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Multifunctional compound stent as well as preparation method and application thereof

A complex and multifunctional technology, applied in the field of biomedical materials, can solve the problems of single function, difficulty in completely removing residual tumor cells, and low efficiency in treating tumors, and achieve enhanced effects

Inactive Publication Date: 2021-07-13
THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of this, the present application provides a multifunctional composite scaffold and its preparation method and application, which can efficiently kill residual tumor cells while filling bone defects, and can effectively solve the problem of single function and low therapeutic effect of existing scaffolds for treating bone cancer. The efficiency of the tumor is not high, and the technical problems that the residual tumor cells are difficult to completely remove

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  • Multifunctional compound stent as well as preparation method and application thereof
  • Multifunctional compound stent as well as preparation method and application thereof
  • Multifunctional compound stent as well as preparation method and application thereof

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Embodiment 1

[0089] The embodiment of the present application provides the preparation method of BGC powder, BGC scaffold and BGC scaffold mixed with heme (HM) and doxorubicin (DOX), specifically including:

[0090] 1. Preparation of BGC powder (bioactive glass-ceramic powder): BGC powder was prepared by a sol-gel method. The process is described as follows: 156.81 mLTEOS (tetraethyl tetrasilicate) was added to 200 mL deionized water, followed by 25.00 mL HNO 3 Solution (2moL / L) was added to the above solution and stirred for 30min. Next, 59.04g Ca(NO 3 ) 2 4H 2 O and 8.53mLTEP (triethyl phosphate) were added to the above solution and stirred for 6h. Then, the solution was placed in an air oven at 65°C for 24h, and then the product was dried in an air oven at 120°C for 48h. The dried product was transferred to a planetary high-energy ball mill and ground at a speed of 600 rpm for 4 h. Then the product was calcined in a high-temperature sintering furnace with a maximum temperature of ...

Embodiment 2

[0094] The embodiment of the present application provides a preparation method of BGC-HM scaffolds mixed with different proportions of heme HM, including:

[0095] 1. Add the heme powder into deionized water, and grind it at a speed of 500 rpm for 4 hours by a planetary high-energy ball mill. After grinding, the heme powder is dried and collected. Add 0.1 g of polylactic acid to 5 mL of dichloromethane, and stir to completely dissolve it. Then, three different weights of heme powder (0.02g, 0.06g and 0.12g) were put into the above polylactic acid solution in dichloromethane, respectively. After stirring for 10 minutes and ultrasonically dispersing for 30 minutes, mixed solutions of heme and polylactic acid were obtained, which were marked as 1HM mixed solution, 2HM mixed solution and 3HM mixed solution.

[0096] 2. Immerse the BGC stent prepared in Example 1 into 1HM mixed solution, 2HM mixed solution and 3HM mixed solution respectively. After the BGC scaffolds were complet...

Embodiment 3

[0102] The embodiment of the present application provides a method for preparing BGC-HM scaffolds mixed with different ratios of doxorubicin, including:

[0103] 1. Weigh 2mg, 5mg, 10mg and 15mg of doxorubicin, add doxorubicin to 5mL of polylactic acid in dichloromethane solution respectively, the concentration of polylactic acid in the polylactic acid in dichloromethane solution is 0.02g / mL . After stirring and ultrasonic dispersion, the BGC scaffold was immersed in the above mixed solution for 4 s, and then taken out.

[0104] 2. The stents were respectively immersed in polylactic acid dichloromethane solutions containing 2mg, 5mg, 10mg and 15mg of doxorubicin, and the taken out stents were named as BGC-1DOX, BGC-2DOX, BGC-3DOX and BGC-4DOX stents.

[0105] 3. Detect the appearance, SEM, red fluorescence and doxorubicin release of the above-mentioned BGC-1DOX, BGC-2DOX, BGC-3DOX and BGC-4DOX scaffolds, the results are as follows image 3 shown. image 3 A is the appearanc...

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Abstract

The invention belongs to the technical field of biomedical materials, and particularly relates to a multifunctional compound stent as well as a preparation method and application thereof. The multifunctional composite scaffold comprises a bone tissue scaffold and a functional layer, the functional layer is arranged on the surface of the bone tissue stent and comprises a photo-thermal layer and a medicine carrying layer; or, the functional layer is a mixed layer, and the mixed layer comprises a photo-thermal reagent and a chemotherapeutic drug. The preparation method of the bone tissue scaffold comprises the following steps: acquiring bone medical image data of a part to be implanted, converting the bone medical image data into three-dimensional model data of bones, and preparing the bone tissue scaffold through 3D printing processing according to the three-dimensional model data. The invention provides a multifunctional compound scaffold as well as a preparation method and application thereof, which can efficiently kill residual tumor cells and fill postoperative bone defect positions at the same time, and can effectively solve the technical problems of single function, low tumor treatment efficiency and difficulty in removing the residual tumor cells in the existing scaffold for treating bone cancer.

Description

technical field [0001] The application belongs to the technical field of biomedical materials, and in particular relates to a multifunctional composite scaffold and its preparation method and application. Background technique [0002] The incidence of bone metastasis of bone tumors and metastatic tumors is increasing year by year, which brings great pain to patients. At present, the main method for clinical treatment of bone tumors is surgical resection combined with chemotherapy; however, surgery will cause large bone defects that will affect the body's motor function, and it is usually difficult to completely remove tumor cells, and residual cancer cells are the cause of The main cause of tumor recurrence. While systemic chemotherapy kills tumor cells, it also damages normal tissue cells, causing systemic side effects to patients. In addition, long-term chemotherapy can make bone cancer cells develop drug resistance and reduce the body's immunity. Therefore, the develop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/10A61L27/28A61L27/50A61L27/54A61L27/12A61L27/02A61K41/00A61K31/704A61K31/513A61K31/337A61K31/555A61P35/00A61P35/04B33Y10/00B33Y70/10B33Y80/00
CPCA61L27/10A61L27/28A61L27/50A61L27/54A61L27/12A61L27/025A61K41/0052A61K31/704A61K31/513A61K31/337A61K31/555A61P35/00A61P35/04B33Y10/00B33Y70/10B33Y80/00A61L2300/416A61L2420/02A61L2420/08A61L2300/608A61K2300/00
Inventor 李明强陶玉雎恩国党文涛金圆圆易可
Owner THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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