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Composite nano-particle for resisting skin photoaging and preparation method of composite nano-particle

A composite nanoparticle, skin photoaging technology, applied in skin care preparations, nanotechnology for materials and surface science, skin diseases, etc., can solve problems such as low bioavailability, poor stability, and low water solubility of THC , to achieve the effects of good condition controllability, stable production process and simple steps

Active Publication Date: 2021-10-22
CHINA-SINGAPORE INT JOINT RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, THC also has various pharmacological activities such as anti-inflammation and promoting wound healing. However, due to the problems of low water solubility, poor stability, and low bioavailability of THC, its development and application are limited to a certain extent.
At present, there is no report on the topical application of THC nano-preparation to treat photoaging, and there is no related report on Zein-HA composite colloidal particles containing THC nanoparticles

Method used

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  • Composite nano-particle for resisting skin photoaging and preparation method of composite nano-particle
  • Composite nano-particle for resisting skin photoaging and preparation method of composite nano-particle
  • Composite nano-particle for resisting skin photoaging and preparation method of composite nano-particle

Examples

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Effect test

Embodiment 1

[0037] A preparation method of composite nanoparticles for anti-skin photoaging, comprising the following steps:

[0038] (1) Accurately weigh 0.2g Zein and 0.01g THC and dissolve in 20ml of ethanol solution whose mass concentration is 68%-72% (preferably 70%);

[0039] (2) Dissolving 0.03g HA in 60ml ultrapure water to obtain an HA solution with a mass volume ratio of 0.04%-0.06% (preferably 0.05%);

[0040] (3) Add the alcohol solution obtained in step (1) to the HA solution obtained in step (2), and stir magnetically for 3 minutes at a rotating speed of 600 rpm / min to obtain a composite nanoparticle colloid of zein-hyaluronic acid loaded tetrahydrocurcumin solution;

[0041] (4) After the mixed solution obtained in step (3) is rotary evaporated and centrifuged, 20mL of composite nanoparticle colloidal solution is obtained;

[0042] (5) Neutralize the colloidal solution obtained in step (4) to pH 7.4 to obtain a Zein-HA-THC composite nanoparticle solution.

[0043] In this ...

Embodiment 2

[0049] A preparation method of composite nanoparticles for anti-skin photoaging, comprising the following steps:

[0050] (1) Accurately weigh 0.2g Zein and 0.01g THC and dissolve in 20ml of ethanol solution with a mass concentration of 70%;

[0051] (2) Dissolving 0.03g HA in 60ml ultrapure water to obtain a HA solution with a mass volume ratio of 0.05%;

[0052] (3) Add the alcohol solution obtained in step (1) to the HA solution obtained in step (2), and stir magnetically for 3 minutes at a rotating speed of 600 rpm / min to obtain a composite nanoparticle colloid of zein-hyaluronic acid loaded tetrahydrocurcumin solution;

[0053] (4) After the mixed solution obtained in step (3) is rotary evaporated and centrifuged, 20mL of composite nanoparticle colloidal solution is obtained;

[0054] This example carries out gradient test to the mass concentration of HA in step (2), mass volume ratio is respectively: 0.050%, 0.083%, obtains the Zein-HA-THC composite nanoparticle 1%Zein...

Embodiment 3

[0058] A preparation method of composite nanoparticles for anti-skin photoaging, comprising the following steps:

[0059] (1) Accurately weigh 0.2g Zein and 0.01g THC and dissolve in 20ml of ethanol solution with a mass concentration of 70%;

[0060] (2) Dissolving 0.03g HA in 60ml ultrapure water to obtain a HA solution with a mass volume ratio of 0.05%;

[0061] (3) Add the alcohol solution obtained in step (1) to the HA solution obtained in step (2), and stir magnetically for 3 minutes at a rotating speed of 600 rpm / min to obtain a composite nanoparticle colloid of zein-hyaluronic acid loaded tetrahydrocurcumin solution;

[0062] (4) After the mixed solution obtained in step (3) is rotary evaporated and centrifuged, 20mL of composite nanoparticle colloidal solution is obtained;

[0063] This example carries out gradient test to the mass concentration of HA in step (2), mass volume ratio is respectively: 0.050%, 0.083%, obtains the Zein-HA-THC composite nanoparticle 1%Zein...

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Abstract

The invention discloses a composite nano-particle for resisting skin photoaging, tetrahydrocurcumin is embedded in a zein and hyaluronic acid composite particle, the nano-particle in which zein and tetrahydrocurcumin are coated with hyaluronic acid is prepared through an anti-solvent technology, the particle size of the nano-particle is smaller than 300 nm, and the molecular weight of hyaluronic acid is 100 kDa; the invention also discloses a preparation method of the composite nanoparticle for resisting skin photoaging. The preparation method comprises the following steps: S1, adding the zein and the tetrahydrocurcumin into an ethanol solution; preparing a hyaluronic acid aqueous solution; S2, mixing the obtained alcoholic solution with a hyaluronic acid solution; and S3, evaporating and centrifuging the obtained mixed solution, and then carrying out post-treatment to obtain composite nanoparticles. The composite nanoparticles can effectively inhibit apoptosis of epidermal cells and inflammatory response of cells, improve hyperkeratinization of skin induced by UVB, and achieve the effect of preventing skin photoaging.

Description

technical field [0001] The invention relates to the technical field of skin photoaging prevention and treatment, in particular to a composite nanoparticle for anti-skin photoaging and a preparation method thereof. Background technique [0002] The main cause of skin aging under the influence of external environmental factors is sun exposure, and the skin aging process caused by ultraviolet rays in sunlight that is different from natural aging is called photoaging. The specific manifestations are rough skin, dryness, sagging, wrinkles, pigmentation, etc. Acute exposure to ultraviolet rays in the sun can lead to sunburn erythema, skin barrier damage and degradation of connective tissue. cancer. With the deterioration of the global environment, the reduction of the ozone layer and the increase of ultraviolet radiation, the phenomenon of photoaging of human skin is becoming more and more serious, and the incidence of skin cancer is increasing year by year. It has become relevan...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K31/12A61K47/36A61K47/42A61P17/16A61P17/18A61K8/11A61K8/35A61K8/64A61K8/73A61P17/10A61P29/00A61Q19/00A61Q19/08B82Y5/00B82Y30/00B82Y40/00
CPCA61K31/12A61K9/5161A61K9/5169A61K9/0014A61K8/35A61K8/735A61K8/64A61K8/11A61P17/18A61P17/16A61P17/10A61P29/00B82Y5/00B82Y30/00B82Y40/00A61Q19/08A61Q19/00A61Q19/004
Inventor 尹寿伟朱静静黄小楠
Owner CHINA-SINGAPORE INT JOINT RES INST
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