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Polypeptide liposome containing fatty acid, and preparation method thereof

A fatty acid and peptide lipid technology, which is applied in the field of fatty acid-containing polypeptide liposomes and its preparation, can solve the problems of liposome drug transport difficulties, destruction of lipid bilayer structure, drug leakage, etc., to improve skin luster, inhibit The effect of shrinking facial muscles and reducing wrinkles

Pending Publication Date: 2021-10-19
ZHEJIANG YIGE ENTERPRISE MANAGEMENT GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The existing anti-aging liposome products developed by a single mechanism, the liposomes are easy to adhere to the inside of the keratinocyte wall, destroy the lipid bilayer structure, and cause drug leakage, so liposomes have difficulties in drug transport, and Anti-aging liposome products can only exert a certain anti-aging effect, and the effect is relatively single and not obvious

Method used

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  • Polypeptide liposome containing fatty acid, and preparation method thereof
  • Polypeptide liposome containing fatty acid, and preparation method thereof
  • Polypeptide liposome containing fatty acid, and preparation method thereof

Examples

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Effect test

Embodiment 1

[0028] A fatty acid-containing polypeptide liposome, including an oil phase and a water phase, the oil phase includes the following raw materials in parts by weight: 2-8 parts of hydrogenated lecithin, 0.05-1 part of palmitic acid, 0.2-0.8 parts of stearic acid, 0.05-1 part of behenic acid and 15-25 parts of caprylic / capric triglyceride; the water phase includes the following raw materials in parts by weight: 0.05-1 part of acetyl hexapeptide-8, 0.05-1 part of acetyl dipeptide- 1 cetyl ester, 0.05-1 part palmitoyl tripeptide-5, 0.05-1 part tetradecylaminobutyryl valinyl amidobutyrate urea trifluoroacetate, 10-30 parts glycerin, 5-15 parts Butanediol and 39.5-43.3 parts of water.

[0029] The PC content of the hydrogenated lecithin is 50-75%.

[0030] The preparation method of its polypeptide liposome comprises the following steps:

[0031] S1. Mix hydrogenated lecithin, palmitic acid, stearic acid, behenic acid, caprylic acid / capric triglyceride, heat to 65-85°C, stir and di...

Embodiment 2

[0035] A fatty acid-containing polypeptide liposome, comprising an oil phase and an aqueous phase, the oil phase comprising the following raw materials in parts by weight: 2 parts of hydrogenated lecithin, 0.05 part of palmitic acid, 0.2 part of stearic acid, 0.05 part of behenic acid and 15 parts of caprylic / capric triglyceride; the water phase includes the following raw materials in parts by weight: 0.05 part of acetyl hexapeptide-8, 0.05 part of acetyl dipeptide-1 cetyl ester, 0.05 part of palmitoyl tripeptide-5, 0.05 parts tetradecylaminobutyryl valinyl amidobutyrate urea trifluoroacetate, 10 parts glycerin, 5 parts butylene glycol and 39.5 parts water.

[0036] The PC content of the hydrogenated lecithin is 50%.

[0037] The preparation method of its polypeptide liposome comprises the following steps:

[0038] S1. Mix hydrogenated lecithin, palmitic acid, stearic acid, behenic acid, caprylic / capric triglyceride, heat to 65°C and stir to dissolve for 2 hours to obtain the...

Embodiment 3

[0042] A fatty acid-containing polypeptide liposome, comprising an oil phase and an aqueous phase, the oil phase comprising the following raw materials in parts by weight: 8 parts of hydrogenated lecithin, 1 part of palmitic acid, 0.8 part of stearic acid, 1 part of behenic acid and 25 parts of caprylic / capric triglyceride; the water phase includes the following raw materials in parts by weight: 1 part of acetyl hexapeptide-8, 1 part of acetyl dipeptide-1 cetyl ester, 1 part of palmitoyl tripeptide-5, 1 part tetradecylaminobutyryl valinyl amidobutyrate urea trifluoroacetate, 30 parts glycerin, 15 parts butylene glycol, and 43.3 parts water.

[0043] The PC content of the hydrogenated lecithin is 60%.

[0044] The preparation method of its polypeptide liposome comprises the following steps:

[0045] S1. Mix hydrogenated lecithin, palmitic acid, stearic acid, behenic acid, and caprylic / capric triglyceride, heat to 85° C., stir and dissolve for 0.5 h, and obtain the oil phase; ...

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Abstract

The invention discloses a polypeptide liposome containing fatty acid, and a preparation method thereof. The polypeptide liposome comprises an oil phase and a water phase, and the oil phase comprises hydrogenated lecithin, palmitic acid, stearic acid, behenic acid and caprylic / capric triglyceride; and the water phase contains, by weight, acetyl hexapeptide-8, acetyl dipeptide-1 cetyl ester, palmitoyl tripeptide-5, tetradecyl aminobutyryl valamido urea butyrate trifluoroacetate, glycerol, butanediol and water. The preparation method of the polypeptide liposome comprises the following steps: mixing, heating and melting the oil-phase raw materials to obtain the oil phase, mixing, heating and melting the water-phase raw materials to obtain the water phase, and then mixing and homogenizing the oil phase and the water phase to obtain the fatty acid-containing polypeptide liposome. The preparation method has the characteristics that the skin infiltration capacity of the liposome is improved, and all-around synergistic interaction is realized.

Description

technical field [0001] The invention relates to a polypeptide liposome, in particular to a fatty acid-containing polypeptide liposome and a preparation method thereof. Background technique [0002] Skin wrinkles are caused by the joint action of endogenous and exogenous factors. Among them, exogenous factors include ultraviolet radiation, smoke and harmful chemicals, etc., and the reactive oxygen species (ROS) generated by their contact with the skin will directly damage the DNA of skin cells and the collagen, elastin or mucopolysaccharide molecules of the extracellular matrix , so that the skin becomes thinner, the basement membrane of the epidermis and dermis is damaged, the number of cells and the number of blood vessels decrease, resulting in the generation of skin wrinkles; Decreased, decreased skin hydration capacity, decreased concentration of proteoglycan and hyaluronic acid in the skin, decreased moisture in the dermis, decreased activity of dermal fibroblasts, and...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K47/12A61K38/08A61P17/00A61P17/16A61P17/18A61K38/05A61K38/06
CPCA61K9/1277A61K9/1272A61K47/12A61K38/08A61K38/05A61K38/06A61P17/00A61P17/16A61P17/18A61K2300/00
Inventor 张大勇毕永贤杜雨涵周浩淼李昊刘金俊朱秀洁
Owner ZHEJIANG YIGE ENTERPRISE MANAGEMENT GRP CO LTD
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