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Preparation method of functional coating material for biological tissue scaffold or catheter

A biological tissue and functional technology, applied in the direction of catheters, coatings, prostheses, etc., can solve the problems of unsustainable effect, poor effect, obvious defects, etc., to reduce the probability of intimal hyperplasia, simple operation process, inhibition The effect of smooth muscle cell proliferation

Active Publication Date: 2022-07-22
JIAXING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But simply mixing the drug in the coating, the effect cannot last long, the defect is obvious, and the effect is still not good

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The preparation method of the functional coating material for the biological tissue scaffold, the specific steps are as follows:

[0036] (1) The mass ratio of PEG-bis(4-nitrophenyl) carbonate (the number-average molecular weight Mn of PEG is 800) and the chitosan (the weight-average molecular weight Mw is 50,000, the degree of deacetylation is 0.7:1) 85%) in an acetic acid solution with a concentration of 1.5% (v / v), and then freeze-drying and washing with ethanol to remove impurities to obtain PEG-grafted chitosan; wherein, the concentration of chitosan after being dissolved in the acetic acid solution is 1.0wt%;

[0037] The PEG grafting degree of the prepared PEG-grafted chitosan is 5%;

[0038] (2) After dissolving the PEG-grafted chitosan in the acetic acid solution with a concentration of 20% (v / v), adding a NaOH solution with a concentration of 3 mol / L to adjust the pH to 6, and then adding heparin sodium and FGF to obtain a mixed solution , and stirred for 1 ...

Embodiment 2

[0056] The preparation method of the functional coating material for the biological tissue scaffold, the specific steps are as follows:

[0057] (1) The mass ratio of PEG-bis(4-nitrophenyl) carbonate (the number-average molecular weight Mn of PEG is 1000) and chitosan (the weight-average molecular weight Mw is 80,000, the degree of deacetylation is 1:1) 90%) in the acetic acid solution with a concentration of 1.8% (v / v), and then freeze-drying and washing with ethanol to remove impurities to obtain PEG-grafted chitosan; wherein, the concentration of chitosan after being dissolved in the acetic acid solution is 2wt%;

[0058] The PEG grafting degree of the prepared PEG-grafted chitosan is 7%;

[0059] (2) After dissolving PEG-grafted chitosan in acetic acid solution with a concentration of 20% (v / v), adding NaOH solution with a concentration of 3 mol / L to adjust the pH to 6, and then adding tanshinone IIA sodium sulfonate and VEGF The mixed solution was obtained, and the func...

Embodiment 3

[0064] The preparation method of the functional coating material for catheter, the specific steps are as follows:

[0065] (1) The mass ratio of PEG-bis(4-nitrophenyl) carbonate (the number-average molecular weight Mn of PEG is 1500) and chitosan (the weight-average molecular weight Mw is 50,000, the degree of deacetylation is 1.4:1) 90%) in an acetic acid solution with a concentration of 1.9% (v / v), and then freeze-drying and washing with ethanol to remove impurities to obtain PEG-grafted chitosan; wherein, the concentration of chitosan after being dissolved in the acetic acid solution is 2.3wt%;

[0066] The PEG grafting degree of the prepared PEG-grafted chitosan is 10%;

[0067] (2) After dissolving the PEG-grafted chitosan in the acetic acid solution with a concentration of 20% (v / v), adding a NaOH solution with a concentration of 3 mol / L to adjust the pH to 6, and then adding tanshinone IIA sodium sulfonate to obtain a mixed solution The solution was stirred for 1.8 ho...

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Abstract

The invention relates to a preparation method of a functional coating material for biological tissue scaffolds or catheters. The preparation method comprises the following steps of: self-assembling PEG-grafted chitosan with one or more functional compounds and growth factors in a solution state The functional composite material solution is obtained, and the functional coating material is obtained by cross-linking treatment after coating the substrate; the substrate is a biological tissue scaffold or a catheter; and the functional compound is a compound with a sulfonic acid group. The functional coating material prepared by the preparation method of the present invention can regulate the antithrombotic performance of the vascular stent, and at the same time, the functional compounds / growth factors can also induce the stem cells, endothelial cells / progenitor cells in the blood to aggregate on the material, accelerate the endothelialization.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a preparation method of a functional coating material for biological tissue stents or catheters. Background technique [0002] At present, vascular transplantation is widely used in the treatment of cardiovascular diseases, including coronary artery bypass grafting, hemodialysis, and diabetic lower extremity vascular disease. At present, large-diameter (diameter ≥ 6 mm) artificial blood vessels made of polyethylene phthalate (PET), expanded polytetrafluoroethylene (ePTFE) and other materials have been widely used in the treatment of aortic diseases. However, small-caliber blood vessels (caliber <6mm) are in a special state of high tension and low blood flow. Small-caliber artificial blood vessels (referred to as vascular stents) made of the above two materials have a high failure rate after transplantation. Manifested as thrombosis and intimal hyperplasia, limiting...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/34A61L27/48A61L27/22A61L27/54A61L29/04A61L29/12A61L29/08C08B37/08
CPCA61L27/34A61L27/54A61L27/227A61L27/48A61L29/085A61L29/126A61L29/048C08B37/003A61L2300/414A61L2300/42A61L2300/606C08L5/08
Inventor 尹岸林樊勇勇李雲环颜志勇詹建朝许志
Owner JIAXING UNIV
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