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Composite material with rapid blood coagulation effect and preparation method thereof

A composite material and blood coagulation technology, which is applied in the agricultural field to achieve the effects of enhancing stability, promoting adsorption, and promoting red blood cell aggregation

Active Publication Date: 2021-12-10
GUANGDONG OCEAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such as WoundStat hemostatic agent, there is a risk of entering the blood circulation system and causing peripheral thrombus, etc.

Method used

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  • Composite material with rapid blood coagulation effect and preparation method thereof
  • Composite material with rapid blood coagulation effect and preparation method thereof
  • Composite material with rapid blood coagulation effect and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] A preparation method of a composite material with rapid blood coagulation:

[0048] (1) in the chitosan of 140g (chitosan is molecular weight 100KDa, degree of deacetylation 90%), add 4526g acetic acid aqueous solution (the massfraction of acetic acid in the acetic acid aqueous solution is 2%) and obtain chitosan solution after dissolving.

[0049] (2) After dissolving 120g (0.8688mol) of 2-aminoisonicotinic acid with absolute ethanol (the consumption of absolute alcohol is 20% of the volume of acetic acid aqueous solution in step (1), add 1.3032mol of EDC·HCl and 0.2606 mol of NHS, stirred at room temperature (about 25°C) for 3 hours to obtain a mixed ethanol solution of 2-aminoisonicotinic acid and coupling agent.

[0050] (3) Add the ethanol solution mixed with the 2-aminoisonicotinic acid prepared in step (2) and the coupling agent into the chitosan solution prepared in step (1) and stir at room temperature for 8h, dialyze in distilled water, and freeze-dry to obtai...

Embodiment 2

[0053] (1) add 3840g acetic acid aqueous solution (the massfraction of acetic acid in the acetic acid aqueous solution is 2%) in the chitosan of 160g (chitosan is molecular weight 100KDa, deacetylation degree 90%) obtains chitosan solution after dissolving.

[0054] (2) After dissolving 100g (0.724mol) of 2-aminoisonicotinic acid with absolute ethanol (the consumption of absolute alcohol is 20% of the volume of acetic acid aqueous solution in step (1), add 1.086mol of EDC·HCl and 0.2172 mol of NHS, stirred at room temperature (about 25°C) for 3 hours to obtain a mixed ethanol solution of 2-aminoisonicotinic acid and coupling agent.

[0055] (3) Add the ethanol solution mixed with the 2-aminoisonicotinic acid prepared in step (2) and the coupling agent into the chitosan solution prepared in step (1) and stir at room temperature for 7h, dialyze in distilled water, and freeze-dry to obtain Chitosan-aminoisonicotinic acid graft.

[0056] (4) the chitosan-aminoisonicotinic acid gr...

Embodiment 3

[0058] (1) in the chitosan of 80g (chitosan is molecular weight 100KDa, degree of deacetylation 90%), add 3920g acetic acid aqueous solution (the massfraction of acetic acid in the acetic acid aqueous solution is 2%) and obtain chitosan solution after dissolving.

[0059] (2) After dissolving 80g (0.5792mol) of 2-aminoisonicotinic acid with absolute ethanol (the consumption of absolute alcohol is 30% of the volume of acetic acid aqueous solution in step (1), add 0.8688mol of EDC·HCl and 0.1738 mol of NHS, stirred at room temperature (about 25°C) for 3 hours to obtain a mixed ethanol solution of 2-aminoisonicotinic acid and coupling agent.

[0060] (3) Add the ethanol solution mixed with the 2-aminoisonicotinic acid prepared in step (2) and the coupling agent into the chitosan solution prepared in step (1) and stir at room temperature for 6h, dialyze in distilled water, and freeze-dry to obtain Chitosan-aminoisonicotinic acid graft.

[0061] (4) the chitosan-aminoisonicotinic ...

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Abstract

The invention discloses a composite material with a rapid blood coagulation effect and a preparation method thereof and belongs to the technical field of biological medicines. The composite material with the rapid blood coagulation effect is prepared from the following raw materials in parts by mass: 8 to 20 parts of chitosan, 7 to 14 parts of salicylaldehyde, 8 to 16 parts of 2-aminoisonicotinic acid, 1.5 to 3.5 parts of ferrous sulfate, 3 to 5 parts of dopa and 10 to 15 parts of disodium hydrogen phosphate. The prepared composite material with the rapid blood coagulation effect has good product stability and high biological safety, has a remarkable effect on blood coagulation, and is simple in process and easy to industrially produce.

Description

technical field [0001] The invention relates to the field of agricultural technology, in particular to a composite material with rapid coagulation effect and a preparation method thereof. Background technique [0002] According to statistics, uncontrolled bleeding is the main cause of death, and hemorrhagic shock accounts for 30% to 45% of traumatic injury deaths every year. Therefore, the development of high-efficiency hemostatic materials has become the key to rapid hemostasis and reduction of bleeding mortality. Although hemostatic materials such as glutaraldehyde-crosslinked albumin and fibrin-based bandages have good hemostatic effects, it is difficult for traditional hemostatic agents to control this type of hemostasis in patients with coagulopathy who lack coagulation factors or have dysfunctional hemostasis. Blood loss, which increases the risk of death from massive blood loss. Therefore, controlling hemostasis with coagulopathy bleeding remains a great challenge. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/20A61L15/18A61L15/42A61L15/44A61L15/46C08B37/08
CPCC08B37/003A61L15/28A61L15/44A61L15/46A61L15/20A61L15/18A61L15/425A61L2300/418A61L2300/236A61L2300/214A61L2300/102C08L5/08A61L2400/04A61L24/0089A61L24/0073A61L15/42
Inventor 胡章张兆宇卢思彤黄德坚余佳音程瑜廖铭能
Owner GUANGDONG OCEAN UNIVERSITY
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