Inspection method for controlling magnesium salt limit in balance salt solution raw material calcium chloride

Abstract

The invention belongs to the technical field of pharmacy, and particularly relates to an inspection method for controlling magnesium salt limit in balance salt solution raw material calcium chloride. The method comprises the following steps: (1) preparing a test solution; (2) preparing a reference substance solution; and (3) carrying out limit inspection: finally comparing the color of the test solution with the color of the reference solution, wherein the color of the test solution is not darker than that of the reference solution. According to the method, a calcium carbonate precipitation method is adopted, calcium salt is removed after calcium salt precipitation treatment, a magnesium salt exclusive color developing agent-Tantan yellow solution is added, the method has good specificity, and the defect that in the prior art, magnesium salt in calcium chloride cannot be independently detected is overcome. The method adopts a colorimetric method, and has the characteristics of simplicity in operation and obvious phenomenon.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to an inspection method for controlling the limit of magnesium salt in calcium chloride, a raw material of balanced salt solution. Background technique [0002] Balanced salt solution is used as an intraocular irrigation agent for intraocular surgery, and should be isotonic with tears, so the osmotic pressure is strictly controlled in order to minimize eye irritation. As the main component of balanced salt solution, magnesium chloride is also the main contributor to osmotic pressure, so the content of magnesium chloride should be strictly controlled. However, the prescription of balanced salt solution (for perfusion) contains a small amount of magnesium chloride, and calcium chloride contains magnesium salts of metal impurities. In the 17th edition, the calcium chloride raw material quality standards only have magnesium salt and alkali metal salt inspection items, and ...

AI Technical Summary

Problems solved by technology

However, the prescription of balanced salt solution (for perfusion) contains a small amount of magnesium chloride, and calcium chloride contains magnesium salts of metal impurities. In the 17th edition, the calcium chloride raw material quality standards only have magnesium salt and alkali metal salt inspection items, and there is no separate control standard for magnesium salt. Therefore, magnesium salt in calcium chloride will affect the magnesium chloride of balanced salt solution (for perfusion) preparation products Assays have a big impact on

Images