Preparation method of polymer of lipoic acid compound

Abstract

The invention discloses a preparation method of a polymer of a lipoic acid compound. The preparation method is selected from a solvent-free direct hot-melting catalytic polymerization method or a room-temperature solution catalytic polymerization method. The catalyst used in the method is wide in source, easy to prepare and low in price, catalysis methods are diversified, the process is simple, metal ions are not contained, efficient catalysis can be achieved only through a trace amount of catalyst, and practical industrial feasibility is achieved; catalytic polymerization can be carried out under the condition that no solvent is directly heated and melted, and catalytic polymerization can also be carried out in a solution under the room temperature condition; the direct hot melting catalysis method does not need any organic solvent, has the advantages of rapid catalysis process, mild conditions, simple and safe operation, high atom utilization rate and no three wastes, and meets the green chemical requirements; according to the room-temperature solution catalysis method, heating and complex conditions are not needed, and efficient catalytic polymerization under the room-temperature condition can be achieved by adding a trace amount of catalyst into a monomer solution.

Description

technical field [0001] The invention belongs to the technical field of polymer material chemistry, and in particular relates to a preparation method of a polymer of lipoic acid compounds. Background technique [0002] Disulfide bond is a dynamic covalent bond that widely exists in living organisms. It is an important part of the secondary and tertiary structure of proteins and plays an important role in the stability of peptide chain structures and the formation of three-dimensional structures of protein molecules. Due to its relatively low bond energy (251kJ / mol), disulfide bonds have dynamic reversibility similar to supramolecular interactions, enabling the breaking and reconnecting of S-S bonds under external conditions. For cyclic compounds containing disulfide bonds, under certain conditions, the highly dynamic and reversible properties of disulfide bonds make the disulfide bonds break first in the molecule and then reconnect intermolecularly. Ring polymerization has s...

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Problems solved by technology

Direct thermal polymerization and photopolymerization mainly use the disulfide bond breakage under the action of heat or light to generate sulfur free radicals, and the sulfur free radicals between different molecules are connected to each other to form bonds again, so as to realize ring-opening polymerization, thermal polymerization and photopolymerization conditions Mild, simple process, fast preparation, high atom utilization, but there are also disadvantages such as difficulty in controlling the configuration and molecular weight, and the need for additional cross-linking agents to quench excess free radicals; the thiol induction method is passed in alkaline solution Sulfide anion triggers disulfide bond ring-opening polymerization chain reaction, the reaction can be completed at room temperature, high conversion rate can be achieved in a short time, and the structure of the polymer can be precisely controlled under specific conditions, but this The method needs to be carried out in a strictly anhydrous and oxygen-free organic solvent, which is not suitable for monomers containing carboxyl groups, and requires the participation of organic bases, mercaptans, and quenchers at the same time, and the reaction conditions are relatively complicated (Architecture-controlled ring-openingpolymerization for dynamic covalentpoly(disulfide)s[J].J.Am.Chem.Soc.,2019,141(43):17075-17080.)

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