Application of pazopanib, pharmaceutical composition, injection, preparation method and application
A technology of pazopanib and its composition, applied in the fields of application, pharmaceutical composition, injection and preparation and application of pazopanib, capable of solving the problems of no introduction of acute lung injury, no acute lung injury, etc.
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Embodiment 1
[0065] Embodiment 1 pharmaceutical composition and preparation method thereof
[0066] 1. Taking the pharmaceutical composition as 1 mL; the concentration of pazopanib hydrochloride in the pharmaceutical composition is 5 mg / mL, and the concentration of hydroxypropyl-β-cyclodextrin in the pharmaceutical composition is 200 mg / mL; the concentration of the pharmaceutical composition The pH is 3.25.
[0067] 2. The preparation method of the above-mentioned pharmaceutical composition specifically comprises the following steps:
[0068] (1) Pour 5 mg of pazopanib hydrochloride into a container containing 1 mL of 200 mg / mL hydroxypropyl-β-cyclodextrin solution, the solvent in the hydroxypropyl-β-cyclodextrin solution For injection water. The concentration of pazopanib hydrochloride in the mixed solution is 5 mg / mL, and the concentration of hydroxypropyl-β-cyclodextrin is 200 mg / mL; among them, the water for injection needs to be filled with nitrogen for 30 minutes before use;
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