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Application of prunus cerasifera product in inhibition of thrombosis

A cherry and product technology, applied in the application field of cherry plum products in inhibiting thrombosis, can solve problems such as bleeding, and achieve the effect of inhibiting thrombosis and preventing thrombosis

Active Publication Date: 2021-06-04
NATURAL MEDICINE INST OF ZHEJIANG YANGSHENGTANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although antiplatelet drugs have been widely used to prevent and treat coronary artery and cerebrovascular thrombosis, almost all antiplatelet drugs have the risk of bleeding

Method used

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  • Application of prunus cerasifera product in inhibition of thrombosis
  • Application of prunus cerasifera product in inhibition of thrombosis
  • Application of prunus cerasifera product in inhibition of thrombosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1: the preparation of cherry plum extract A

[0056] The preparation process is as follows:

[0057] (1) Clean the cherry plum red fruit, add water to beat (solid-liquid ratio 1:1), filter to obtain filtrate and filter residue;

[0058] (2) Take the filter residue and add water (material-to-liquid ratio 1:1), heat to 80°C for 1 hour, filter to obtain the filtrate, and discard the filter residue;

[0059] (3) Combine the filtrates obtained in (1) and (2), heat to 50° C. and concentrate the combined filtrates, which is Plum Cherry Extract A.

Embodiment 2

[0060] Example 2: Preparation of Cherry Plum Extracts B and C

[0061] In this example, using a procedure similar to that of Example 1, Prunus cerevisiae and Prunus cerevisiae were respectively used to prepare extracts B and C of Prunus cerevisiae.

Embodiment 3

[0062] Example 3: Effects of Cherry Plum Extracts A-C on Thrombosis in Zebrafish

[0063] 1 Experimental principle

[0064] ADP can bind to P2Y1 and P2Y2 receptors on the surface of platelets to activate platelets; activated platelets can release endogenous ADP, which cascades and amplifies the aggregation reaction of platelets, and then forms thrombus. After ADP induced thrombus in zebrafish, the erythrocytes returning to the heart decreased, which was manifested by the weakened staining intensity of erythrocytes in the heart.

[0065] 2 Experimental methods

[0066] a) AB wild-type zebrafish embryos were collected and cultured in E3 buffer in an incubator at 28°C; the water was changed every other day, and dead embryos were picked out.

[0067] b) Select juvenile fish whose embryonic development phase is 2dpf, and randomly divide them into 5 groups:

[0068] Normal group: normal feeding with E3 buffer;

[0069] Solvent group: fed with E3 buffer containing 1% DMSO;

[00...

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PUM

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Abstract

The invention relates to the field of food and medicine, in particular to an application of a prunus cerasifera product in inhibition of thrombosis. The prunus cerasifera product comprises jam, dried fruits, preserved fruits, fruit juice, fruit powder, fruit wine, candies, pastries, oral liquid, fresh prunus cerasifera fruits and the like. Animal experiments show that the antithrombotic capability of a prunus cerasifera extract is equivalent to that of aspirin, and thrombosis caused by adenosine diphosphate or carrageenan can be effectively prevented and treated.

Description

technical field [0001] The invention relates to the fields of food and medicine, in particular to the application of cherry plum products in inhibiting thrombus formation. Background technique [0002] Thrombus refers to abnormal blood clots formed in blood vessels by formed components in circulating blood during the survival of humans and animals, or blood deposits occur on the inner wall of the heart or on the walls of blood vessels. Vascular obstruction caused by thrombus formation is the main mechanism for inducing cardiovascular and cerebrovascular emergencies. Antithrombotic therapy has become one of the important strategies for the treatment of cardiovascular and cerebrovascular diseases. [0003] Antithrombotic drugs can be divided into anticoagulant drugs, antiplatelet aggregation drugs, and thrombolytic drugs. Clinically, antiplatelet drugs such as aspirin and clopidogrel are mainly used for prevention and treatment of thromboembolic diseases, and prevention is the...

Claims

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Application Information

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IPC IPC(8): A61K36/736A23L33/00A23L33/105A61P7/02A61P9/10A61K131/00
CPCA61K36/736A61P7/02A61P9/10A23L33/00A23L33/105A61K2236/37A23V2002/00A23V2200/326A61K36/00A23L2/04A23L21/12A23L19/00C12G3/04
Inventor 温轶韩铨张正方胡柳
Owner NATURAL MEDICINE INST OF ZHEJIANG YANGSHENGTANG
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