Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Levofloxacin hydrochloride tablet and preparation method thereof

A levofloxacin hydrochloride tablet, selected from the technology, applied in the direction of medical formula, non-active ingredient medical preparations, medical preparations containing active ingredients, etc., can solve the problem of levofloxacin hydrochloride dosage form is not easy to preserve, easy to deteriorate, etc., to achieve superior stability High reliability, high yield and good repeatability

Inactive Publication Date: 2021-09-17
HAINAN HAISHEN TONGZHOU PHARM CO LTD
View PDF6 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Existing formulations of levofloxacin hydrochloride are not easy to preserve and are prone to deterioration

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Levofloxacin hydrochloride tablet and preparation method thereof
  • Levofloxacin hydrochloride tablet and preparation method thereof
  • Levofloxacin hydrochloride tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0051] Secondly, the present invention provides the preparation method of the levofloxacin hydrochloride tablet described in any one of the above technical solutions, specifically, comprising the following steps:

[0052] (1) mixing the levofloxacin hydrochloride, the diluent and the hydroxypropyl cellulose to obtain raw materials;

[0053] (2) adding the adhesive to the raw and auxiliary materials obtained in step (1), and granulating;

[0054] (3) drying the granules prepared in step (2) to obtain dry granules;

[0055] (4) add described lubricant and described carboxymethyl starch sodium in the dry grain that step (3) obtains, granulate;

[0056] (5) Compressing and coating the granules obtained in step (4).

[0057] The preparation method of levofloxacin hydrochloride tablet of the present invention, as preferred embodiment, in described step (5), the step of described coating comprises:

[0058] Preheat the plain tablet after tableting to 35-45°C, the speed of the coat...

Embodiment 1

[0071] The present embodiment provides a kind of levofloxacin hydrochloride tablet and preparation method thereof, and following formula is the formula of 100:

[0072] Drug Prescription:

[0073]

[0074]

[0075] Coating powder:

[0076] Gastric-soluble coating powder 0.6g

[0077] 70% ethanol 8.5mL.

[0078] The preparation method is:

[0079] 1) Levofloxacin hydrochloride is passed through an 80-mesh sieve; starch, dextrin, hydroxypropyl cellulose and sodium carboxymethyl starch are respectively passed through an 80-mesh sieve.

[0080] 2) Mix levofloxacin hydrochloride, starch, dextrin and hydroxypropyl cellulose evenly.

[0081] 3) Add 5% starch for pulp to the homogeneously mixed raw and auxiliary materials, and granulate with a 20-mesh sieve.

[0082] 4) drying the prepared wet granules at 60° C. to obtain dry granules.

[0083] 5) Magnesium stearate and sodium carboxymethyl starch are added to the dry granules, mixed evenly, and granulated with a 18-mesh s...

Embodiment 2

[0089] The present embodiment provides a kind of levofloxacin hydrochloride tablet and preparation method thereof, and following formula is the formula of 100:

[0090] Drug Prescription:

[0091]

[0092] Coating powder:

[0093] Gastric-soluble coating powder 0.6g

[0094] 70% ethanol 8.5mL.

[0095] The preparation method is:

[0096] 1) Levofloxacin hydrochloride is passed through an 80-mesh sieve; starch, dextrin, and sodium carboxymethyl starch are respectively passed through an 80-mesh sieve.

[0097] 2) Mix levofloxacin hydrochloride, starch and dextrin evenly.

[0098] 3) Add 5% starch for pulp to the homogeneously mixed raw and auxiliary materials, and granulate with a 20-mesh sieve.

[0099] 4) drying the prepared wet granules at 60° C. to obtain dry granules.

[0100] 5) Magnesium stearate and sodium carboxymethyl starch are added to the dry granules, mixed evenly, and granulated with a 18-mesh sieve.

[0101] 6) Punching and die pressing of φ8mm.

[010...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a levofloxacin hydrochloride tablet and a preparation method thereof. The levofloxacin hydrochloride tablet is prepared from the following components in parts by weight: 80-150 parts of levofloxacin hydrochloride, 50-80 parts of a diluent, 5-20 parts of a disintegrating agent, 1-5 parts of a lubricant and 5-10 parts of an adhesive. The levofloxacin hydrochloride tablet is simple in preparation process, good in repeatability and high in yield, and the prepared product is smooth in appearance and has excellent stability.

Description

technical field [0001] The invention relates to the field of medicine production, in particular to a levofloxacin hydrochloride tablet and a preparation method thereof. Background technique [0002] Levofloxacin hydrochloride is a quinolone antibiotic, which acts on bacterial DNA gyrase (topoisomerase II), inhibits the activity of DNA gyrase to hinder DNA replication, and kills bacteria. It has been used clinically to treat respiratory tract infections, gynecological infections, intestinal infections, etc. and has achieved good results. Because of its advantages of high curative effect, mild adverse reactions, small bacterial resistance, and safe and convenient medication, it is a potential broad-spectrum antibacterial drug for treating various infections. [0003] The existing formulations of levofloxacin hydrochloride are not easy to preserve and are prone to deterioration. Contents of the invention [0004] The present invention firstly provides a levofloxacin hydroch...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/20A61K9/28A61K47/36A61K47/38A61K47/12A61K31/5383A61P31/04
CPCA61K9/2095A61K9/2059A61K9/2054A61K9/2013A61K9/2806A61K31/5383A61P31/04
Inventor 刘玉韦家华
Owner HAINAN HAISHEN TONGZHOU PHARM CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com