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Abelmoschus manihot flower flavonoid effective part as well as preparation method and application thereof

A technology of flavonoids and effective parts of hollyhocks, which is applied in the field of medicine, can solve the problems of large variation of active ingredient content, low extraction and transfer rate, lack of practical research, etc., and achieves good prevention or treatment of sunscreen, simple process, and good anti-aging effect. Effect

Active Publication Date: 2021-06-01
JIANGSU SUZHONG PHARM GRP CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the composition of hollyhock flower extract is complex, and the content of active ingredients varies greatly. Different content compositions usually have a greater impact on its pharmacological effects. However, the actual research on the use of hollyhock flower extract in cosmetics is relatively scarce, and its extraction transfer rate Low, high extraction energy consumption, large amount of solvent

Method used

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  • Abelmoschus manihot flower flavonoid effective part as well as preparation method and application thereof
  • Abelmoschus manihot flower flavonoid effective part as well as preparation method and application thereof
  • Abelmoschus manihot flower flavonoid effective part as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1 Preparation of effective fractions of flavonoids from hollyhock flower

[0042] Grind 100g of hollyhock flowers into coarse powder, extract with 15 times of 60% ethanol under reflux, and obtain the ambrette extract; after the amber extract is absorbed by activated carbon, filter it with an ultrafiltration membrane with a molecular weight cut-off of 3500, and collect the filtrate , the filtrate is filtered with an ultrafiltration membrane with a molecular weight cut-off of 500 to obtain a concentrated solution, and the concentrated solution is decompressed to recover ethanol at 50 ° C, and then treated with D101 macroporous resin. The treatment process of the macroporous resin is as follows: : The diameter-to-height ratio of the macroporous resin is 1:6, the concentration of the sample solution (aqueous solution) is 0.15g crude drug / ml, the volume of the sample solution is 7BV, and the sample is loaded at a flow rate of 2BV / h, with 6BV of pure water and 3BV of 5...

Embodiment 2

[0043] Example 2 Preparation of effective fractions of flavonoids from hollyhock flower

[0044] Grind 100g of hollyhock flowers into coarse powder, extract with 18 times of 70% ethanol under reflux, and obtain the ambrette extract; filter the amber extract with an ultrafiltration membrane with a molecular weight cut-off of 3500, collect the filtrate, Use an ultrafiltration membrane with a molecular weight cut-off of 1000 to filter out 70% of the liquid to obtain a concentrated solution. After the concentrated solution is decompressed at 60°C to recover ethanol, it is treated with D101 macroporous resin. The treatment process of the macroporous resin is: macroporous resin diameter The height ratio is 1:5, the concentration of the sample solution is 0.15g crude drug / ml, the volume of the sample solution is 6BV, the sample is loaded at a flow rate of 2BV / h, and impurities are removed with 6BV of pure water and 3BV of 5% ethanol at a flow rate of 2BV / h. Elute with 4BV 60% ethanol...

Embodiment 3

[0045] Example 3 Preparation of effective fractions of flavonoids from hollyhock flower

[0046] Grind 100g of hollyhock flowers into coarse powder, extract by percolation with 18 times of 60% ethanol to obtain the ambrette extract; The concentrated solution is obtained by filtering out 80% of the liquid with an ultrafiltration membrane with a molecular weight cut-off of 500. After the concentrated solution is decompressed at 60°C to recover ethanol, it is treated with D101 macroporous resin. The treatment process of the macroporous resin is: macroporous resin The diameter-to-height ratio is 1:8, the concentration of the sample solution is 0.15g crude drug / ml, the volume of the sample solution is 8BV, the sample is loaded at a flow rate of 2BV / h, and impurities are removed with 6BV of pure water and 3BV of 5% ethanol at a flow rate of 2BV / h , 4BV 60% ethanol was used to elute with a flow rate of 3BV / h to obtain an eluate, and the eluate was recovered under reduced pressure at ...

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Abstract

The invention relates to an abelmoschus manihot flower flavonoid effective part and a preparation method and an application thereof, and belongs to the field of medicine, the abelmoschus manihot flower flavonoid effective part comprises the following flavonoid components: quercetin, and quercetin-3'-O-glucoside, myricetin, gossypoin-8-O-beta-D-glucuronide, isoquercitrin, rutin and hyperoside, the mass ratio of the above components is 1:13-33:1-7:14-38:12-32:1-5:18-42,and the abelmoschus manihot flower flavonoid effective part has good effects of preventing or treating skin aging, repairing and resisting aging.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an effective part of flavonoids from hollyhock flower and its preparation method and application, in particular to a high-purity effective part of flavonoid from hollyhock flower prepared by a membrane separation coupling resin method and its application. Background technique [0002] Hollyhock flower is the dried corolla of Malvaceae plant Abelmoschus manihot (L.) Medic. It tastes sweet and cold, and returns to the kidney and bladder channels; scald. The drug was first recorded in "Jiayou Materia Medica", and the 2010 edition of "Chinese Pharmacopoeia" included this drug. "Jiayou Materia Medica" records: hollyhock flower is used as the last application for those who have persistent sores and pus for a long time. "Compendium of Materia Medica" says: hollyhock flower, its flower smell is sweet, cold, slippery, and non-toxic. It can be used as an essential medicine for sores t...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P17/18A61P17/00A61K8/9789A61Q17/04A61Q19/00A61Q19/08A61K133/00
CPCA61K36/185A61P17/18A61P17/00A61K8/9789A61Q17/04A61Q19/004A61Q19/08A61K2236/333A61K2236/53A61K2236/55A61K2800/805Y02A50/30
Inventor 唐海涛王丹丹葛海涛王殿广彭小兰杨冰
Owner JIANGSU SUZHONG PHARM GRP CO LTD
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