Application of meflunidone in preparation of medicine for treating acute kidney injury

A technology of acute kidney injury and meflunidone, applied in the field of application of meflunidone in the preparation of drugs for the treatment of acute kidney injury, to achieve the effect of creatinine level protection

Active Publication Date: 2021-10-01
CENT SOUTH UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For a long time, the clinical treatment of AKI has always followed the principle of symptomatic support, waiting for the outcome of the renal disease itself. So far, there is no one that can be used to reduce renal tissue damage or promote renal repair or prevent chronic renal fibrosis in the later stage of AKI. Therapeutic drugs approved for marketing

Method used

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  • Application of meflunidone in preparation of medicine for treating acute kidney injury
  • Application of meflunidone in preparation of medicine for treating acute kidney injury
  • Application of meflunidone in preparation of medicine for treating acute kidney injury

Examples

Experimental program
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Embodiment

[0018] An application of meflunidone in the preparation of medicines for treating acute kidney injury.

[0019] In order to prove the effect of meflunidone in the preparation of drugs for the treatment of acute kidney injury, this example provides the following experiments to observe the curative effect of meflunidone in the treatment of ischemia-reperfusion-induced AKI in mice:

[0020] 1. Experimental method

[0021] The experimental animal model of ischemia-reperfusion-induced AKI was prepared to observe the curative effect of meflunidone on AKI.

[0022] Taking SPF grade C57BL / 6 mice (7-8 weeks old, male, body weight 20-22g) as the experimental subjects, they were divided into 7 groups, namely control group, model group, meflunidone 25mg / kg treatment group, Meflunidone 50mg / kg treatment group, meflunidone 75mg / kg treatment group, meflunidone 100mg / kg treatment group and meflunidone 125mg / kg treatment group. Two days before modeling (D1), meflunidone was given by intragas...

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Abstract

The invention discloses an application of meflunidone in preparation of a medicine for treating acute kidney injury. When meflunidone is applied to ischemia reperfusion induced AKI mice for treatment, renal tubule pathological injuries can be relieved, the renal function can be improved, and the levels of renal function indexes of urea nitrogen and creatinine can be improved. It is shown that the meflunidone has a treatment effect on the AKI, that is, the medicine prepared from the meflunidone is suitable for treating the AKI. The administration dosage of the meflunidone to a human body is 12.8 mg / kg.

Description

technical field [0001] The present invention relates to ZHC-116, 1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridine-2(1H )-ketone (abbreviated as meflunidone) new medical application. Background technique [0002] Acute kidney injury (AKI) is a common clinical syndrome, its occurrence is often accompanied by prolonged hospitalization, and some patients with poor prognosis will further develop into chronic kidney disease. About 13 million people worldwide suffer from AKI every year (85% of patients live in developing countries), and about 1.7 million people die from AKI and its complications. AKI can occur in many clinical disciplines, especially in the ICU with an incidence of more than 50%. In my country, a large-sample multi-center epidemiological survey data showed that according to the diagnostic criteria and extended criteria of KDIGO AKI, the incidence of AKI was 0.99% and 2.03%, while the in-hospital mortality rate was as high as 12.4%...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/496A61P13/12
CPCA61K31/496A61P13/12
Inventor 彭张哲陶立坚胡高云李乾斌孟婕
Owner CENT SOUTH UNIV
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