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A kind of nano ferric oxide/bovine serum albumin composite material and its preparation method and application

A technology of bovine serum albumin and iron ferric oxide, which is applied in the field of nanomaterials, can solve the problems of easy sedimentation and easy aggregation of magnetic materials, and achieve the effects of promoting adhesion, strong biocompatibility, and improving toxicity

Active Publication Date: 2022-05-17
XIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the invention is to solve the problem of easy agglomeration and easy settlement of traditional magnetic materials in the prior art

Method used

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  • A kind of nano ferric oxide/bovine serum albumin composite material and its preparation method and application
  • A kind of nano ferric oxide/bovine serum albumin composite material and its preparation method and application
  • A kind of nano ferric oxide/bovine serum albumin composite material and its preparation method and application

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preparation example Construction

[0065] In a specific embodiment of the present invention, the preparation method of the nanometer iron ferric oxide / bovine serum albumin composite material comprises the following steps:

[0066] (1) hybridizing the mixture of bovine serum albumin and multi-walled carbon nanotubes under ice bath or freezing conditions, and then freeze-drying to obtain a hybrid complex of multi-walled carbon nanotubes and bovine serum albumin;

[0067] (2) The organic solvent containing the first oxidant is mixed with ferric chloride, then the second oxidant is added and mixed;

[0068] (3) Mix the products obtained in step (1) and step (2), and react at 200-500°C to obtain nanotetroxide with the multi-walled carbon nanotube and bovine serum albumin hybrid complex as a template Three iron particles;

[0069] (4) The multi-walled carbon nanotubes and bovine serum albumin hybrid complexes obtained in step (3) are treated with salt solution to obtain the multi-walled carbon nanotubes and bovine s...

Embodiment 1

[0114] Embodiment 1 A kind of nano ferric oxide / bovine serum albumin composite material

[0115] (1) 1g multi-walled carbon nanotubes are mixed with 10g bovine serum albumin in an aqueous solution, first in an ultrasonic cleaner, under ice bath conditions, ultrasonic power is 500W, frequency is 50kHz under the condition of ultrasonic 10 minutes; Then put 10.5 g of the mixed solution was placed in an ultrasonic cell pulverizer with a power of 200 W and a frequency of 50 kHz, ultrasonicated for 1 hour in an ice bath, then frozen with liquid nitrogen, and freeze-dried on a freeze dryer to obtain 9 g of multi-walled carbon nanotubes and bovine serum albumin hybrid complex powder.

[0116] (2) 10g of FeCl 3 ·6H 2 O was ground into a powder in an agate mortar, and 5g of sodium acetate powder was weighed, and 25g of ethylene glycol reagent was added to a dry beaker at the same time, and then 8g of ethylenediamine was added to it to disperse the powder, sealed with a parafilm, and p...

Embodiment 2

[0123] Embodiment 2 A kind of nano ferric oxide / bovine serum albumin composite material

[0124] (1) 1.5g multi-walled carbon nanotubes are mixed with 20g bovine serum albumin in an aqueous solution, first in an ultrasonic cleaning machine, under ice bath conditions, ultrasonic power is 500W, frequency is 50kHz under the condition of ultrasound for 10 minutes; then Place 21.5 g of the mixed solution in an ultrasonic cell pulverizer with a power of 200 W and a frequency of 50 kHz, sonicate for 1 hour in an ice bath, then freeze with liquid nitrogen, and freeze-dry on a freeze dryer to obtain 20 g of multi-walled carbon Hybrid composite powder of nanotubes and bovine serum albumin.

[0125] (2) 13g of FeCl 3 ·6H 2 O was ground into a powder in an agate mortar, and 7g of sodium acetate powder was weighed, and 28g of ethylene glycol reagent was added to a dry beaker at the same time, and then 10g of ethylenediamine was added to it to disperse the powder, sealed with a parafilm, ...

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Abstract

The invention provides a nano ferric oxide / bovine serum albumin composite material, a preparation method and an application. The nano ferroferric oxide / bovine serum albumin composite material provided by the present invention comprises multi-walled carbon nanotubes and bovine serum albumin hybrid complexes and nano ferric oxide, wherein the multi-walled carbon nanotubes and bovine serum albumin hybrid complexes The material wraps the nano ferric oxide. The nano ferric iron tetroxide / bovine serum albumin composite material provided by the invention contains bovine serum albumin, which can effectively improve the toxicity of the nano ferric ferric oxide.

Description

technical field [0001] The invention belongs to the field of nanometer materials, and relates to a nanometer ferric oxide / bovine serum albumin composite material and a preparation method thereof. Background technique [0002] The bovine serum albumin (BSA) molecule has 583 amino acid residues, the molecular weight is 66.430kDa, and the isoelectric point is about 4.7. BSA is generally used as a stabilizer in the preservation solution and reaction solution of restriction enzymes or modified enzymes, because some enzymes are unstable or have low activity at low concentrations. After adding BSA, it may play the role of "protection" or "carrier", and the activity of many enzymes can be greatly improved after adding BSA. Magnetic nanoparticles are widely used in the fields of magnetic resonance medicine, radar technology, information storage, flexible electronics, sewage treatment, etc. By the attention. Therefore, the preparation technology of nano-magnetic particles and their...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L89/00C08K9/10C08K3/04C08K3/22B82Y40/00
CPCC08K9/10C08K3/041C08K3/22B82Y40/00C08K2201/011C08K2003/2275C08L89/00Y02E60/10
Inventor 周星李亚新郝亚亚何鑫玉方长青
Owner XIAN UNIV OF TECH
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