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Bifidobacterium lactis and purpose thereof in acceleration of growth and development of children and adolescents

A technology of bifidobacterium lactis and teenagers, applied in the field of microorganisms, can solve problems such as low IQ, achieve the effect of improving metabolic disorders and promoting growth and development

Active Publication Date: 2021-06-18
ZHONGKE WISBIOM(BEIJING)BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The cause of the disease is a gene defect on chromosome 15. The child has normal language ability, but the actual IQ is lower than that of ordinary people.

Method used

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  • Bifidobacterium lactis and purpose thereof in acceleration of growth and development of children and adolescents
  • Bifidobacterium lactis and purpose thereof in acceleration of growth and development of children and adolescents
  • Bifidobacterium lactis and purpose thereof in acceleration of growth and development of children and adolescents

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] This example is used to illustrate Bifidobacterium lactis BL-11 and its performance characteristics.

[0050] 1. Taxonomic characteristics of Bifidobacterium lactis BL-11:

[0051] Observing Bifidobacterium lactis BL-11 under a microscope, the results are as follows figure 1 shown. The physical and chemical test results are shown in Tables 1 and 2.

[0052] Table 1

[0053]

[0054] Table 2

[0055]

[0056] + means able to metabolize; - means unable to metabolize.

[0057] 2. Artificial gastric juice and intestinal juice tolerance of Bifidobacterium lactis BL-11:

[0058] Bifidobacteria are a genus of bacteria that are generally not acid fast. In this example, the tolerance of artificial gastric juice and intestinal juice of Bifidobacterium lactis BL-11 of the present invention is tested. At the same time, the Bifidobacterium lactis Bb which is currently preserved in the laboratory has excellent acid resistance and can survive through the gastrointestinal t...

Embodiment 2

[0068] This example is used to illustrate the functional characteristics of Bifidobacterium lactis BL-11 in promoting growth and development.

[0069] The microbiota, promotes bone formation as well as resorption, resulting in net bone growth. The microbiota induces the hormone-like insulin growth factor 1 (IGF-1), which promotes bone growth and remodeling. Short-chain fatty acids (SCFAs) produced by the microbiota fermenting fibers also induced IGF-1, suggesting a mechanism by which the microbiota affects bone health.

[0070] Two-month-old female BALB / c mice were treated with antibiotics and probiotics and housed under SPF conditions. Thirty mice were pooled and randomly assigned to treatment groups to minimize cage effects. Antibiotics were a mixture of 0.2 mg / mL gentamicin, 0.15 mg / mL ciprofloxacin, 2 mg / mL streptomycin and 1 mg / mL bacitracin.

[0071] First, the mice were treated with an antibiotic mixture added to their drinking water for 2 weeks to deplete the microo...

Embodiment 3

[0077] This example is used to illustrate the preparation of BL-11 bacterial powder and its use in food production.

[0078] The bifidobacterium lactis BL-11 provided by the invention is anaerobically cultured in MRS broth liquid medium. After primary, secondary and expanded culture, the fermentation broth was cultured at 37°C for 24h, then centrifuged at 4°C and 3000rpm for 10min to collect the bacteria, washed with phosphate buffer saline (PBS), added skim milk for freeze-drying , Store below -20°C.

[0079] The BL-11 bacterial powder prepared in this example can be used for food, medicine, health products or animal feed.

[0080] The food can be common food or health food such as fermented milk, cheese, milk beverage, solid beverage, milk powder, etc. Preferably, in the food, the recommended dose of Bifidobacterium lactis BL-11 for human use can be 1.0×10 3 CFU~1.0×10 10 CFU / kg body weight / day, more preferably 1.0×10 4 CFU~1.0×10 9 CFU / kg body weight / day.

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Abstract

The invention relates to Bifidobacterium lactis. The Bifidobacterium lactis is Bifidobacterium lactis BL-11 of which the collection number is CGMCC No.20847. The Bifidobacterium lactis provided by the invention can eliminate intestinal tract metabolic disorders and can cause the composition of an intestinal tract microbiome to be normalized so as to effectively improve height, inhibit obesity and accelerate the growth and development as well as intellectual development of children and adolescents.

Description

technical field [0001] The present disclosure relates to the technical field of microorganisms, in particular to a bifidobacterium lactis and its use in promoting the growth and development of children and adolescents. Background technique [0002] Studies have found that intestinal bacteria can affect the growth and development of the host, and some flora can mediate the growth and development of the host by affecting growth hormone (GH) / insulin-like growth factor-1 (IGF-1). Both germ-free and antibiotic-treated mice showed reduced growth, which was associated with reduced levels of ghrelin, growth hormone, and IGF-1. Furthermore, in both mice and humans, a lack of microbes leads to maturation and growth restriction, such as chronic malnutrition, anorexia nervosa, growth retardation, short stature and even abnormal development of the nervous and immune systems. Growth retardation and short stature are closely related to bone and muscle growth and development. The growth, ...

Claims

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Application Information

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IPC IPC(8): C12N1/20A23C9/123A23C9/16A23C19/032A23C19/06A23K10/18A23L33/135A61K35/745A61P1/00A61P3/02A61P3/04A61P25/00A61P25/28C12R1/01
CPCC12N1/20A23C9/1234A23C19/0323A23C19/062A23C9/16A23L33/135A23K10/18A61K35/745A61P1/00A61P3/02A61P3/04A61P25/00A61P25/28A23V2400/531
Inventor 段云峰张烨梁桦刘智
Owner ZHONGKE WISBIOM(BEIJING)BIOTECHNOLOGY CO LTD
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