Cyclic peptide capable of reducing insulin and properly reducing blood sugar at same time
A technology for insulin and blood sugar, applied in the direction of cyclic peptide components, enzymes, biochemical equipment and methods, etc., can solve the problems of no rise in blood sugar, no decrease in insulin, etc., and achieve the effects of lowering blood sugar, improving stability, and reducing amplitude
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Embodiment 1
[0022] In order to detect the stability of the peptide in the gastrointestinal tract, after incubation with simulated gastrointestinal fluid in vitro, it was found by HPLC-MS that the short peptide COX 52-69 Can exist stably in simulated gastrointestinal fluid.
Embodiment 2
[0024] The experimental group used the modified peptide COX 52-69 The SD rats were intragastrically administered, and the control group used the same dose of 0.9% normal saline to intragastrically administer the SD rats. Both groups were intragastrically administered 20% glucose solution, and at the end of 0, 30, 60, 90, and 120min Take blood from the vein, and use ELISA (enzyme-linked immunosorbent technique) to detect the insulin content in the blood supernatant, such as image 3 , the insulin concentration of the experimental group was significantly lower than that of the control group, and there was a statistically significant difference; Figure 4 , the increase in blood sugar in the experimental group was significantly lower than that in the control group, indicating that the cyclic peptide did not cause an increase in blood sugar while reducing insulin, but had a role in lowering blood sugar. Insulin is lowered without raising blood sugar, which can be used in many sit...
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