Controllable porous calcium phosphate scaffold and preparation method thereof

Abstract

The invention relates to a controllable porous calcium phosphate scaffold and a preparation method thereof. The calcium phosphate scaffold comprises calcium phosphate ceramic and calcium phosphate bone cement, the calcium phosphate scaffold is provided with a pore structure, the pore structure comprises a macro-pore structure, a micro-pore structure and a through-pore structure, and the calcium phosphate scaffold comprises crystal structures; and a through hole structure is arranged between the crystal structures, and the shape of the calcium phosphate stent is matched and designed according to the defect part of a patient. The preparation method of the sacrificial material is improved, a 3D printing technology with higher precision is selected, and more complex and diversified pore structures can be prepared; the prepared stent is provided with controllable micropores and through holes among crystals of the stent, the degradation rate of the stent is changed by controlling the pore structure, meanwhile, the ingrowth rate and ingrowth volume of new bones and blood vessels are affected by the pore structure, and therefore the biological activity and osteogenesis of the bone implantation stent are further improved; and the technological process is simple and easy to operate, and the prepared scaffold is stable in structural performance, high in compressive strength and good in cell compatibility.

Description

technical field [0001] The invention relates to the field of bone repair medical materials, in particular to a controllable porous calcium phosphate scaffold and a preparation method thereof. Background technique [0002] For orthopedic surgeons, the repair of large segmental bone defects caused by trauma, tumors, infections and congenital malformations is still a challenge. Such irregular bone defects require filling materials with good shape adaptability to fill the defect. . In recent years, with the continuous development of 3D printing technology, it is not difficult to prepare such scaffolds that require complex shapes and structures, but it is still difficult to prepare scaffolds that meet the conditions of bone repair in all aspects. [0003] At present, 3D printing is mostly direct printing, that is, the printing structure is equal to the final model, and the printing materials and printing methods need to be properly adapted, which means that various 3D printing m...

AI Technical Summary

Problems solved by technology

However, there are also disadvantages in the preparation of sacrificial molds by FDM. That is, because FDM uses nozzles to extrude molten materials, the printed structure is very limited, and the accuracy depends on the diameter of the nozzle. The diameter of the nozzle used in this patent is 0.3 mm, which cannot prepare fine structures. The through-pore structure is very single, and it may not be possible to prepare a pore-structured scaffold that is conducive to the growth of cells and tissues, which in turn affects the biological activity and osteoconductivity of the scaffold.

[0006] Therefore, a way of combining casting technology with 3D printing printing technology is designed, so that the scaffold has a microporous structure and through holes between micropores in the case of complex shapes and through macro holes; improved bone grafting The controllability of the pore structure in the stent is low, and the adjustable pore diameter range is small. Controlling the pore structure will change the degradation rate of the scaffold. At the same time, the pore structure will also affect the growth rate and volume of new bone and blood vessels. Bioactivity and osteogenicity of implanted scaffolds, it is necessary for those skilled in the art

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