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A kind of nattokinase transdermal absorption agent for external use and preparation method thereof

The technology of a transdermal absorbent and nattokinase is applied in the field of nattokinase external transdermal absorbent and its preparation, and can solve the problems of poor nattokinase penetration, low bioavailability, poor stability, etc. The effect of poor skin, good absorption and strong stability

Active Publication Date: 2022-05-31
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides an external transdermal absorbent for nattokinase, which has good absorbability and strong stability, solves the problem of poor transdermal properties of nattokinase, and overcomes the low and stable bioavailability of nattokinase when it is taken as an oral preparation sex problem

Method used

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  • A kind of nattokinase transdermal absorption agent for external use and preparation method thereof
  • A kind of nattokinase transdermal absorption agent for external use and preparation method thereof
  • A kind of nattokinase transdermal absorption agent for external use and preparation method thereof

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Embodiment 1

[0052] The transmission electron microscope image of the nattokinase molecular microcapsules is as shown in Figure 1. Figure 2 shows the particle size of nattokinase molecular microcapsules

[0065]

Embodiment 2

[0069]

[0072]

[0073]

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Abstract

The invention discloses a nattokinase transdermal absorbent for external use and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. The nattokinase transdermal absorbent for external use of the present invention is to add the nattokinase molecular microcapsules into the blank matrix by the method of equal addition, make it evenly dispersed, then add humectant, emulsifier, penetration enhancer, stir Evenly, add a pH regulator to adjust the pH value to 6‑7. The nattokinase transdermal absorbent for external use provided by the invention can avoid the low bioavailability and liver first-pass effect caused by oral administration, has the characteristics of good absorption and strong stability, and overcomes the difficulty of nattokinase due to its large molecular weight. The disadvantage of transdermal absorption has realized the goal of external application of nattokinase in treating cardiovascular and cerebrovascular diseases.

Description

A kind of nattokinase external use transdermal absorber and preparation method thereof technical field The invention belongs to the technical field of medicine preparation, be specifically related to a kind of nattokinase external transdermal absorption agent and preparation thereof method. Background technique The data shows that the overall prevalence of dyslipidemia in Chinese adults is as high as 40.4%, and lipid-lowering drug packs are commonly used in clinical practice at present. Including statins, vitamin B3, fibrates, bile acid chelators, polyene fatty acids, etc. Among them, statins are the most commonly used Its lipid-lowering effect is good, but long-term high-dose use will lead to dose-dependence, headache, gastrointestinal symptoms, etc. and muscle adverse reactions (myositis, rhabdomyolysis) and other side effects, and these lipid-lowering drugs are mostly administered orally or intravenously Intravenous administration and application methods have no...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K47/38A61K47/18A61K47/32A61K38/48A61K9/50A61K47/24A61P3/06
CPCA61K38/482C12Y304/21062A61K9/7053A61K47/38A61K47/183A61K9/5015A61P3/06
Inventor 金青刘兴华李微微陈永根郝小惠赵文英谭心舜彭佳
Owner QINGDAO UNIV OF SCI & TECH
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