Preparation method of high-sensitivity self-cleaning type blood oxygen sensor based on photonic crystal fluorescence enhancement

A technology of photonic crystals and fluorescence enhancement, which is applied in the field of fluorescent oxygen sensors, can solve the problems of fluorescence signal weakening, indicator leakage, etc., and achieve the effects of improving hydrophobicity, preventing indicator leakage, and simple preparation process

Active Publication Date: 2021-06-15
HARBIN INST OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims to solve the problems of indicator leakage and weakened fluorescence signal when the optical oxygen sensor prepared by the existing method is used for blood oxygen detection, and provides a method for preparing a high-sensitivity self-cleaning blood oxygen sensor based on photonic crystal fluorescence enhancement

Method used

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  • Preparation method of high-sensitivity self-cleaning type blood oxygen sensor based on photonic crystal fluorescence enhancement
  • Preparation method of high-sensitivity self-cleaning type blood oxygen sensor based on photonic crystal fluorescence enhancement
  • Preparation method of high-sensitivity self-cleaning type blood oxygen sensor based on photonic crystal fluorescence enhancement

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specific Embodiment approach 1

[0036] Specific Embodiment 1: In this embodiment, a method for preparing a high-sensitivity self-cleaning blood oxygen sensor based on photonic crystal fluorescence enhancement includes the following steps:

[0037] 1. Swelling of polystyrene microspheres

[0038] The polystyrene microsphere emulsion was placed in a light-proof container, and PtOEP / THF fluorescent dye was added, and then ultrasonicated at room temperature. Water redisperses the precipitate to obtain a dispersed microsphere emulsion;

[0039] 2. Preparation of Photonic Crystal Fluorescence Enhanced Oxygen Sensor

[0040] Add the polysorbate solution to the dispersed microsphere emulsion in step 1, ultrasonically treat until mixed evenly, and then place it in a flat-bottomed glass tube;

[0041] Put the hydrophilized quartz slices obliquely into a flat-bottomed glass tube, and place them together in a water-proof incubator. The temperature of the incubator is set at 60-65°C until the emulsion is completely eva...

specific Embodiment approach 2

[0044] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the mass concentration of the polystyrene microsphere emulsion in Step 1 is 0.4%. Others are the same as in the first embodiment.

[0045] The polystyrene microspheres in this embodiment have a uniform particle size and are purchased.

specific Embodiment approach 3

[0046] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is that the preparation method of PtOEP / THF fluorescent dye in step one is: dissolving platinum octaethylporphyrin powder (PtOEP) in tetrahydrofuran, and preparing to obtain The indicator concentration is 1×10 -3 mol / l PtOEP / THF fluorescent dye. Others are the same as in the first or second embodiment.

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Abstract

The invention discloses a preparation method of a high-sensitivity self-cleaning type blood oxygen sensor based on photonic crystal fluorescence enhancement, and relates to the field of a fluorescent oxygen sensor, in particular to a preparation method of a blood oxygen sensor based on photonic crystal fluorescence enhancement. The invention is to solve the problems of leakage of an indicator and weakened fluorescence signal when a blood oxygen sensor prepared through an existing method is used for blood oxygen detection. The method comprises the steps of: 1, placing polystyrene microsphere emulsion in a light resistant container, adding a fluorescent dye, carrying out ultrasonic treatment, swelling in a dark box at the room temperature, carrying out centrifugation, and re-dispersing precipitates with pure water to obtain dispersed microsphere emulsion; and 2, adding polysorbate solution into the microsphere emulsion, carrying out ultrasonic treatment, and putting into a flat-bottomed glass tube; obliquely putting a quartz plate into the flat-bottomed glass tube, and putting the flat-bottomed glass tube and the quartz plate into a waterproof incubator together until the emulsion is completely evaporated, so as to obtain a photonic crystal device; and spin-coating a layer of PDMS on the surface of the prepared photonic crystal device, and curing to obtain the blood oxygen sensor. The invention is applied to the field of the sensor.

Description

technical field [0001] The invention relates to the field of fluorescent oxygen sensors, in particular to a preparation method of a blood oxygen sensor based on photonic crystal fluorescence enhancement. Background technique [0002] In recent years, people's health awareness is also increasing while the living standard of residents is improving, and more and more cardiovascular diseases have attracted widespread attention. Blood oxygen saturation is one of the important physiological indicators directly related to such diseases. Oxygenated hemoglobin (HbO 2 ) in total hemoglobin (Hb), that is, the concentration of blood oxygen in the blood, which is an important physiological parameter of the life cycle. When some organs in the living body are in a state of hypoxia for a long time, they will not be able to perform their physiological functions normally, causing tissue edema, decreased defense function, and seriously affecting the blood circulation in the human body. In a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/1455C09D125/04C09D5/22
CPCC09D125/04C09D5/22A61B5/14552A61B5/14556C08K5/0091
Inventor 张科陈赛赵九蓬李垚
Owner HARBIN INST OF TECH
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