Multi-dimensional barrier repair composition and preparation method thereof

Abstract

The invention discloses a multi-dimensional barrier repair composition. The composition comprises a functional compound, an osmotic equilibrium agent and a solvent; the functional compound comprises a functional component A which is a component capable of promoting keratinization envelope and tight junction protein expression, a functional component B which is a component capable of improving the self-moisturizing power of the skin, a functional component C which is a component capable of activating a PPAR receptor and strengthening a skin lipid barrier, a functional component D which is a component capable of regulating an immune barrier and relieving skin inflammation, and a functional component E which is a component capable of balancing the microecology of the epidermis; the osmotic equilibrium agent comprises one or more of lecithin and / or hydrogenated lecithin, maintains all the functional components to safely and effectively permeate to different sites of the skin barrier, and is an important component for enabling the composition to play a role; and the solvent comprises deionized water and an organic solvent. The invention also discloses a preparation method of the multi-dimensional barrier repair composition. The multi-dimensional barrier repair composition is capable of realizing effective co-dissolution of the functional compound, the osmotic equilibrium agent and the solvent in the composition.

Description

technical field [0001] The invention relates to a multidimensional barrier repairing composition and a preparation method thereof, belonging to the fields of medicine and cosmetics. Background technique [0002] The skin is the largest organ of the human body, and the skin barrier constitutes the largest protective layer between the human body and the outside world. It can not only reduce the loss of subcutaneous water and active substances, but also effectively alleviate the irritation caused by external factors such as ultraviolet rays and dust particles. [0003] A complete skin barrier usually consists of three major plates from the outside in: the microbial barrier, the physical barrier, and the immune barrier. The microbial barrier is mainly composed of probiotics on the surface of the skin, which form a good skin microecology through normal microbial activities; the physical barrier is commonly referred to as the stratum corneum, and the stratum corneum contains ceram...

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Problems solved by technology

[0006] At present, barrier repair related products on the market are mainly aimed at the following methods: 1: "sandwich" structure repair, through external application of ceramide and cholesterol to fill the skin's missing lipids; 2: using polysaccharides and other moisturizers to relieve skin dryness and dehydration ; 3: A few reports improve the skin's own barrier ability by promoting the secretion of related factors by cells; although the above angles can alleviate the degree of barrier damage to a certain extent, the skin's absorption of exogenous lipids and moisturizers is relatively limited, and at the same time , because the test concentration of the cell experiment is far from the concentration added in the cosmetics, if there is no relevant penetration test to prove it, the reference value of repairing the barrier from the cell level alone will be low

[0007] From the perspective of safe and effective permeability, there is no report on a composition that contains functional ingredients and osmotic balance agents, and can comprehensively repair the skin barrier in multiple dimensions

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