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Graphene-enhanced hydrogel, graphene-enhanced hydrogel bacterial carrier, preparation method and application

A graphene and hydrogel technology, applied in the field of biomedical materials, can solve problems such as poor mechanical properties and thermal properties, limit applications, etc., and achieve the effect of hindering permeability, promoting establishment and balance, and slowing water loss rate.

Active Publication Date: 2022-01-18
SUZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] One of the objectives of the present invention is to provide a graphene-enhanced hydrogel to solve the problem of poor mechanical and thermal properties of the existing hydrogel system formed by crosslinking sodium alginate and divalent cations, which limits its use in biological Technical issues for applications in the field of materials

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  • Graphene-enhanced hydrogel, graphene-enhanced hydrogel bacterial carrier, preparation method and application
  • Graphene-enhanced hydrogel, graphene-enhanced hydrogel bacterial carrier, preparation method and application
  • Graphene-enhanced hydrogel, graphene-enhanced hydrogel bacterial carrier, preparation method and application

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preparation example Construction

[0059] According to a second aspect of the present invention, the present invention provides a method for preparing graphene-enhanced hydrogel, comprising the following steps:

[0060] The amphiphilic graphene is added to the sodium alginate solution, and then the calcium lactate solution is added, so that the sodium alginate and calcium ions undergo a cross-linking reaction to obtain a graphene-enhanced hydrogel.

[0061] According to the third aspect of the present invention, the present invention provides the application of the graphene-enhanced hydrogel in the preparation of bacteria, drugs or gene carriers.

[0062] Preferably, the bacteria include fecal bacteria, which refers to an extract of intestinal fecal bacteria.

[0063] The graphene-enhanced hydrogel provided by the invention can also be used to prepare medicaments for treating chronic diarrhea.

[0064] According to a fourth aspect of the present invention, the present invention provides a graphene-enhanced hyd...

Embodiment 1

[0079] This embodiment provides a graphene-enhanced hydrogel, which is prepared according to the following steps:

[0080] Dissolve 2.54g sodium alginate and 0.1g amphiphilic graphene in 80.96g deionized water, dissolve 1.4g calcium lactate in 15g deionized water, drop the calcium lactate solution into the mixed solution of sodium alginate-amphiphilic graphene , to obtain a graphene-enhanced hydrogel, wherein the mass proportion of calcium alginate is 2.5%, the mass proportion of sodium lactate is 1.5%, the mass proportion of amphiphilic graphene is 0.1%, and the mass proportion of water is 95.9%. .

[0081] Wherein, amphiphilic graphene is prepared according to the following steps:

[0082] Mix 10g of hexamethylene diisocyanate (sufficient excess) with 1g of graphene oxide in anhydrous N, N-dimethylformamide (DMF), and react at 80°C for 12h. One end of hexamethylene diisocyanate Isocyanate reacts with the carboxyl or hydroxyl groups on the graphene oxide surface, and is con...

Embodiment 2

[0084] The present embodiment provides a graphene-enhanced hydrogel, which differs from Example 1 in that the quality of adding amphiphilic graphene is 2.5 g, and in the obtained graphene-enhanced hydrogel, calcium alginate The mass proportion is 0.5%, the mass proportion of sodium lactate is 0.3%, the mass proportion of amphiphilic graphene is 2.5%, and the mass proportion of water is 96.7%.

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Abstract

The invention provides a graphene-enhanced hydrogel, a graphene-enhanced hydrogel bacterial carrier, a preparation method and an application thereof, and relates to the technical field of biomedical materials. The graphene-enhanced hydrogel comprises the following components in mass percentage: Composition: 0.1‑5% amphiphilic graphene, 0.25‑3% sodium lactate, 0.5‑5% calcium alginate, and the balance is water. The graphene-enhanced hydrogel provided by the present invention not only has excellent biocompatibility, but also has excellent mechanical properties and water retention stability, and can also hinder the permeability of oxygen and prolong the in vitro storage time of anaerobic bacteria. Used as a carrier of bacterial drugs, it can effectively expand the application range of the hydrogel.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a graphene-enhanced hydrogel, a graphene-enhanced hydrogel bacterial carrier, a preparation method and an application thereof. Background technique [0002] Hydrogel is a hydrophilic polymeric material with a network structure. The hydrophilic polymer chains are cross-linked to form a three-dimensional solid, and water acts as a dispersion medium. Hydrogel materials have excellent biocompatibility and ion transport ability, so that they have the potential to be widely used in medical fields such as bionic materials and artificial tissues. [0003] Sodium alginate is a naturally occurring copolymer known for its ability to interact with Ca 2+ It is well known for its gelling properties of polyvalent metal ions. As a natural, low-cost, easy-to-obtain polysaccharide with good biocompatibility, it has been widely used in the food industry and has received extensive att...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/36A61K47/04A61K47/12A61K47/32A61K47/34A61K9/06A61K35/74A61K35/747A61K35/744A61K31/12A61P1/12A61P25/24A61P1/00B01J13/00C01B32/194
CPCA61K47/36A61K47/02A61K47/12A61K47/32A61K47/34A61K9/06A61K35/74A61K35/747A61K35/744A61K31/12A61P1/12A61P25/24A61P1/00B01J13/0052B01J13/0056B01J13/0065C01B32/194
Inventor 刘梓瑞王晶张玉珊李嫄渊焦旸曹建平祁小飞张琦
Owner SUZHOU UNIV
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