Preparation method of 2, 4, 6-trichlorophenyl substituted acetone

Abstract

The invention relates to a preparation method of 2, 4, 6-trichlorophenyl substituted acetone, which comprises the following steps: adding 2, 4, 6-trichlorotoluene and a chlorination reagent into an organic solvent at a certain temperature to prepare 2, 4, 6-trichlorophenyl benzyl chloride, then coupling with ethynyl magnesium halide under the action of a metal catalyst, and then carrying out acid catalysis and water addition to finally obtain the product 2, 4, 6-trichlorophenyl substituted acetone. The method provided by the invention has the advantages of many raw material sources, obvious cost advantage, safer and more convenient preparation method, high total yield and less three wastes, and is beneficial to industrialization.

Description

technical field [0001] The invention relates to a preparation method of 2,4,6-trichlorophenyl substituted acetone, in particular to a method for preparing 2,4,6-trichlorotoluene through halogenation, metal-catalyzed Grignard reagent coupling, and acid-catalyzed alkyne water addition. A method for the preparation of 2,4,6-trichlorophenyl substituted acetone. Background technique [0002] 2,4,6-Trichlorophenyl substituted acetone is often used in the synthesis of medicines and pesticides, especially as an intermediate of the fungicide flufenapyramide, which has received much attention and research. There are mainly two synthetic methods reported in the literature. : The first one uses 2,4,6-trichlorobenzaldehyde as a raw material to obtain the target product through condensation with nitroethane and reduction of iron powder. The raw material price of 2,4,6-trichlorobenzaldehyde is high and the supply At the same time, a large amount of iron sludge is produced during the reduc...

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Problems solved by technology

[0002] 2,4,6-Trichlorophenyl substituted acetone is often used in the synthesis of medicines and pesticides, especially as an intermediate of the fungicide flufenapyramide, which has received much attention and research. There are mainly two synthetic methods reported in the literature. : The first one uses 2,4,6-trichlorobenzaldehyde as a raw material to obtain the target product through condensation with nitroethane and reduction of iron powder. The raw material price of 2,4,6-trichlorobenzaldehyde is high and the supply At the same time, a large amount of iron sludge is produced during the reduction of iron powder, causing environmental pollution, and the three wastes are more difficult to release to the production stage; the second type uses 2,4,6-trichloroaniline as raw material, after diazotization reaction and propylene acetate The target product is prepared by the reaction. The safety risk of the diazotization reaction is high and the reaction yield is not high, which causes safety and cost problems and is difficult to scale up to the production stage.

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