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Ultraviolet light blocking hydrogel containing immobilized nanoparticles and preparation method thereof

A nanoparticle and hydrogel technology, which is applied in the field of ultraviolet light blocking hydrogel and its preparation, can solve the problems of phase separation, agglomeration, and biological toxicity, and achieve the solution of overflow and agglomeration, mild reaction conditions, and controlled reaction degree of effect

Active Publication Date: 2022-07-12
汉中市硕邦医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In long-term use, there will be problems of overflow, phase separation and agglomeration
In addition, the preparation methods and defects of hydrogels with the function of encapsulating nanoparticles to achieve drug release are basically the same, which not only affects the transparency of hydrogels, but also leads to biological toxicity.

Method used

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  • Ultraviolet light blocking hydrogel containing immobilized nanoparticles and preparation method thereof
  • Ultraviolet light blocking hydrogel containing immobilized nanoparticles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Step 1: Add 50ml of water and ethylene glycol mixed solvent with a volume ratio of 3:1 into the beaker, and add 30g of hydroxyethyl methacrylate and ethylene glycol dimethacrylate with a mass ratio of 1:0.05:0.015 And 1-allylpiperazine mixture, ultrasonically dispersed for 15min at low temperature, then add 0.1g azobisisobutyronitrile and ultrasonically divided at low temperature for 45min, after ultrasonic dispersion is completed, pour into the mold, stand at 40 ° C for 9h , heated to 60°C and kept for 12h to obtain an intermediate product;

[0029] Step 2: Put the intermediate product obtained in step 1 into a three-necked flask, add 200ml of deionized water to soak for 2 days, replace the deionized water every 8h during the period, and then pass nitrogen for 30min, and then move the whole system into a shaking shaker, Adjust the shaking speed to 200rpm / min, first add 60mlm of sodium borohydride solution with a concentration of 0.3g / ml, then dropwise add 55ml of ferri...

Embodiment 2

[0033] Step 1: Add 60ml of water and ethylene glycol mixed solvent with a volume ratio of 3:1 into the beaker, and add 30g of hydroxyethyl methacrylate and ethylene glycol dimethacrylate with a mass ratio of 1:0.05:0.05 and N-ethylmethacrylamine mixture, ultrasonically dispersed at low temperature for 25min, then added 0.07g azobisisobutyronitrile and ultrasonically dispersed at low temperature for 40min. After ultrasonic dispersion was completed, poured into the mold and stood at 50°C for 10h Then, the temperature was raised to 60 °C and kept for 24 h to obtain an intermediate product;

[0034] Step 2: Put the intermediate product obtained in step 1 into a three-necked flask, add 200ml of deionized water to soak for 3 days, replace the deionized water every 8h during the period, and then pass nitrogen for 50min, and then move the whole system into a shaking shaker, Adjust the shaking speed to 200rpm / min, first add 100ml of sodium borohydride solution with a concentration of 0...

Embodiment 3

[0038] Step 1: Add 65ml of water and ethylene glycol mixed solvent with a volume ratio of 4:1 into the beaker, and add 45g of hydroxyethyl methacrylate and ethylene glycol dimethacrylate with a mass ratio of 1:0.05:0.015 And 1-allylpiperazine mixture, ultrasonically dispersed for 30min at low temperature, then add 0.8g azobisisobutyronitrile and ultrasonically dispersed at low temperature for 50min, after ultrasonic dispersion is completed, pour into the mold, stand at 55 ℃ for 18h , heated to 80°C and kept for 30h to obtain an intermediate product;

[0039] Step 2: Put the intermediate product obtained in step 1 into a three-necked flask, add 300ml of deionized water for 2 days, replace the deionized water every 8h during the period, and then pass nitrogen for 50min, and then move the whole system into a shaking shaker, Adjust the shaking speed to 250rpm / min, first add 125ml of sodium borohydride solution with a concentration of 0.3g / ml, then dropwise add 95ml of ferric chlor...

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Abstract

The invention belongs to the technical field of functional hydrogel materials, and discloses an ultraviolet light blocking hydrogel containing immobilized nanoparticles and a preparation method thereof. Using the oxidation-reduction initiator of nano-iron oxide formed by the oxidation of zero-valent iron particles and persulfate to initiate microemulsion polymerization of monomers with UV light blocking function and carboxyl group-containing monomers in hydrogels to form microemulsion polymerization with UV light blocking Nanoparticles with high performance, and then use EDC / NHS to achieve the immobilization of nanoparticles in hydrogels. The invention utilizes zero-valent nano-iron particles to slowly provide Fe after oxidation 2+ As a sustained release agent and persulfate to form a redox system, it ensures that the nanoparticles with light blocking effect are formed in the hydrogel under relatively mild conditions, and the next curing conditions are also relatively mild and difficult to damage the hydrogel structure. The invention fixes the nanoparticles with ultraviolet light blocking performance in the hydrogel system through EDC / NHS, and solves the problems of overflow and agglomeration of the nanoparticles after long-term use.

Description

Technical field: [0001] The invention belongs to the technical field of functional hydrogel materials, in particular to an ultraviolet light blocking hydrogel containing immobilized nanoparticles and a preparation method thereof. Background technique: [0002] Polymer hydrogels can be used in corneal contact angle, artificial tissue and other fields. When it is applied to corneal contact lenses, hydrogels with light-blocking ultraviolet light and drug-releasing functions have more promotion value and application prospects, but the traditional light-blocking hydrogels are made of small molecules or inorganic nanoparticles. The light blocking agent is added to the hydrogel raw material by physical blending, and the raw material remains in the hydrogel after the reaction. In long-term use, there will be problems of overflow, phase separation and agglomeration. In addition, the preparation method and defects of the hydrogel with the drug release function by encapsulating nanop...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L51/00C08K3/22C08F265/06C08F220/18C08F220/26C08F220/36C08F220/20C08F222/14C08F226/06C08F226/02
CPCC08J3/075C08F265/06C08F220/20C08J2351/00C08K2003/2265C08K2201/011C08F220/1804C08F220/26C08F220/36C08F222/102C08F226/06C08F226/02
Inventor 张玲于健兰巧巧毛小雨
Owner 汉中市硕邦医疗科技有限公司
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