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High-orientation and high-strength bacterial cellulose composite membrane as well as preparation and application thereof

A technology of bacterial cellulose film and bacterial cellulose, which is applied in bandages, absorbent pads, medical science, etc., can solve the problems of poor biocompatibility and low mechanical strength, and achieve the promotion of wound healing, simple preparation process, and promotion of The effect of cell migration

Active Publication Date: 2021-07-09
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The invention solves the technical problems that the patterned bacterial cellulose membrane has no directional arrangement of fibers, low mechanical strength and poor biocompatibility in the prior art

Method used

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  • High-orientation and high-strength bacterial cellulose composite membrane as well as preparation and application thereof
  • High-orientation and high-strength bacterial cellulose composite membrane as well as preparation and application thereof
  • High-orientation and high-strength bacterial cellulose composite membrane as well as preparation and application thereof

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preparation example Construction

[0040] A kind of preparation method of the bacterial cellulose composite membrane of high orientation and high strength of the present invention comprises the following steps:

[0041] (1) By adopting the method of mechanical stretching, bacterial cellulose with a length of 8cm-15cm (preferably 12cm) and a width of 1cm-8cm (preferably 4cm) is used to prepare bacterial cellulose (BC) with different tensile strains. ); Tensile strain is less than or equal to 40% (preferably 40%);

[0042] (2) soak the bacterial cellulose (BC) film prepared in step (1) into a certain concentration of natural polymer solution, the soaking time is 3h-24h (preferably 6h), and the temperature is 30-50°C (preferably 37° C.), and shake fully on a shaker at a speed of 50-200 rpm (preferably 150 rpm), and then form a bacterial cellulose composite film under the action of a crosslinking agent. The specific reaction is that under the action of the cross-linking agent, the carboxyl group on the natural pol...

Embodiment 1

[0048] (1) Cutting the original BC film to a length of 12 cm and a width of 4 cm; preparing a BC with a tensile strain of 20% by mechanical stretching;

[0049] (2) Soak the BC membrane prepared in step (1) into a 1% gelatin solution, fully shake it on a shaker for 6 hours, the temperature is 37°C, and the shaking speed is 150rpm, and then put it in the EDC / NHS cross-linking agent The BC / gelatin composite film was formed by cross-linking for 4 hours, and washed three times with deionized water.

[0050] (3) Hot pressing the BC / gelatin composite film prepared in step (2), the hot pressing stress is 100N; the hot pressing temperature is 60°C; the hot pressing time is 24h; Composite film of BC / gelatin.

Embodiment 2

[0052] The difference between this embodiment and embodiment 1 is that the tensile strain of BC is different, and the tensile strain of this embodiment is 30%.

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Abstract

The invention discloses a high-orientation and high-strength bacterial cellulose composite membrane as well as preparation and an application thereof, and belongs to the technical field of biological manufacturing. The preparation method comprises the following steps: mechanically stretching a bacterial cellulose membrane to obtain a bacterial cellulose membrane with tensile strain; and soaking the obtained bacterial cellulose membrane with the tensile strain in a natural polymer solution, and then adding a cross-linking agent, so that the bacterial cellulose membrane with the tensile strain is cross-linked with the natural polymer to obtain the bacterial cellulose composite membrane. The composite membrane not only has fiber orientation, very high mechanical property and biocompatibility, but also can promote cell migration and adhesion and rapidly induce skin tissue regeneration; besides, the membrane coupling electrical stimulation can synergistically promote cell migration and skin tissue regeneration, dual combination of orientation induction and electrical stimulation induction is realized, a new way is provided for wound healing dressing, and biomedical application of the bacterial cellulose is widened.

Description

technical field [0001] The invention belongs to the technical field of biomanufacturing, and more specifically relates to a highly oriented and high-strength bacterial cellulose composite film as well as its preparation and application. Background technique [0002] Wound healing is a complex but orderly biological process, including four processes of inflammation, granulation tissue formation, tissue remodeling and re-epithelialization, in which cell migration plays an important role. During wound healing, fibroblasts migrate toward the alignment of collagen, which contributes to the production of extracellular matrix (ECM) and matrix remodeling, thereby promoting wound healing. Conversely, loss of cell motility and disordered cell migration may lead to physiological abnormalities that ultimately lead to failure of wound healing. Therefore, it is of great significance to establish a wound treatment method to regulate cell migration to promote wound healing. Wound dressing...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/32A61L15/42C08J7/00C08J3/24C08L1/02
CPCA61L15/28A61L15/325A61L15/32A61L15/42C08J7/00C08J3/246C08J2301/02C08J2489/00C08J2405/08C08L1/02
Inventor 杨光王蠡石志军毛琳亓福玉
Owner HUAZHONG UNIV OF SCI & TECH
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