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Niazoxanide injection as well as preparation method and application

A technology of nitazoxanide and injection, which is applied in the direction of medical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problems of low bioavailability, inconvenience in medication, and low bioavailability and other problems to achieve the effect of overcoming low bioavailability, reducing dosage, and convenient use

Pending Publication Date: 2021-09-24
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the tablet is made by adding excipients into the tablet, the dissolution rate of the drug after oral administration is slow and the bioavailability is low. The particle size of the drug particles in the suspension is generally 0.5-10 μm, which belongs to an unstable coarse dispersion system. Poor stability and low bioavailability
Someone used nanotechnology to prepare NTZ into nanoemulsion (NTZ-NE), and studied its properties, but due to the complex technical requirements of nanoemulsion, there is no commercial product yet
Nitazoxanide injection can overcome the disadvantages of low bioavailability of tablets and suspensions and inconvenient medication for some animals
There is no report on the application of the nitazoxanide injection formulation involved in the present invention in anti-parasitic aspects after retrieval

Method used

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  • Niazoxanide injection as well as preparation method and application
  • Niazoxanide injection as well as preparation method and application
  • Niazoxanide injection as well as preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Nitazoxanide co-solvent selection

[0021] Take by weighing 5 grams of nitazoxanide, add 20, 40 and 60 milliliters of benzyl alcohol, N,N-dimethylacetamide, ethyl acetate and other co-solvents respectively, observe the solubilizing effects of different dosages of co-solvents, the results Show that 60 milliliters of N,N-dimethylacetamide has a better solubilizing effect, and no precipitation occurs (see figure 1 ), while different doses of benzyl alcohol and ethyl acetate have poor solubilizing effects, resulting in poor solubility or precipitation (see figure 2 ).

Embodiment 2

[0023] Stability of Nitazoxanide Injection

[0024] Place the nitazoxanide injection preparation at 4°C and room temperature, observe the discoloration and precipitation of the nitazoxanide injection at intervals of 0, 10, 30, 60, and 90 days, and determine its stability And storage conditions and time. The results showed that 60 days of nitazoxanide injection at room temperature did not appear obvious discoloration, precipitation, etc., but 90 days of nitazoxanide injection at room temperature turned red (see image 3 ).

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Abstract

The invention provides a nitazoxanide injection preparation as well as a preparation method and application. Nitazoxanide is added into N,N-dimethylacetamide to be stirred and dissolved, and the nitazoxanide injection preparation is prepared. The defects that the bioavailability of medicine tablets and suspensions is low, and part of animals inconveniently take medicine are overcome; and the characteristics of reducing the dosage, being convenient to use and the like can be achieved, the nitazoxanide injection preparation has the effect of resisting animal parasites such as protozoa and nematodes, and a new dosage form is provided for clinical medication.

Description

technical field [0001] The invention provides a nitazoxanide injection and a preparation method of a novel preparation of the nitazoxanide injection, which is used for the treatment of animal parasitic diseases and belongs to the technical field of antiparasitic drugs. Background technique [0002] Nitazoxanide (NTZ) is a new broad-spectrum anti-parasite, bacteria, virus, tumor and other drugs, which has the characteristics of broad-spectrum, good curative effect and wide safety range. However, the dosage forms of nitazoxanide currently used clinically are tablets and suspensions, and there are no other dosage forms such as injection dosage forms. Since the tablet is made by adding excipients into the tablet, the dissolution rate of the drug after oral administration is slow and the bioavailability is low. The particle size of the drug particles in the suspension is generally 0.5-10 μm, which belongs to an unstable coarse dispersion system. Poor stability and low bioavailab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/426A61K47/18A61P33/02A61P33/10
CPCA61K31/426A61K9/0019A61K47/18A61K9/08A61P33/10A61P33/02
Inventor 张西臣张清波张楠王瑜刘少雄李建华宫鹏涛李新王晓岑
Owner JILIN UNIV
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