Pandanus tectorius(L.)Parkins extract and application thereof in preparation of medicine for treating hyperuricemia

A technology of hyperuricemia and wild pineapple, applied in the field of traditional Chinese medicine, can solve the problems of patients suffering from taking medicine, easy recurrence of gout, and low acceptance

Pending Publication Date: 2021-09-03
浙江黛君生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] At the same time, there are many traditional Chinese medicine prescriptions for treating gout. For example, traditional Chinese medicines that clear away heat and wind, dredge collaterals and promote dampness, or traditional Chinese medicines that clear heat and diuresis, relieve stranguria and expel stones are generally used for gout prevention and treatment. Jincao, Daxueteng, etc., these medicines are often of great cold, great poison, and have certain side effects, and the therapeutic effect of various prescriptions is not significant
Moreover, the above-mentioned traditional Chinese medicines are all prepared by traditional pharmaceutical methods. In addition, the source of medicinal materials is disordered, so that the onset of traditional Chinese medicine gout preparations is slow, the clinical medication period is long, the patients are painful to take the medicine, and the acceptance is low. Drug Preparation Technology
In addition, the current clinical treatment of gout is prone to recurrence, which requires strict control of diet and irregular medication, and the development of drugs that can completely relieve the symptoms of gout
[0007] Therefore, research and development of a drug for the treatment of hyperuricemia with short course of treatment, quick onset, high clinical cure rate, and not easy to relapse, all of which are made from mild Chinese herbal raw materials, can relieve the pain caused by the existing traditional Chinese medicine preparations for the treatment of hyperuricemia. It often contains great cold, and the side effects caused by big poisonous drugs have become very necessary and urgent

Method used

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Examples

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Effect test

preparation example Construction

[0049] The preparation method of the wild pineapple extract is as follows: first, wild pineapple fresh fruit is pretreated to obtain wild pineapple powder; then, the wild pineapple powder is subjected to water extraction to obtain a water extract and a water extraction filter residue; then, the water extraction filter residue is subjected to alcohol extraction , to obtain the alcohol extract; finally, the water extract and the alcohol extract are mixed to obtain the wild pineapple extract.

[0050] The wild pineapple extract provided by the present invention, the wild pineapple extract is mainly obtained by successively concentrating and spray-drying the wild pineapple extract; wherein, the preparation method of the wild pineapple extract is: firstly pre-preparing the wild pineapple fresh fruit processing to obtain wild pineapple powder; then carrying out water extraction of wild pineapple powder to obtain water extract and water extraction filter residue; then carrying out alc...

Embodiment 1

[0084] A kind of medicine for the treatment of hyperuricemia, the preparation method of described medicine comprises the following steps:

[0085] (1), the mature wild pineapple fruit is picked, cleaned, and the soft pulp is cut off, put into a 60°C blast drying oven for drying, and the hard seeds are partly dried in a ventilated place; the pulp and seeds are mixed, and pulverized with a pulverizer to pass through a 60-mesh sieve powder;

[0086] (2) Weigh wild pineapple powder, add 3 times the volume of pure water, extract at 80°C for 1 hour, filter through a 200-mesh filter cloth, add 3 times the volume of 80% ethanol to the filter residue, extract at 60°C for 1 hour, and extract 2 times in total; combine the above The extract is concentrated by a vacuum rotary evaporator at 50°C to a content content of about 80%; then, the concentrate is spray-dried to obtain wild pineapple extract;

[0087] The inlet temperature of the spray drying is 130°C, and the outlet temperature is ...

Embodiment 2

[0095] A kind of medicine for the treatment of hyperuricemia, the preparation method of described medicine comprises the following steps:

[0096] (1), the mature wild pineapple fruit is picked, cleaned, and the soft pulp is cut off, put into a 60°C blast drying oven for drying, and the hard seeds are partly dried in a ventilated place; the pulp and seeds are mixed, and pulverized with a pulverizer to pass through a 60-mesh sieve powder;

[0097] (2) Weigh wild pineapple powder, add 10 times the volume of pure water, extract at 80°C for 1 hour, filter with a 200-mesh filter cloth, add 10 times the volume of 80% ethanol to the filter residue, extract at 60°C for 1 hour, and extract twice in total; combine the above The extract is concentrated by a vacuum rotary evaporator at 50°C to a content content of about 80%; then, the concentrate is spray-dried to obtain wild pineapple extract;

[0098] The inlet temperature of the spray drying is 180°C, and the outlet temperature is 85°...

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Abstract

The invention provides Pandanus tectorius(L.)Parkins extract and application thereof in preparation of a medicine for treating hyperuricemia, and relates to the technical field of traditional Chinese medicines. The Pandanus tectorius(L.)Parkins extract is mainly prepared from a Pandanus tectorius(L.)Parkins extracting solution through concentration and spray drying in sequence; wherein a preparation method of the Pandanus tectorius(L.)Parkins extracting solution comprises the following steps: firstly, pretreating fresh fruits of Pandanus tectorius(L.)Parkins to obtain Pandanus tectorius(L.)Parkins fruit powder; then, subjecting the Pandanus tectorius(L.)Parkins fruit powder to water extraction, thereby obtaining water extract and water extraction filter residues; then carrying out alcohol extraction on the water extraction filter residues to obtain alcohol extracting solution; and finally, uniformly mixing the water extract and the alcohol extract to obtain the Pandanus tectorius(L.)Parkins extracting solution. The Pandanus tectorius(L.)Parkins extract prepared by the method disclosed by the invention has a very good treatment effect on hyperuricemia, and the medicine for treating hyperuricemia prepared from the Pandanus tectorius(L.)Parkins extract can effectively relieve the problem of medicine side effects caused by the fact that a traditional Chinese medicine preparation for treating hyperuricemia often contains severe cold and toxic medicines in the prior art.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a wild pineapple extract and its application in the preparation of medicines for treating hyperuricemia. Background technique [0002] Gout is an inflammatory disease induced by monosodium urate crystals. Long-term active purine metabolism, excessive intake of purine, or impaired uric acid excretion can all lead to hyperuricemia (HUA). Long-term hyperuricemia can cause urate crystal deposition in joints and surrounding soft tissues, followed by recurrent acute joint and soft tissue inflammation, tophi deposition, chronic arthritis and joint damage. At present, there is no effective cure for gout and hyperuricemia clinically. Hyperacidemia has become the second largest metabolic disease after diabetes, especially in economically developed cities and coastal areas. HUA in economically developed areas of my country The prevalence rate of the disease has reached ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/88A61K36/8905A61P19/06A23L33/105A23L33/10A61K35/24A61K35/62
CPCA61K36/88A61K36/236A61K36/284A61K36/736A61K36/286A61K36/54A61K36/484A61K36/328A61K36/232A61K35/24A61K36/8905A61K36/21A61K35/62A61K36/40A61K36/268A61K36/238A61P19/06A23L33/105A23L33/10A61K2236/331A61K2236/333A61K2236/51A61K2236/39A23V2002/00A61K2300/00A23V2200/30A23V2250/21A23V2250/204
Inventor 王代军王帆林
Owner 浙江黛君生物医药科技有限公司
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