Complex immunopotentiator as well as preparation method and application thereof

A technology of immune enhancer and dosage ratio, which is applied in the field of medicine, can solve the problems of drug administration method and drug combination optimization, agonists have no curative effect, etc., and achieve the effect of enhancing T cell activity, reducing immune escape, and simple implementation process

Pending Publication Date: 2021-11-02
NANJING DRUM TOWER HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The possible reason why OX40 agonists did not exert their due curative effect is that the administration method and drug combination were not optimized

Method used

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  • Complex immunopotentiator as well as preparation method and application thereof
  • Complex immunopotentiator as well as preparation method and application thereof
  • Complex immunopotentiator as well as preparation method and application thereof

Examples

Experimental program
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Embodiment Construction

[0036] The present invention will be further described below in conjunction with specific examples.

[0037] This embodiment provides a compound immunopotentiator for tumor treatment, including imiquimod suspension containing imiquimod, OX40 solution containing OX40 agonistic antibody and sodium octanoate solution as an auxiliary material; wherein, imiquimod The special suspension also includes Tween 80 solution and Montanide ISA51. Tween 80 solution is prepared by dissolving Tween 80 in normal saline and pure water; OX40 solution is prepared by dissolving OX40 agonistic antibody in normal saline. The OX40 agonistic antibody in the examples was purchased from Innovent Company, Cat. No. IBI101. OX40 agonistic antibody has T cell co-stimulatory function. Sodium octanoate solution has the effect of promoting the diffusion of reagents in tumor tissue.

[0038] The preparation method of composite immune enhancer comprises the following steps:

[0039] Step 1, the preparation of ...

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PUM

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Abstract

The invention discloses a composite immunopotentiator as well as a preparation method and application thereof. The composite immunopotentiator comprises an imiquimod suspension and an OX40 solution, the imiquimod suspension comprises imiquimod; and the OX40 solution comprises an OX40 agonistic antibody. The composite immunopotentiator further comprises an auxiliary material which is a sodium caprylate solution. The imiquimod suspension also comprises a Tween 80 solution and a Montanide ISA51, The Tween 80 solution is prepared by dissolving Tween 80 in normal saline and pure water. The OX40 solution is prepared by dissolving an OX40 agonistic antibody in normal saline. The composite immunopotentiator can be used for tumor treatment, on one hand, the activity of T cells can be enhanced, on the other hand, a large number of antigens can be provided for tumors, and immune escape is reduced to the maximum extent.

Description

technical field [0001] The invention belongs to the field of medicine and relates to an immune enhancer, in particular to a composite immune enhancer and its preparation method and application. Background technique [0002] Immunotherapy has become one of the most dramatic developments in modern oncology. Based on the immunogenicity of tumors, researchers have used the specificity of the immune system to treat tumors through various channels in the past two decades. T cells play an important role in anti-cancer immune defense, and their activation is regulated by co-stimulatory receptors (activating receptors) and immune checkpoints (inhibitory receptors). Antibodies that block inhibitory receptors, such as CTLA-4 antibodies, PD-1 / PD-L1 antibodies, etc., have made breakthroughs in the past 25 years. [0003] However, agonistic antibodies against co-stimulatory receptors (such as OX40, etc.) have not been able to achieve good curative effect in early trials. In a phase Ib ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395A61K9/10A61K9/08A61K47/12A61K47/26A61K47/44A61P35/00A61P37/04A61K31/437
CPCA61K31/437A61K9/10A61K47/26A61K47/44A61K39/395A61K9/08A61K9/0019A61K47/12A61P35/00A61P37/04A61K2300/00
Inventor 刘芹褚雁鸿李茹恬刘宝瑞
Owner NANJING DRUM TOWER HOSPITAL
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