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Quercetin iron ion micelle and application thereof in tumor photothermal immunotherapy

An immunotherapy and iron ion technology, applied in the field of anti-tumor drugs, can solve the problems of difficult preparation production and quality control, concerns about the biological safety of preparations, complex preparations, etc., and achieve strong immune memory, good stability, and good biological safety. Effect

Pending Publication Date: 2021-10-19
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the antibodies used in these combined methods are often very expensive and unstable, and this multi-component combination also makes the preparation more complicated. The industrial production and quality control of the preparation are very difficult, and the biological safety of the preparation is also difficult. worthy of concern

Method used

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  • Quercetin iron ion micelle and application thereof in tumor photothermal immunotherapy
  • Quercetin iron ion micelle and application thereof in tumor photothermal immunotherapy
  • Quercetin iron ion micelle and application thereof in tumor photothermal immunotherapy

Examples

Experimental program
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Effect test

Embodiment 1

[0050] The preparation of embodiment 1 quercetin iron ion micelles

[0051] 5mg quercetin, 5mg ferric chloride (FeCl 3 ), 10mg DSPE-PEG2000 were dissolved in 0.5mL absolute ethanol, stirred at room temperature for 15min, and the stirring speed was 10r / min, and the obtained solution was dripped into 25mL pure water under stirring, and continued to stir for 10min (stirring speed was 6r / min ) to obtain quercetin iron ion micelles dispersed in water.

Embodiment 2

[0052] The preparation of embodiment 2 quercetin ferrous ion micelles

[0053] 5 mg quercetin, 5 mg ferrous chloride tetrahydrate (FeCl 2 .4H 2 0), 10mg DSPE-PEG2000 were dissolved in 0.5mL absolute ethanol, stirred at room temperature for 45min, and the stirring speed was 100r / min, then the solution was instilled into 25mL pure water in the stirring, and continued to stir for 10min (stirring speed was 200r / min / min), the quercetin ferrous ion micelles dispersed in water were obtained.

Embodiment 3

[0054] Example 3 Preparation of Micelles Formed by Quercetin Iron Complex and PEG-PLGA

[0055] 5mg quercetin, 5mg ferric chloride (FeCl 3 ), 100mg PEG-PLGA was dissolved in 2mL absolute ethanol, stirred at room temperature for 15min, and the stirring speed was 1000r / min, then the obtained solution was instilled into 25mL pure water under stirring, and continued to stir for 10min (stirring speed was 1000r / min ) to obtain quercetin iron ion micelles dispersed in water.

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Abstract

The invention relates to a photothermal agent for photothermal therapy of tumors. A compound formed by quercetin and iron ions or ferrous ions through coordinate bonds is wrapped in a micelle (QFM) formed by an amphiphilic polymer, and the photothermal agent has a better photothermal effect and can effectively kill tumor cells when being used for photothermal therapy of tumors. Quercetin released from the micelle can reduce expression of programmed death ligand 1 (PD-L1) of tumor cells and remarkably promote lymphocytes to infiltrate into the tumor to kill residual tumor cells, and part of QFM can also target lymph nodes after intratumor injection; the released quercetin can significantly reduce PD-L1 on the surface of the dendritic cell, so that the ability of presenting tumor cell antigen of the dendritic cell is enhanced. After treatment, the number of memory T cells in the spleen of the mouse is obviously increased, so that the organism forms long-term immune memory on tumor cells, and tumor recurrence is effectively prevented.

Description

technical field [0001] The invention belongs to the technical field of antineoplastic drugs, and more specifically relates to a preparation method and application of a quercetin iron ion micelle preparation. Background technique [0002] Compared with traditional chemotherapy, tumor photothermal therapy has the advantages of less systemic side effects and easy control of the treatment site and duration, which brings hope to the treatment of some superficial tumors such as melanoma. However, there are still few photosensitizers currently available, mainly including indocyanine green (ICG), gold nanoparticles, polydopamine, etc. Due to the limitation of light penetration efficiency, it is difficult for the heat generated by light photosensitizers to kill all tumor cells. Therefore, some malignant tumors such as melanoma often relapse after traditional photothermal agent-mediated photothermal therapy. There is an urgent need for a Novel photothermal agents that reduce tumor re...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K31/352A61K9/107A61K47/34A61K47/24A61P35/00
CPCA61K41/0052A61K41/0057A61K31/352A61K9/1075A61K47/34A61K47/24A61P35/00A61K2300/00
Inventor 张凌李林
Owner SICHUAN UNIV
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