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Surface modification method of macroporous polystyrene resin for blood purification and blood purifier

A polystyrene resin and blood purification technology, which is applied in chemical instruments and methods, suction instruments, medicine instruments, etc. The effect of high efficiency and easy mass industrial production

Active Publication Date: 2021-05-25
珠海健科医用材料有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The radiation grafting method avoids the shortcomings of many homopolymers and low grafting efficiency in the chemical grafting method

Method used

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  • Surface modification method of macroporous polystyrene resin for blood purification and blood purifier
  • Surface modification method of macroporous polystyrene resin for blood purification and blood purifier
  • Surface modification method of macroporous polystyrene resin for blood purification and blood purifier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Put 50g of polystyrene macroporous adsorption resin in a plastic bag or a glass container, and leave a certain volume of space on the top of the resin to retain enough oxygen. The resin was irradiated under γ-rays with a dose of 10 kGy. The irradiated resin now forms a large number of peroxides on the surface, and the peroxides can be used as free radical initiators to initiate the polymerization and grafting reactions of monomers.

[0032] In 15 mL of isopropanol, take 1.0 g of the above-mentioned polystyrene resin and 0.5 g of hydroxyethyl methacrylate (HEMA), put them into a three-necked flask, and under the protection of nitrogen, adjust the temperature of the water bath to 80 ° C, and react for 4 h under stirring. After rinsing with a large amount of ethanol, it is dried to obtain a HEMA-grafted polystyrene macroporous adsorption resin.

[0033] from figure 1 It can be seen that the resin after HEMA grafting is at 1725cm －1 The C=O stretching vibration peak appe...

Embodiment 2

[0035] In 15 mL of isopropanol, take 1.0 g of the irradiated polystyrene resin and 0.1 g of HEMA in Example 1, put them into a three-necked flask, and under the protection of nitrogen, adjust the temperature of the water bath to 80 ° C, and react for 4 h under stirring. After rinsing with a large amount of ethanol, it is dried to obtain a HEMA-grafted polystyrene macroporous adsorption resin.

Embodiment 3

[0037] In 15 mL of water, take 1.0 g of the irradiated polystyrene resin and 0.5 g of HEMA in Example 1, put them into a three-necked flask, and under the protection of nitrogen, adjust the temperature of the water bath to 80°C and react for 6 h under stirring. After washing, dry to obtain HEMA-grafted polystyrene macroporous adsorption resin.

[0038] The adsorption properties of the HEMA-grafted polystyrene macroporous adsorption resins obtained in Examples 1 to 3 are shown in Table 1 below.

[0039] The BET adsorption performance of the HEMA grafted resin of table 1 embodiment 1 to 3

[0040]

[0041] From the data in Table 1, it can be seen that the specific surface area of ​​the resin generally decreases with the increase of the grafting amount, the average pore volume gradually decreases, and the average pore diameter fluctuates slightly. Due to the small amount of grafting, the specific surface area and average pore volume change range is small, which will not serio...

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Abstract

The invention relates to a surface modification method of macroporous polystyrene resin for blood purification and a blood purifier. The surface modification method comprises the following steps: irradiating the macroporous polystyrene resin, and placing the irradiated macroporous polystyrene resin in a solution containing a modifying monomer for grafting reaction, with the modifying monomer containing a hydrophilic group. The large-aperture polystyrene adsorption resin for blood purification has better anticoagulant property and blood compatibility, and the modification method is simple and environment-friendly.

Description

technical field [0001] The invention relates to the technical field of medical polymer materials, in particular to a method for modifying the surface of a macroporous polystyrene resin for blood purification and a blood purifier. Background technique [0002] The polystyrene adsorbent resin ball itself does not have blood compatibility and anticoagulant properties. When used in the field of blood purification therapy, surface modification is required to make the resin have blood compatibility and anticoagulant properties to meet the requirements of clinical use. Among them The surface chemical grafting method is a commonly used surface modification method, and its principle is to graft blood-compatible polymers on the surface of polystyrene microspheres. [0003] The currently used surface grafting method is mainly the chemical grafting method. In this method, polystyrene microspheres are dispersed in a solution containing grafted monomers, and free radical polymerization is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/40B01J20/26B01J20/30A61M1/16C08L25/06
CPCC08J9/405B01J20/265A61M1/1621A61M2207/00C08J2325/06
Inventor 董凡史作森毕大武崔占臣
Owner 珠海健科医用材料有限公司
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