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Composite nano-material as well as preparation method and application thereof

A technology of composite nanomaterials and composite agents, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve the problems of inability to diagnose tumors, difficulty in achieving treatment goals, time-consuming and labor-intensive problems, and achieve excellent imaging performance, good magnetic sensitivity, The effect of excellent biocompatibility

Pending Publication Date: 2021-12-03
CIXI INST OF BIOMEDICAL ENG NINGBO INST OF MATERIALS TECH & ENG CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] However, black titanium dioxide alone has only photothermal therapy effect and cannot diagnose tumors. Therefore, it needs to use other tumor diagnosis techniques, which is difficult to achieve efficient treatment purposes, and is time-consuming and laborious.

Method used

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  • Composite nano-material as well as preparation method and application thereof
  • Composite nano-material as well as preparation method and application thereof
  • Composite nano-material as well as preparation method and application thereof

Examples

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preparation example Construction

[0124] A method for preparing a diagnosis and treatment integrated gadolinium-titanium composite nanomaterial (i.e. a contrast / photothermal therapy composite agent), said method comprising the following steps:

[0125] a) Preparation of bTiO 2 Nanoparticles;

[0126] b) Preparation of Gd 2 o 3 -bTiO 2 Composite nanomaterials;

[0127] c) Preparation of Gd 2 o 3 -bTiO 2 -PEG composite nanomaterials;

[0128] d) Preparation of Gd 2 o 3 -bTiO 2 - PEG-GE11 composite nanomaterial, that is, a composite agent for contrast / photothermal therapy.

[0129] In this application, step a) prepares bTiO 2 For nanoparticles, use P25 as raw material, NaBH 4 as a strong reducing agent.

[0130] P25 and NaBH in step a) 4 The mass ratio is 4:1-1:1, preferably 2:1-1:1, more preferably 1:1.

[0131] The grinding time of the grinding in step a) is 10-40 min, preferably 20-40 min, more preferably 40 min.

[0132] The protective gas in step a) is nitrogen or argon.

[0133] The calcin...

Embodiment 1

[0173] (1) Weigh 1.5g of P25 solid, NaBH 4 Put 1.5g of the solid in a mortar, grind for 30 minutes, transfer to a porcelain boat, and react in a tube furnace (reaction conditions: react at 350°C for 3h, the heating rate is 10°C / min, and the protective gas is nitrogen) to obtain bTiO 2 . TiO 2 After natural cooling, put it in deionized water overnight to remove unreacted NaBH 4 , followed by centrifugal washing with 2 water and 2 alcohol for 4 times, dried at 70°C and stored in a 4°C refrigerator.

[0174] (2) Weigh 0.906g of solid NaOH and dissolve it in 90.6ml of DEG. After it is completely dissolved, transfer it to a 250ml three-neck flask, then weigh 0.8mmol of gadolinium nitrate hexahydrate and add it to the above alkaline solution; at the same time, weigh bTiO 2 2mmol, dissolved in 20ml DEG, after being dispersed by a cell breaker, added dropwise to the above mixed solution, and finally adjusted to 160ml with DEG, and placed on a magnetic stirrer for reaction (reactio...

Embodiment 2

[0188] (1) Weigh 3.0g of P25 solid, NaBH 4 Put 1.5g of the solid in a mortar, grind for 30 minutes, transfer to a porcelain boat, and react in a tube furnace (reaction conditions: react at 350°C for 3h, the heating rate is 10°C / min, and the protective gas is nitrogen) to obtain bTiO 2 . TiO 2 After natural cooling, put it in deionized water overnight to remove unreacted NaBH 4 , followed by centrifugal washing with 2 water and 2 alcohol for 4 times, dried at 70°C and stored in a 4°C refrigerator.

[0189] (2) Take by weighing 0.906g of solid NaOH and dissolve it in 90.6ml of DEG (diethylene glycol). After dissolving completely, transfer it to a 250ml three-neck flask, then weigh 0.8mmol of gadolinium nitrate hexahydrate and add it to the above-mentioned alkaline solution. Weigh bTiO 2 2mmol, dissolved in 20ml DEG, after being dispersed by a cell breaker, added dropwise to the above mixed solution, and finally adjusted to 160ml with DEG, and placed on a magnetic stirrer fo...

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Abstract

The invention discloses a composite nano material as well as a preparation method and application thereof. The composite nano material comprises magnetic resonance imaging nano particles and reduced titanium dioxide nano particles; the particle size of the magnetic resonance imaging nano particles is smaller than that of the reduced titanium dioxide nano particles; the magnetic resonance imaging nanoparticles are attached to the surfaces of the reduced titanium dioxide nanoparticles; the reduced titanium dioxide nano particles are titanium dioxide nano particles subjected to reduction treatment. According to the application, T1 magnetic resonance imaging of the magnetic resonance imaging nano particles (such as Gd2O3) and photo-thermal therapy of bTiO2 are integrated together, and the diagnosis and treatment integrated nano-composite is obtained. Early diagnosis, accurate positioning and in-situ treatment of tumors and real-time tracking and prognosis monitoring in the treatment process are expected to be achieved, and the method can be better applied to tumor treatment.

Description

technical field [0001] The application relates to a composite nanomaterial and its preparation method and application, belonging to the field of functional materials. Background technique [0002] Non-invasive and visualized molecular imaging technology can not only reduce the harm to the human body, but also provide effective diagnostic information for various diseases. As a popular molecular diagnostic imaging technology in medicine, MRI has less harm to the human body and more hidden danger Therefore, MRI technology is usually used as the first choice for diagnosis. [0003] In MRI clinical detection, it is necessary to use MRI contrast agents to diagnose diseases, mainly because the introduction of contrast agents can change the relaxation rate of hydrogen protons in local tissues, improve the signal difference between healthy parts and diseased parts, and then Get clear images with different contrasts. At present, MRI contrast agents can be divided into two categories...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/64A61K47/54A61K47/61A61K47/69A61P35/00A61K49/12A61K49/18B82Y5/00B82Y15/00
CPCA61K41/0052A61K47/64A61K47/545A61K47/61A61K47/6935A61P35/00A61K49/126A61K49/186B82Y5/00B82Y15/00
Inventor 陈天翔陈佳马雪华吴爱国
Owner CIXI INST OF BIOMEDICAL ENG NINGBO INST OF MATERIALS TECH & ENG CHINESE ACAD OF SCI
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