Cosmetic for repairing and relieving skin irritation and preparation method thereof

A technology for skin irritation and cosmetics, applied in cosmetic preparations, cosmetics, preparations for skin care, etc., can solve problems such as skin barrier dysfunction repair, and achieve the effect of restoring skin barrier function, excellent skin beautifying effect, and relieving skin irritation.

Active Publication Date: 2021-07-27
COSMAX CHINA INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to solve the defect that the existing technology cannot fundamentally solve the problem of repairing skin barrier dysfunction, the present invention uses the combination of Monascus fermented product extract and comfrey extract to repair the skin epidermal barrier in an all-round way. Inflammation vicious cycle" latest research results, developed a new skin barrier function, relieve skin irritation moisturizing composition and its external preparation

Method used

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  • Cosmetic for repairing and relieving skin irritation and preparation method thereof
  • Cosmetic for repairing and relieving skin irritation and preparation method thereof
  • Cosmetic for repairing and relieving skin irritation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Embodiment 1: preparation method of Monascus fermented product extract

[0049] 1. Fermentation method of Monascus fermented product:

[0050] (1) Liquid seed culture: Weigh about 5g of Daqu powder into a 250mL Erlenmeyer flask, add about 30mL of sterile water, shake for 30 minutes to make a bacterial suspension, take the bacterial suspension and inoculate it in the proliferation medium, at 30°C, Cultivate at 120r / min for 4 days to obtain liquid seed solution.

[0051] (2) Solid-state fermentation: select some glutinous rice, open it evenly, and place it in a constant temperature environment of 50°C for drying. Then weigh 100g and pour it into a conical flask with a volume of 500mL. Select some pure water and put it in a beaker, add lactic acid to it until the pH of the solution is 5.0, pour the solution into a horn bottle until the liquid level is 5cm above the top of the glutinous rice. Soak for 12 hours and gently shake the triangular flask, and visually check tha...

Embodiment 2

[0059] Embodiment 2: preparation method of comfrey extract

[0060] Dried xinjiang comfrey, crushed and sieved to 60 mesh, sterilized and placed in an extraction tank, added ethylhexyl palmitate (10ml / g), left to soak at room temperature for 24 hours, and centrifuged to obtain a comfrey extract.

Embodiment 3

[0062] In vitro experiments were conducted to investigate the effect of red yeast rice extract combined with comfrey extract on the secretion of ceramide, free fatty acid and hyaluronic acid from keratinocyte cell line HEKa cells, so as to evaluate its repairing effect on skin barrier function.

[0063] 1. Test sample processing

[0064] Dissolve comfrey extract in DMSO, then add Monascus ferment extract, and finally add Epilife TM Culture medium, according to the ratio and specific feeding in Table 1 and Table 2, configure different Epilife TM Media mix solution. Among them, there are 7 groups of compositions with different ratios, and 3 groups of comparative examples.

[0065] Table 1 Cell test ratio

[0066]

[0067]

[0068] Table 2 Composition of each component of the cell test

[0069]

[0070] 2. Cell culture

[0071] HEKa cells from normal human skin were treated with Epilife containing 1% HKGS (Human Keratinocyte Growth Supplement) TM Culture medium (co...

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Abstract

The invention discloses a cosmetic for repairing and relieving skin irritation and a preparation method thereof. The composition comprises a monascus fermentation product extract and a lithospermum extract. Cell tests find that the composition has a synergistic effect and can effectively promote skin cells to secrete hyaluronic acid, ceramide and free fatty acid; and after a human body test, the skin of a volunteer is obviously improved, and the skin moisture content and the skin barrier function are well improved.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and relates to a cosmetic for repairing and alleviating skin irritation and a preparation method, in particular to a cosmetic composition comprising a combination of a monascus fermented product extract and a comfrey extract. Background technique [0002] The skin is the largest organ of the human body and plays an important role in human immunity; the skin can be roughly divided into 3 layers, which are subcutaneous tissue, dermis, and epidermis from the inside to the outside; the epidermis can be divided into the basal layer and spinous layer , granular layer, transparent layer, stratum corneum. The stratum corneum is in direct contact with the external environment and provides a physical immune barrier for the skin. The skin barrier is composed of keratin in the stratum corneum of the skin surface, a brick wall structure formed by intercellular lipids, and mucopolysaccharides. Among them, i...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/9728A61Q19/00
CPCA61K8/9789A61K8/9728A61Q19/00A61K2800/85
Inventor 朱云周秋娜金炫延金荣熙申彦晟金延埈
Owner COSMAX CHINA INC
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