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Three-dimensional scaffold with controllable internal surface, and preparation method thereof

A three-dimensional stent, internal surface technology, used in medical science, surgery, additive processing, etc., to achieve the effect of easy operation, wide material applicability, and high precision

Inactive Publication Date: 2021-08-27
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether it is traditional scaffold preparation or rapid prototyping technology, the current scaffold preparation technology is still a great challenge to prepare controllable micro-topography on the inner surface of the scaffold.

Method used

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  • Three-dimensional scaffold with controllable internal surface, and preparation method thereof
  • Three-dimensional scaffold with controllable internal surface, and preparation method thereof
  • Three-dimensional scaffold with controllable internal surface, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] (1) Build as figure 1 The three-dimensional internal surface microtopography support model shown (when building the three-dimensional support model, the software SolidWorks 2017 was used to construct), and the support model was segmented into slices of 0.25mm (the segmentation figure is as follows figure 2 ), the two-dimensional sheet model is obtained, and its structure is as follows image 3 Shown in the middle layer;

[0048](2) Use a 3D printer to print polycaprolactone (PCL) wires according to the two-dimensional sheet model and its data, and prepare 3-10 two-dimensional sheet materials of this structure; wherein, the printing temperature is 80°C, The printing speed is 4mm / s, and the thickness of the two-dimensional scaffold sheet material is 0.25mm;

[0049] (3) Construct a pit-like pattern model with a size of 30×30 μm and an interval of 10 μm (when constructing a micro-pattern model, use the software CorelDrawX8 to construct it), and use a photolithography ma...

Embodiment 2

[0058] (1) Build as figure 1 The three-dimensional internal surface microtopography support model shown (when constructing the three-dimensional support model, the software SolidWorks 2017 is used to construct), and the support model is divided into 0.25mm slices to obtain a two-dimensional slice model;

[0059] (2) Use a 3D printer to print polycaprolactone (PCL) wires according to the two-dimensional sheet model and its data, and prepare 3-10 two-dimensional sheet materials of this structure; wherein, the printing temperature is 80°C, The printing speed is 4mm / s, and the thickness of the two-dimensional scaffold sheet material is 0.25mm;

[0060] (3) Construct a micro-groove pattern model with a size of 2 cm × 40 μm and an interval of 10 μm (when constructing a micro-pattern model, use the software CorelDrawX8 to construct it), and use a photolithography machine to make SU-8 photoresist on a silicon wafer Obtain the required micro-pattern through processes such as gluing, g...

Embodiment 3

[0066] (1) Build as Figure 12 The three-dimensional internal microtopography + poly(hydroxyethyl methacrylate) hydrophilic layer alternating scaffold model shown (when constructing the three-dimensional scaffold model, the software SolidWorks 2017 was used to construct it), and the scaffold model was segmented into slices of 0.25mm , to obtain a two-dimensional sheet model,

[0067] (2) Use a 3D printer to print polycaprolactone (PCL) wires according to the two-dimensional sheet model and its data, and prepare 3-10 two-dimensional sheet materials of this structure; wherein, the printing temperature is 80°C, The printing speed is 4mm / s, and the thickness of the two-dimensional scaffold sheet material is 0.25mm;

[0068] (3) Construct a pit-shaped pattern model with a size of 30 μm×30 μm and an interval of 10 μm (when constructing a micropattern model, use the software CorelDraw X8 to construct it), and use a photolithography machine to make SU-8 photoresist on silicon On the...

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Abstract

The invention belongs to the technical field of tissue engineering scaffolds, and discloses a three-dimensional scaffold and a preparation method thereof. The micro topological morphology and chemical structure of the internal surface of the scaffold are controllable. The method comprises the following steps: (1) printing a two-dimensional lamella material segmented according to a three-dimensional scaffold model; (2) constructing a micropattern on the surface of the two-dimensional lamella; (3) carrying out chemical modification on the surface of the two-dimensional lamella; (4) stacking and bonding the two-dimensional lamella materials in step (2), step (3) or the step (2) and the step (3); and (5) obtaining the three-dimensional scaffold with the controllable micro-morphology chemical structure on the internal surface. The method disclosed by the invention is simple in process and convenient to operate, and the scaffold with the controllable surface chemical structure and the controllable surface topological structure can be obtained.

Description

technical field [0001] The invention belongs to the field of tissue engineering scaffolds, in particular to a three-dimensional scaffold with a controllable inner surface and a preparation method thereof. Background technique [0002] Surface microtopography is the characteristic of simulating the cell microenvironment in vivo to induce cell growth, arrangement and stimulation. When the tissue is damaged by external factors, the specific microtopography of the material surface can promote the arrangement of tissue cells in a specific way. , Migration and differentiation, so as to promote the repair and healing of damaged tissues in an orderly combination of cells, so that the tissues can reduce the influence of abnormal function after tissue repair caused by cell disorder. The surface microtopography preparation technology of materials is to produce miniaturized patterns with a size ranging from nanometers to micrometers and a certain functional structure according to people...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/06A61L31/04A61L31/02A61L31/14A61L31/16B33Y10/00B33Y70/10B33Y80/00
CPCA61L31/06A61L31/048A61L31/028A61L31/047A61L31/14A61L31/16B33Y10/00B33Y70/10B33Y80/00C08L67/04C08L33/14C08L89/00
Inventor 吴刚蔡夏雨高会场
Owner SOUTH CHINA UNIV OF TECH
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