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Preparation method of artemisia selengensis and scutellaria baicalensis gallbladder-clearing granules

A technology of Haoqin and granules, which is applied in the field of preparation of Haoqin Qingdan granules, which can solve the problems of affecting the quality and curative effect of drugs, the decrease of drug fluidity, mildew, etc., and achieve the inconvenient decoction, rapid action and fast absorption Effect

Active Publication Date: 2021-11-05
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the problem of moisture absorption in the preparation process of traditional Chinese medicine solid preparations has always been a common problem in the development of preparations. After moisture absorption, in addition to softening, agglomeration and even mildew, the fluidity of the drug will also decrease, thereby affecting the quality and efficacy of the drug.

Method used

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  • Preparation method of artemisia selengensis and scutellaria baicalensis gallbladder-clearing granules
  • Preparation method of artemisia selengensis and scutellaria baicalensis gallbladder-clearing granules
  • Preparation method of artemisia selengensis and scutellaria baicalensis gallbladder-clearing granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-3

[0100] Embodiment 1-3 dry granulation

[0101] Talcum powder 4.15g, Indigo 0.7g packed into bags and fried, together with 6g Artemisia annua, Bambusa 9g, Pinellia 4.5g, Chi Fuling 9g, Scutellaria baicalensis 4.5g, Citrus aurantium 4.5g, Tangerine peel 4.5g, licorice 4.15g Mix, add 10 times and 8 times the amount of water to extract twice, each time for 1 hour, filter, concentrate to a clear paste with a relative density of 1.08±0.02 (50°C), centrifuge, and spray dry to obtain Artemisia chinensis gallbladder clear powder. Mix the fine powder of Artemisia chinensis clearing gallbladder obtained by spray drying with 3 different kinds of excipients according to the mass ratio of mixed excipients: fine powder = 5:5, and add 0.5wt% magnesium stearate, mix well, and carry out dry compression granulation , packaging, 8g per bag. Compare the forming rate, melting and hygroscopicity of the granules. Example 1-3 See Table 11 for the proportions of Artemisia chinensis Qingdan fine powde...

Embodiment 4

[0115] Embodiment 4 wet granulation

[0116] Talcum powder 4.15g, Indigo 0.7g packed into bags and fried, together with 6g Artemisia annua, Bambusa 9g, Pinellia 4.5g, Chi Fuling 9g, Scutellaria baicalensis 4.5g, Citrus aurantium 4.5g, Tangerine peel 4.5g, licorice 4.15g Mix, add 10 times and 8 times the amount of water to extract twice, each time for 1 hour, filter, concentrate to a clear paste with a relative density of 1.08±0.02 (50°C), centrifuge, use dextrin as an auxiliary material, and use the thick paste to directly prepare Granules, even if adding 70wt% dextrin, still can not successfully granulate, this method is not feasible.

Embodiment 5

[0117] Embodiment 5 wet granulation

[0118] Talcum powder 4.15g, Indigo 0.7g packed into bags and fried, together with 6g Artemisia annua, Bambusa 9g, Pinellia 4.5g, Chi Fuling 9g, Scutellaria baicalensis 4.5g, Citrus aurantium 4.5g, Tangerine peel 4.5g, licorice 4.15g Mix, add 10 times and 8 times the amount of water to extract twice, each time for 1h, filter, concentrate to a clear paste with a relative density of 1.08±0.02 (50°C), centrifuge, and spray dry to obtain Artemisia chinensis fine gallbladder powder ( Dry paste powder), with dextrin as auxiliary material, dry paste powder and dextrin are mixed, add appropriate amount of ethanol, wet granulation, the impact results of different ethanol concentrations and dextrin dosage on the granulation situation are shown in Tables 13 and 14.

[0119] The investigation of table 13 ethanol concentration

[0120] Numbering ethanol concentration Ethanol consumption / mL Granulation situation 1 95％ 30 qualifie...

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Abstract

The invention discloses a preparation method of artemisia scutellaria and scutellaria baicalensis gallbladder-clearing granules, and relates to the technical field of traditional Chinese medicine preparation. The preparation method comprises the following steps of bagging talcum powder and indigo naturalis, decocting in bags, mixing with artemisia apiacea, bamboo shavings, rhizoma pinellinae praeparata, red poria cocos, scutellaria baicalensis, fructus aurantii, citrus chachiensis hortorum and liquorice, adding water for extraction, filtering, concentrating to obtain clear paste, centrifuging, adding auxiliary materials, drying and granulating to obtain the artemisia-scutellaria and scutellaria baicalensis gallbladder-clearing granules. The granules not only maintain the advantages of quick absorption and quick action of a decoction, but also overcome the defects that the decoction is inconvenient to decoct, large in dosage, easy to mildew and the like when being used temporarily.

Description

technical field [0001] The invention relates to the technical field of preparation of traditional Chinese medicines, in particular to a preparation method of Artemisinin Qingdan Granules. Background technique [0002] Haoqin Qingdan Decoction is the representative prescription of Yu Genchu ​​in "Rebooking Popular Treatise on Febrile Diseases" for the treatment of Shaoyang damp-heat and phlegm turbidity syndrome. It is now widely used clinically for a variety of exogenous febrile diseases, including many infectious diseases in modern medicine, infectious diseases and non-infectious febrile diseases, etc., and is also widely used in bile reflux gastritis, cholecystitis, biliary Calculus, urinary tract infection, typhoid fever, summer high fever dizziness, night sweats and other diseases. However, the oral dose of decoction is large, and it is inconvenient to store and carry. It takes time to decoct clinically, and it is not suitable for the clinical needs of some acute exogen...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P1/00A61P1/16A61P13/02A61P31/00A61K9/16A61K47/36A61K47/26A61K33/12
CPCA61K33/12A61K36/704A61K36/315A61K36/195A61K36/282A61K36/899A61K36/8888A61K36/076A61K36/539A61K36/752A61K36/484A61K9/1652A61K9/1623A61P1/16A61P31/00A61P1/00A61P13/02A61K2236/331A61K2236/51A61K2300/00Y02A50/30
Inventor 田纪祥张东赵晓昂曹春雨
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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