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Chitosan/poly [2-(methacryloyloxy)ethyl]trimethyl ammonium chloride hydrogel

A technology of methacryloyloxyethyltrimethylammonium chloride and hydrogel, applied in bandages, surgery, drug delivery, etc., can solve problems such as accelerated wound healing and bacterial film rupture, and promote skin tissue healing , promote wound tissue regeneration, promote the effect of collagen deposition

Active Publication Date: 2021-11-09
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The antibacterial mechanism may be that the cations on the polymer surface bind to the anions on the bacterial membrane, which leads to the rupture of the bacterial membrane
However, PMETACs themselves lack the ability to accelerate wound healing

Method used

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  • Chitosan/poly [2-(methacryloyloxy)ethyl]trimethyl ammonium chloride hydrogel
  • Chitosan/poly [2-(methacryloyloxy)ethyl]trimethyl ammonium chloride hydrogel
  • Chitosan/poly [2-(methacryloyloxy)ethyl]trimethyl ammonium chloride hydrogel

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preparation example Construction

[0034] Further, the preparation method of chitosan / poly 2-methacryloyloxyethyltrimethylammonium chloride hydrogel, the specific steps are as follows:

[0035] (1) Preparation of poly 2-methacryloyloxyethyltrimethylammonium chloride hydrogel: add BAM and I2959 to 2-methacryloyloxyethyltrimethylammonium chloride solution, heat up and stir Make it mix evenly, and obtain poly-2-methacryloyloxyethyltrimethylammonium chloride hydrogel by irradiating the mixed system with ultraviolet light;

[0036] (2) Add chitosan to the acetic acid solution of poly 2-methacryloyloxyethyltrimethylammonium chloride hydrogel in (1), after heating up and stirring, obtain the chitosan by ultraviolet light irradiation Sugar / poly-2-methacryloyloxyethyltrimethylammonium chloride hydrogel.

[0037] Furthermore, the temperature of the heating and stirring is 45-55°C, such as 48°C, 49°C, 50°C or 51°C.

[0038] Furthermore, in the above step (1), the concentration of the 2-methacryloyloxyethyltrimethylammon...

Embodiment 1

[0051] 1. Experimental materials and methods:

[0052] (1) Preparation and characterization of CS / PMETAC hydrogel wound dressing

[0053] 1. Preparation of PMETAC Hydrogel

[0054] METAC (2 g) was dissolved in deionized water (20 mL), then BAM (0.1 g) and I2959 (0.16 g) were added. The solution was stirred at 50°C for 5 minutes. Afterwards, the solution was crosslinked under UV light (365nm, 5w) irradiation.

[0055] 2. Preparation of CS / PMETAC Hydrogel

[0056] METAC (2g) was dissolved in deionized water (20mL) containing acetic acid, then BAM (0.1g), I2959 (0.16g) and chitosan (0.1g, 0.2g, 0.4g) were added, and the solution was added in After stirring at 50° C. for 5 minutes, crosslinking was performed under ultraviolet light (365 nm, 5w) irradiation.

[0057] 3. Characterization of Materials

[0058] Observing the ultrastructure of the composite material through scanning electron microscopy (SEM); analyzing the chemical structure of the material through FTIR (Fourier ...

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Abstract

The invention relates to a chitosan / poly [2-(methacryloyloxy)ethyl]trimethyl ammonium chloride hydrogel. The invention aims to design a hydrogel preparation with a good antibacterial effect. CS, METAC, a cross-linking agent BAM and a photoinitiator I2959 are uniformly mixed; and then polymerization is initiated by ultraviolet light, so that a CS / PMETAC hydrogel wound dressing is formed. Through verification, the hydrogel preparation has good antibacterial property and can promote wound healing; and more importantly, the hydrogel also has good mechanical property and very good self-healing property and rheological property, can be applied to an affected part in an injection form, and greatly expands the clinical application mode as a wound dressing.

Description

technical field [0001] The invention belongs to the technical field of medical dressings, in particular to a chitosan / poly 2-methacryloyloxyethyltrimethylammonium chloride hydrogel, a preparation method of the hydrogel and the hydrogel Applications as antibacterial products or medical dressings. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Wounds on the surface of the skin disrupt the barrier protection function and are susceptible to bacterial infection, which can cause an inflammatory response and lead to prolonged wound healing. Therefore, wound dressings with antimicrobial properties are needed to protect and repair damaged skin. Various wound dressings have been...

Claims

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Application Information

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IPC IPC(8): A61L26/00A61L24/08A61L24/06A61L24/00C08J3/075C08J3/24C08L33/14C08L5/08
CPCC08J3/075C08J3/246A61L26/008A61L26/0066A61L26/0023A61L26/0014A61L24/0031A61L24/0015A61L24/08A61L24/06C08J2333/14C08J2405/08A61L2300/404A61L2300/41A61L2400/06A61L2300/236C08L33/14C08L5/08
Inventor 葛少华于晴邵金龙黄俊闫勇敢梁乾宇王兵李建华
Owner SHANDONG UNIV
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