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Preparation method and application of a bioceramic scaffold with micro-nano structure on the surface of hollow microspheres

A technology of micro-nano structure and bioceramics, which is applied in the field of biomedical materials, can solve the problems of detachment of microspheres, the inability to realize the tight connection between microspheres and scaffolds, environmental pollution, etc., and achieve the effect of simplifying the synthesis conditions

Active Publication Date: 2022-06-03
HARBIN INST OF TECH AT WEIHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the one hand, the synthesis of hollow hydroxyapatite microspheres requires the use of organic solvents or mixed organic solvent reaction systems and the addition of surfactants or emulsifiers, which is costly and may cause pollution to the environment. In practical applications, residual Organic solvents may have an impact on the service effect
On the other hand, in terms of the stent-microsphere drug-loaded controlled release system, the microspheres are loaded onto the surface of the stent by soaking and coating the microsphere solution, which cannot realize the tight connection between the microspheres and the stent, and easily leads to the detachment of the microspheres.

Method used

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  • Preparation method and application of a bioceramic scaffold with micro-nano structure on the surface of hollow microspheres
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  • Preparation method and application of a bioceramic scaffold with micro-nano structure on the surface of hollow microspheres

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Embodiment 1

[0029] The invention provides a preparation method of a bioceramic scaffold with a micro-nano structure on the surface of a hollow microsphere, which comprises the following steps:

[0030] (1) Preparation of 3D printing bioceramic scaffold printing paste:

[0031] According to the parts by weight, weigh 1 part of sodium alginate, 0.5 part of polyvinyl alcohol, and 100 parts of distilled water, first dissolve the polyvinyl alcohol in distilled water, then add sodium alginate, stir and mix evenly to obtain a premix; The calcium powder and the premix are uniformly mixed according to the proportion of the final solid phase content of 58wt% to prepare the ceramic printing paste.

[0032] (2) Preparation of 3D printed bioceramic scaffold model:

[0033] The ceramic printing slurry prepared in step (1) is loaded into the barrel of the 3D printer, and the model to be printed is imported into the 3D printer software for printing. The diameter of the nozzle used in the printer is 0.5m...

Embodiment 2

[0039]The invention provides a preparation method of a bioceramic scaffold with a micro-nano structure on the surface of a hollow microsphere, which comprises the following steps:

[0040] (1) Preparation of 3D printing bioceramic scaffold printing paste:

[0041] According to the parts by weight, weigh 2 parts of sodium alginate, 3 parts of polyvinyl alcohol, and 100 parts of distilled water, first dissolve the polyvinyl alcohol in distilled water, then add sodium alginate, stir and mix evenly to obtain a premix; The ceramic printing paste prepared by mixing calcium and calcium silicate powder and premix liquid uniformly according to the final solid phase content of 45wt%.

[0042] (2) Preparation of 3D printed bioceramic scaffold model:

[0043] The ceramic printing slurry prepared in step (1) is loaded into the barrel of the 3D printer, and the model to be printed is imported into the 3D printer software for printing. The diameter of the nozzle used by the printer is 0.4mm...

Embodiment 3

[0049] The invention provides a preparation method of a bioceramic scaffold with a micro-nano structure on the surface of a hollow microsphere, which comprises the following steps:

[0050] (1) Preparation of 3D printing bioceramic scaffold printing paste:

[0051] According to the parts by weight, weigh 3 parts of sodium alginate, 3 parts of polyvinyl alcohol, and 100 parts of distilled water, first dissolve the polyvinyl alcohol in distilled water, then add sodium alginate, stir and mix evenly to obtain a premix; The calcium acid powder and the premix are uniformly mixed according to the proportion of the final solid phase content of 40wt% to prepare the ceramic printing paste.

[0052] (2) Preparation of 3D printed bioceramic scaffold model:

[0053] The ceramic printing slurry prepared in step (1) is loaded into the barrel of the 3D printer, and the model to be printed is imported into the 3D printer software for printing. The diameter of the nozzle used by the printer is...

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Abstract

The present invention provides a preparation method and application of a bioceramic scaffold with micro-nano structure on the surface of hollow microspheres, which solves the problem of how to realize the synergistic effect of drug-loaded microspheres and bone repair scaffolds in the prior art to obtain a scaffold-microsphere drug controlled release system The technical problem is to put the 3D printed bioceramic support and hexametaphosphate solution into the hydrothermal reaction kettle for hydrothermal reaction. After the hydrothermal reaction is completed, a bioceramic support with a micro-nano structure on the surface of hollow microspheres is obtained. The present invention also Disclosed is the application of a bioceramic support with a micro-nano structure on the surface of hollow microspheres, which can be widely used in the technical field of biomedical materials.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a preparation method and application of a bioceramic scaffold with a micro-nano structure on the surface of a hollow microsphere. Background technique [0002] It is well known that the surface of bone repair scaffolds is in direct contact with cells, and the surface properties of bone repair scaffolds, such as micro-nano structure, hardness, hydrophobicity, and surface potential, can affect stem cell differentiation, surface protein adsorption, pre-inflammatory response, cytoskeleton and The regulation of focal adhesion formation and other aspects is an important way to improve the ability of promoting osteogenesis and angiogenesis to study the surface micro-nano structure of bioactive ceramic scaffolds. To achieve the regeneration of functionalized tissues, not only the supply of sufficient growth factors and nutrients in the scaffolds, but also specific functional...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C04B38/06C04B35/447C04B35/622B33Y10/00B33Y70/10
CPCC04B38/067C04B35/447C04B35/622B33Y70/10B33Y10/00C04B2235/6026C04B2235/656C04B2235/6562C04B2235/6567C04B38/0645C04B38/0025
Inventor 张鹏刘康孙金平王传杰陈刚
Owner HARBIN INST OF TECH AT WEIHAI
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