Nine-ingredient gardenia jasminoides flos carthami liniment for treating acute soft tissue injury and preparation method thereof

Abstract

The invention discloses a nine-ingredient gardenia jasminoides flos carthami liniment for treating acute soft tissue injury and a preparation method thereof, and relates to the technical field of medicines. The nine-ingredient gardenia jasminoides flos carthami liniment is prepared from 700 to 1300 parts of fructus gardeniae, 700 to 1300 parts of flos carthami, 350 to 650 parts of radix clematidis, 350 to 650 parts of radix angelicae sinensis, 210 to 390 parts of ground beeltle, 210 to 390 parts of borneol, 70 to 130 parts of frankincense, 70 to 130 parts of myrrh and 70 to 130 parts of dragon's blood. The preparation method comprises the following steps: each dose being 1 g, weighing the medicinal materials except borneol according to the prescription dosage ratio, uniformly mixing, crushing, sieving, soaking in 70-90% ethanol with the volume being 4-6 times that of the medicinal materials for 48 hours according to the ratio of 1g of the medicinal materials to 1ml of a solvent, slowly percolating, collecting initial percolation liquid for later use, adding 70-90% ethanol with the volume being 4-6 times that of the medicinal materials, slowly percolating, concentrating the percolation liquid under reduced pressure until the percolation liquid is free of alcohol smell, merging with the initial percolation liquid, and adding the crushed borneol according to the prescription dosage ratio, adding a proper amount of 95% ethanol to uniformly disperse, adding pure water to adjust the total amount of the solution to be 6.21-6.61 times of the total amount of the medicinal materials, uniformly shaking, and subpackaging to obtain the traditional Chinese medicine composition. The nine-ingredient gardenia jasminoides flos carthami liniment has good swelling and pain relieving effects on acute soft tissue injury.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of Jiuweizhihong liniment in the preparation of medicine for treating acute soft tissue injury. Background technique [0002] Acute soft tissue injury (acute soft tissue injury) is a common clinical orthopedic injury, usually refers to the closed injury of human muscles, tendons, ligaments, etc. , Yang Yanping, et al. Phase III clinical study of Heiguteng Shenjin Tougu Spray in the treatment of acute soft tissue injury (qi stagnation and blood stasis syndrome). Research on Integrative Traditional Chinese and Western Medicine, 2009, 1(5): 244-246.]. Common skin, subcutaneous tissue, fascia, muscle, tendon and ligament, periosteum, joint capsule and other soft tissue injuries, combined with peripheral nerve and blood vessel injuries; the main symptoms are bruising and ecchymosis, swelling and pain in the affected area, or accompanied by dysfunction [Zhang Guifu , ...

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Problems solved by technology

During the use of the above drugs, the curative effect is often poor, and it is easy to be accompanied by adverse reactions [McGettigan P, Henry D. Current problems with non-specific Cox inhibitors. Current pharmaceutical design, 2000, 6 (17): 1693-1724. Andres BM, Murrefi GAC. Treatment of tendinopathy: what works, what does not, and what is on the horizon. Clinical Orthopedics and Related Research, 2008, 466(7): 1539-1554.], even cause organ damage in severe cases [WrightHN.Chronic Toxicity studies of analgesic and antipyretic drugs and congeners. Toxicol and Applied Pharmacology, 1967, 11(2): 280-292. HeitWFW. Hematologic effects of antipyretic analgesics: drug-induced agranulocytosis. -69. Sharma S, PrasadA, Anand KS. Nonsteroidal anti-inflammatory drugs in the management of pain and inflammation: A basis for drug selection. American Journal of Therapeutics, 1999, 6(1): 3., 1999, 6(1) : 3-11. Hawkins C, Hanks GW. The gastroduodenal toxicity of nonsteroidal anti-inflammatory drugs. A review of the literature. Journal of Pain and Symptom Management, 2000, 20(2): 140-151.]

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