropped into the water phase under low pressure; then the ethanol was removed by rotary evaporation at 45°C; 800bar high-pressure homogenization was performed 20 times to obtain the oxybutynin nanosuspension. The measured average particle diameter is 163.47±1.09nm, and the PDI is 0.114±0.025.

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Abstract

The invention belongs to the field of pharmaceutical preparations, particularly relates to an oxybutynin nanosuspension, a composition containing the oxybutynin nanosuspension and a preparation method of the oxybutynin nanosuspension, and relates to the composition containing the oxybutynin nanosuspension. The oxybutynin nanosuspension is composed of oxybutynin, a stabilizer and a co-stabilizer, the preparation method is simple, and industrial production is facilitated. The composition containing the oxybutynin nanosuspension is oxybutynin nanosuspension freeze-dried powder, oxybutynin nanosuspension gel and oxybutynin nanosuspension hydrogel patch, the stability is better, and the administration is flexible and convenient. After the oxybutynin nanosuspension and the composition containing the oxybutynin nanosuspension are applied to the skin, the transdermal absorption of the oxybutynin can be remarkably improved, and a drug reservoir can be formed in the skin to slowly release drugs.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a preparation method and application of oxybutynin nano-suspension, and to a composition containing oxybutynin nano-suspension. Background technique [0002] Overactive bladder (OAB) is a group of syndromes characterized by symptoms of urinary urgency, urodynamically manifested as detrusor overactivity or other urethral-bladder dysfunction, often accompanied by frequent urination and nocturia, which may be accompanied by or without urge incontinence. Although not fatal, OAB is common in all age groups and its prevalence increases with age. OAB will not only seriously affect the quality of life of patients, but also cause immeasurable psychological impact and huge social and economic burden. [0003] Oxybutynin (OXY) is the third-generation drug of choice for the treatment of urinary incontinence. It has anticholinergic, anti-smooth muscle spasm and local anesthetic ef...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K9/06A61K9/19A61K9/70A61K31/216A61K47/10A61K47/22A61K47/32A61P13/10
CPCA61K31/216A61K9/10A61K9/06A61K9/19A61K9/70A61K47/10A61K47/22A61K47/32A61P13/10
Inventor 吕慧侠张爽盛雨泽
Owner CHINA PHARM UNIV
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