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Long-acting depression relieving microneedle patch and preparation method thereof

A micro-needle patch, depression technology, applied in the directions of micro-needling, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve problems such as affecting the treatment effect, and achieve the enhancement of micro-needle strength and relieve depression symptoms. , The effect of good slow release performance

Pending Publication Date: 2021-08-24
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the clinical use of depressive psychosis, toxic and side effects, large adverse reactions and price factors need to be considered, and the interference of the individual mental state of the patient on self-administered medication needs to be considered. Depressed patients often find it difficult to continue to adhere to the doctor's order and take quantitative medication on time, which affects the therapeutic effect.

Method used

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  • Long-acting depression relieving microneedle patch and preparation method thereof
  • Long-acting depression relieving microneedle patch and preparation method thereof
  • Long-acting depression relieving microneedle patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Preparation of fluoxetine-containing microneedle patch for long-acting relief of depression

[0036] Weigh 50 parts of catechol, 50 parts of sorbic acid, 50 parts of gelatin, 50 parts of dioctyl maleate, 20 parts of polyquaternium, 200 parts of glycerin, and 1000 parts of distilled water, and place them in a constant temperature water bath at 40°C Heat for 30 minutes, add 10 parts of potassium persulfate as hair agent and 25 parts of methylenebisacrylamide as cross-linking agent after completely dissolving, heat up to 60°C while stirring in a constant temperature magnetic stirrer, keep the cross-linking reaction for 1 hour, A colorless and transparent gel-like hydrogel was obtained, which was purified in a 5000mL large beaker for distillation for 2 days, then taken out, and placed in a constant temperature drying oven at 50°C to fully dry to constant weight to obtain a hydrogel bonding layer.

[0037]Weigh 30 parts of calcium carbonate, 50 parts of N-methylpyr...

Embodiment 2

[0057] Example 2 Preparation of long-acting microneedle patch for relieving depression containing paroxetine

[0058] Weigh 50 parts of catechol, 40 parts of sorbic acid, 60 parts of gelatin, 50 parts of dioctyl maleate, 10 parts of polyquaternium, 200 parts of glycerin, and 1000 parts of distilled water, and place them in a constant temperature water bath at 50 °C Heat for 30 minutes, add 10 parts of potassium persulfate as hair agent and 25 parts of methylenebisacrylamide as cross-linking agent after completely dissolving, heat up to 60°C while stirring in a constant temperature magnetic stirrer, keep the cross-linking reaction for 1 hour, A colorless and transparent gel-like hydrogel was obtained, which was purified in a 5000mL large beaker for distillation for 2 days, then taken out, and placed in a constant temperature drying oven at 50°C to fully dry to constant weight to obtain a hydrogel bonding layer.

[0059] Weigh 45 parts of calcium carbonate, 60 parts of N-methylp...

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Abstract

The invention relates to a long-acting depression relieving microneedle patch and preparation method thereof, and belongs to the technical field of transdermal or transdermal drug delivery preparations. The Long-acting depression relieving microneedle patch is composed of four layers of effective components, including a hydrogel fitting layer for fitting the skin, a degradable microneedle layer for puncturing the skin, a PDMS drug-loading layer serving as a drug storage tank for loading antidepressant drug components, and a waterproof non-woven fabric layer on the outermost layer. The microneedle is made of a biodegradable high polymer material containing calcium carbonate, the strength of the microneedle is effectively enhanced, the puncture performance of the microneedle is improved, and the microneedle can effectively penetrate through the skin cuticle. Amphipathic tetradecanol is used as a slow-release gate valve of a drug storage tank, on one hand, the amphipathic tetradecanol can wrap drugs with different hydrophilic and hydrophobic properties at the same time, and on the other hand, the slow-release performance is good, so that the microneedle patch can achieve the effect of continuously releasing the drugs for a long time. The manufacturing process is simple, the cost is low, and the safety is high.

Description

technical field [0001] The invention belongs to the technical field of transdermal or transdermal drug delivery preparations, and in particular relates to a long-acting depression-relieving microneedle patch and a preparation method thereof. Background technique [0002] Depression is caused by various physiological, organic or environmental reasons, with typical symptoms such as slow thinking, low emotion, slow movement, and reduced speech. Depression seriously plagues the life and work of patients. About 15% of patients with depression eventually die by suicide, which brings a heavy burden to the family and society. Research by the WHO shows that depression has become one of the disease burdens in China. big disease. [0003] The competition in modern society is fierce, the pressure of survival is high, and the incidence of depression is increasing year by year. At present, drugs are still the main treatment for this type of mental illness. Commonly used drugs include tr...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/42A61K47/32A61K47/34A61K47/02A61K47/10A61K45/06A61K36/88A61K36/41A61K36/355A61K36/534A61K31/138A61K31/4525A61K31/135A61K31/343A61K31/15A61P25/24A61M37/00
CPCA61K9/70A61K9/0021A61K47/32A61K47/34A61K47/02A61K47/10A61K47/42A61K45/06A61K36/88A61K36/41A61K36/355A61K36/534A61K31/138A61K31/4525A61K31/135A61K31/343A61K31/15A61P25/24A61M37/0015A61M2037/0053A61M2037/0046A61K2300/00
Inventor 李景华张建波高京丕陈美君李光大杨宪园
Owner HENAN UNIV OF SCI & TECH
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