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Method for producing n-acetyl dipeptide and n-acetyl amino acid

A technology for acetyl dipeptide and amino acid, applied in the field of preparing N-acetyl dipeptide and N-acetyl amino acid, can solve the problems of long manufacturing time, rising manufacturing cost, difficulty in dipeptide mixture and the like

Pending Publication Date: 2021-06-01
CJ CHEILJEDANG CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The above-mentioned conventional method has the problems of high production cost and long production time due to the use of an expensive coupling agent and a multi-step reaction, and as a production method using dipeptide or N-acetic acid amino acid as a main substance, it has a great influence on the production of Dipeptide mixtures with various composition ratios have difficulty

Method used

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  • Method for producing n-acetyl dipeptide and n-acetyl amino acid
  • Method for producing n-acetyl dipeptide and n-acetyl amino acid
  • Method for producing n-acetyl dipeptide and n-acetyl amino acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1. Selectivity of N-acetylmethionine dipeptide (NALM-Met) according to catalyst type

[0052] In order to compare the selectivity of N-acetylmethionine dipeptide (hereinafter referred to as 'NALM-Met') and N-acetylmethionine (hereinafter referred to as 'NALM') according to the type of catalyst, methionine (0.67 mol), acetic anhydride (0.70 moles), and acetic acid (1.83 moles), to which 0.025 moles of one of the following items: calcium hydroxide (Ca(OH) 2 ), calcium chloride (CaCl 2 ), basic copper carbonate (Cu(OH) 2 CO 3 ), copper sulfate (CuSO 4 ), ammonium chloride (NH 4 Cl), sodium acetate (CH 3 CO 2 Na), phosphoric acid (H 3 PO 4 ), and sodium chloride (NaCl), and stirred at room temperature for 4 hours. An experimental group to which no salt was added under the same conditions was used as a control group. After confirming by using thin layer chromatography (thin layer chromatography; TLC), when the reaction is finished, a sample is taken and the...

Embodiment 2

[0058] Example 2. According to Ca(OH) 2 Selectivity of the amount of NALM-Met used

[0059] In order to compare the Ca(OH) 2 The selectivity of the amount of use is to mix methionine (0.67 mol), acetic anhydride (0.70 mol), and acetic acid (1.83 mol) and add 0%, 2.5%, 3.75%, 5%, and 10% to the methionine mole. , 20%, or 40% Ca(OH) 2 , and stirred at room temperature for 4 hours. Use does not use Ca(OH) 2 The experimental group served as the control group. After confirming by using thin-layer chromatography, take a sample when the reaction ends and perform high-performance liquid chromatography to confirm the concentration after the sample is diluted to 500 times, then, calculate the selectivity according to the calculation formula 1, and the results are shown in Table 2 middle.

[0060] [Table 2]

[0061]

[0062] According to the experimental results, it was confirmed that after adding Ca(OH) 2 The NALM-Met selectivity relative to the control group was improved in ...

Embodiment 3

[0063] Example 3. Selectivity of NALM-Met according to the amount of acetic acid used

[0064] In order to compare the selectivity of N-acetylmethionine dipeptide according to the amount of acetic acid used as solvent, methionine (0.67 mol), acetic anhydride (0.70 mol), and Ca(OH) 2 (0.025 moles), and with respect to the mass of methionine 0.1 times, 0.5 times, 1.0 times, 3.0 times, 5.0 times, or 10.0 times the quality of acetic acid and stirred at room temperature for 4 hours. After confirming by using thin layer chromatography, take a sample when the reaction ends and carry out high performance liquid chromatography to confirm the concentration after the sample is diluted to 500 times, then, calculate the selectivity according to the calculation formula 1, and the results are shown in the table 3 and figure 1 middle.

[0065] [table 3]

[0066]

[0067] According to the experimental results, there is a significant exponential function relationship between the amount of ...

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Abstract

The present invention provides a method for producing an N-acetyl dipeptide and an N-acetyl amino acid, comprising the step of reacting an amino acid with acetic anhydride or acetyl chloride to form an N-acetyl dipeptide and an N-acetyl amino acid.

Description

technical field [0001] The present invention relates to methods for preparing N-acetyl dipeptides and N-acetyl amino acids. This result was researched with the financial resources of the Ministry of Agriculture, Forestry, Livestock and Food with the support of the Agricultural Life Industry Technology Development Project of the Agriculture, Forestry and Food Technology Planning and Evaluation Institute (Project No. 117030-3). Background technique [0002] A dipeptide in which two amino acids that are the same or different from each other are connected to each other by a peptide bond is one of substances used as a main raw material in various fields such as animal nutrition, pharmaceuticals, and cosmetics. Based on high bioavailability, dipeptides are used as antibody drugs in the pharmaceutical field, and as functional cosmetic raw materials based on cell activation and active oxygen inhibition functions. In the field of animal nutrition, amino acids and dipeptides are used...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K5/06C07K5/062C07K5/065
CPCC07K5/06026C07K5/06043C07K5/06052C07K5/0606C07K5/06069C07K5/06078C07K5/06086C07K5/06095C07K5/06113C07K5/06104C07K5/06147C07K5/06156C07K5/06165C07K1/088C07C319/20C07C323/58C07K5/06C07K5/06191B01J23/02C07B2200/13C07C319/12C07C319/26C07K1/02C07K1/306
Inventor 李周映李昌锡全进祐文准玉朴陈承
Owner CJ CHEILJEDANG CORP
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