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Soft tissue filling agent and application thereof

A soft tissue and filler technology, applied in the field of biological preparations, can solve problems such as unnatural hand feeling, liquefaction infection, hardening, etc., and achieve the effect of good breast shaping effect, promotion of blood vessel regeneration, and rich sources.

Inactive Publication Date: 2021-10-01
白晋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the early 1880s, breast augmentation has experienced liquid paraffin injection breast augmentation, silicone oil, silicone prosthetic breast implants, etc., but due to its related complications, including contracture, deformation, hardening, leakage, and unnatural hand feeling, etc. Confused seekers and doctors
However, the success or failure of autologous fat injection for breast augmentation is related to the survival rate of fat cells. There are problems such as absorption after fat tissue injection, so multiple operations are often required, and there are complications such as liquefaction infection.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The preparation method of the autologous tissue-based injection of this embodiment comprises:

[0041] Step 1. Preparation of autologous collagen

[0042] The blood is collected from the human body through blood collection. After the first centrifugation, the blood enters the whole blood separator and undergoes a second centrifugation in the whole blood separator. The whole blood is centrifuged into three layers, from top to bottom are the plasma layer and the buffy coat layer. and erythrocyte layer, the plasma layer, buffy coat layer and erythrocyte layer liquid are respectively introduced into different storage units through catheters and stored separately, and an appropriate amount of plasma layer and buffy coat layer liquid is taken out from the storage unit and mixed at a ratio of 1:1, and passed through the chromatography unit Carry out preliminary purification and further purification by diafiltration unit to obtain the desired autologous collagen;

[0043] Step...

Embodiment 2

[0049] A kind of injection based on autologous tissue, its preparation method comprises:

[0050] Step 1. Preparation of autologous collagen

[0051] The blood is collected from the human body through blood collection. After the first centrifugation, the blood enters the whole blood separator and undergoes a second centrifugation in the whole blood separator. The whole blood is centrifuged into three layers, from top to bottom are the plasma layer and the buffy coat layer. and erythrocyte layer, the plasma layer, buffy coat layer and erythrocyte layer liquid are respectively introduced into different storage units through catheters and stored separately, and an appropriate amount of plasma layer and buffy coat layer liquid is taken out from the storage unit and mixed at a ratio of 1:1, and passed through the chromatography unit Carry out preliminary purification and further purification by diafiltration unit to obtain the desired autologous collagen;

[0052] Step 2. Preparat...

Embodiment 3

[0058] A kind of injection based on autologous tissue, its preparation method comprises:

[0059] Step 1. Preparation of autologous collagen

[0060] The blood is collected from the human body through blood collection. After the first centrifugation, the blood enters the whole blood separator and undergoes a second centrifugation in the whole blood separator. The whole blood is centrifuged into three layers, from top to bottom are the plasma layer and the buffy coat layer. and erythrocyte layer, the plasma layer, buffy coat layer and erythrocyte layer liquid are respectively introduced into different storage units through catheters and stored separately, and an appropriate amount of plasma layer and buffy coat layer liquid is taken out from the storage unit and mixed at a ratio of 1:1, and passed through the chromatography unit Carry out preliminary purification and further purification by diafiltration unit to obtain the desired autologous collagen;

[0061] Step 2. Preparat...

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PUM

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Abstract

The invention discloses a soft tissue filling agent. The soft tissue filling agent is prepared from the following raw materials: collagen, adipose-derived stem cells, cell growth factors and a cross-linking agent. The collagen and the adipose-derived stem cells are adopted for mediating transplantation breast augmentation, the adipose-derived stem cells can obviously improve the survival rate of transplanted adipose cells, tissue differentiated from the adipose-derived stem cells is combined with the collagen, cell growth factors for promoting cell growth are used in a matched mode, bad absorption, infection and necrosis of transplanted fat can be further inhibited. Revascularization of transplanted fat tissue is promoted, the survival rate of transplanted fat is increased, and shaping of breasts is facilitated. The invention does not generate foreign matter reaction, is safe and reliable, and has the advantages of convenience in acquisition, rich sources, good filling effect, small trauma and the like.

Description

[0001] This application is a divisional application with an application date of August 27, 2018, an application number of 201810978453.X, and an invention title of "A Preparation Based on Autologous Tissue and Its Application". technical field [0002] The invention relates to the technical field of biological preparations, in particular to a preparation based on autologous tissue and its application. Background technique [0003] Breast augmentation, also known as breast augmentation or breast augmentation, is a surgery that enlarges the volume of the breast, makes it plump and well-proportioned, improves the body shape of women, and restores the unique curves of women by implanting medical materials or transplanting their own tissues. Since the early 1880s, breast augmentation has experienced liquid paraffin injection breast augmentation, silicone oil, silicone prosthetic breast implants, etc., but due to its related complications, including contracture, deformation, harden...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61P15/14A61L27/24A61L27/38A61L27/22A61L27/50A61L27/54A61K35/28A61K38/18A61K38/30
CPCA61K38/1808A61K38/1825A61K38/30A61K38/39A61L27/227A61L27/24A61L27/3834A61L27/3895A61L27/50A61L27/54A61P15/14A61K9/0019A61K35/28A61L2430/40A61L2430/34A61L2400/06A61L2300/414A61L2430/04A61K2300/00C08L89/00
Inventor 白晋
Owner 白晋
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